{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T01:12:59Z","timestamp":1768093979557,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,9,20]],"date-time":"2013-09-20T00:00:00Z","timestamp":1379635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004410","name":"European Molecular Biology Organization","doi-asserted-by":"publisher","award":["ASTF 332\u20102208"],"award-info":[{"award-number":["ASTF 332\u20102208"]}],"id":[{"id":"10.13039\/100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p>\n                    Memo is a widely expressed 33\u2010kDa protein required for heregulin (HRG)\u2010, epidermal growth factor (EGF)\u2010, and fibroblast growth factor (FGF)\u2010induced cell motility. Studies in mouse embryonic fibroblasts, wild\u2010type or knockout for Memo, were performed to further investigate the role of Memo downstream of FGFR. We demonstrated that Memo associates with the FGFR signalosome and is necessary for optimal activation of signaling. To uncover Memo's physiological role, Memo conditional\u2010knockout mice were generated. These animals showed a reduced life span, increased insulin sensitivity, small stature, graying hair, alopecia, kyphosis, loss of subcutaneous fat, and loss of spermatozoa in the epididymis. Memo\u2010knockout mice also have elevated serum levels of active vitamin D, 1,25\u2010dihydroxyvitamin D\n                    <jats:sub>3<\/jats:sub>\n                    (1,25(OH)\n                    <jats:sub>2<\/jats:sub>\n                    D), and calcium compared to control littermates expressing Memo. In summary, the results from\n                    <jats:italic>in vivo<\/jats:italic>\n                    and\n                    <jats:italic>in vitro<\/jats:italic>\n                    models support the hypothesis that Memo is a novel regulator of FGFR signaling with a role in controlling 1,25(OH)\n                    <jats:sub>2<\/jats:sub>\n                    D production and normal calcium homeostasis.\u2014Haenzi, B., Bonny, O., Masson, R., Lienhard, S., Dey, J. H., Kuro\u2010o, M., Hynes, N. E. Loss of Memo, a novel FGFR regulator, results in reduced lifespan.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    28, 327\u2013336 (2014).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.13-228320","type":"journal-article","created":{"date-parts":[[2013,9,21]],"date-time":"2013-09-21T02:32:42Z","timestamp":1379730762000},"page":"327-336","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Loss of Memo, a novel FGFR regulator, results in reduced lifespan"],"prefix":"10.1096","volume":"28","author":[{"given":"Barbara","family":"Haenzi","sequence":"first","affiliation":[{"name":"Friedrich Miescher Institute for Biomedical Research Basel Switzerland"},{"name":"University of Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Bonny","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology University of Lausanne Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00e9gis","family":"Masson","sequence":"additional","affiliation":[{"name":"Friedrich Miescher Institute for Biomedical Research Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Lienhard","sequence":"additional","affiliation":[{"name":"Friedrich Miescher Institute for Biomedical Research Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien H.","family":"Dey","sequence":"additional","affiliation":[{"name":"Friedrich Miescher Institute for Biomedical Research Basel Switzerland"},{"name":"University of Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Kuro\u2010o","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Texas Southwestern Medical Center Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy E.","family":"Hynes","sequence":"additional","affiliation":[{"name":"Friedrich Miescher Institute for Biomedical Research Basel Switzerland"},{"name":"University of Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,9,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1134"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.032094"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2005.01.001"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2005.01.008"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C500457200"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05315"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/36285"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2004.09.007"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200419081"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2010.02.008"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.20118"},{"key":"e_1_2_7_13_1","first-page":"1399","article-title":"Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor","volume":"52","author":"Aslakson C. 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