{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:05:49Z","timestamp":1791489949110,"version":"4.3.4"},"reference-count":68,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,5,30]],"date-time":"2013-05-30T00:00:00Z","timestamp":1369872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R01 ES015056"],"award-info":[{"award-number":["R01 ES015056"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["U01 ES015674"],"award-info":[{"award-number":["U01 ES015674"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:p>\n                    Allergic contact dermatitis is a common skin disease associated with inflammation and persistent pruritus. Transient receptor potential (TRP) ion channels in skin\u2010innervating sensory neurons mediate acute inflammatory and pruritic responses following exogenous stimulation and may contribute to allergic responses. Genetic ablation or pharmacological inhibition of TRPA1, but not TRPV1, inhibited skin edema, keratinocyte hyperplasia, nerve growth, leukocyte infiltration, and antihistamine\u2010resistant scratching behavior in mice exposed to the haptens, oxazolone and urushiol, the contact allergen of poison ivy. Hapten\u2010challenged skin of TRPA1\u2010deficient mice contained diminished levels of inflammatory cytokines, nerve growth factor, and endogenous pruritogens, such as substance P (SP) and serotonin. TRPA1\u2010deficient sensory neurons were defective in SP signaling, and SP\u2010induced scratching behavior was abolished in\n                    <jats:italic>Trpa1<\/jats:italic>\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    mice. SP receptor antagonists, such as aprepitant inhibited both hapten\u2010induced cutaneous inflammation and scratching behavior. These findings support a central role for TRPA1 and SP in the integration of immune and neuronal mechanisms leading to chronic inflammatory responses and pruritus associated with contact dermatitis.\u2014Liu, B., Escalera, J., Balakrishna, S., Fan, L., Caceres, A. I., Robinson, E., Sui, A., McKay, M. C., McAlexander, M. A., Herrick, C. A., Jordt, S. E., TRPA1 controls inflammation and pruritogen responses in allergic contact dermatitis. FASEB J. 27, 3549\u20133563 (2013).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.13-229948","type":"journal-article","created":{"date-parts":[[2013,5,31]],"date-time":"2013-05-31T02:02:54Z","timestamp":1369965774000},"page":"3549-3563","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":212,"title":["TRPA1 controls inflammation and pruritogen responses in allergic contact dermatitis"],"prefix":"10.1096","volume":"27","author":[{"given":"Boyi","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Pharmacology Yale School of Medicine New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmine","family":"Escalera","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Yale School of Medicine New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shrilatha","family":"Balakrishna","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Yale School of Medicine New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Yale School of Medicine New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana I.","family":"Caceres","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Yale School of Medicine New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eve","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of Dermatology Yale School of Medicine New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiwei","family":"Sui","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Yale School of Medicine New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Craig","family":"McKay","sequence":"additional","affiliation":[{"name":"Biological Reagents and Assay Development GlaxoSmithKline Pharmaceuticals Research Triangle Park North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Allen","family":"McAlexander","sequence":"additional","affiliation":[{"name":"Respiratory Therapy Area GlaxoSmithKline Pharmaceuticals King of Prussia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina A.","family":"Herrick","sequence":"additional","affiliation":[{"name":"Department of Dermatology Yale School of Medicine New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven E.","family":"Jordt","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Yale School of Medicine New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,5,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2000.106484"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1580\/PR31-05.1"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1011040"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2010.01995.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4643-06.2007"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02282"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-117812"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.02.023"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2789"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12264-012-1207-9"},{"key":"e_1_2_8_12_1","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1096\/fj.12-221218","article-title":"Superoxide generation and leukocyte accumulation: key elements in the mediation of leukotriene B4\u2010induced itch by transient receptor potential ankyrin 1 and transient receptor potential vanilloid 1","volume":"27","author":"Fernandes E. S.","year":"2012","journal-title":"FASEB J."},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00026.2005"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(92)90199-U"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02263498"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2004.01786.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2005.08.012"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.87"},{"key":"e_1_2_8_19_1","first-page":"8","article-title":"TRPV1 antagonist can suppress the atopic dermatitis\u2010like symptoms by accelerating skin barrier recovery","volume":"62","author":"Yun J. W.","year":"2011","journal-title":"J. Dermatol. Sci."},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2012.08.012"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11-188383"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5701011"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0888-7543(02)00013-7"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.12.6783"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.10050FP"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004410000202"},{"key":"e_1_2_8_27_1","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1111\/j.1600-0625.2011.01367.x","article-title":"Mouse models of acute, chemical itch and pain in humans","volume":"20","author":"La Motte R. H.","year":"2011","journal-title":"Exp. Dermatol."},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(94)00780-B"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05417.x"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0705923104"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.120462"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.103.049239"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0707216"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.01585.x"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.1999.tb00346.x"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700810"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2011.02.009"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(96)00619-1"},{"key":"e_1_2_8_39_1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0304-3940(99)00719-3","article-title":"Localization of the neurokinin 1 receptor on a subset of substance P\u2010positive and isolectin B4\u2010negative dorsal root ganglion neurons of the rat","volume":"274","author":"Banchet G. S.","year":"1999","journal-title":"Neurosci. Lett."},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1998.00140.x"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-3-42"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2008.08.037"},{"key":"e_1_2_8_43_1","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/0008-8749(82)90122-8","article-title":"A murine model system for contact sensitization to poison oak or ivy urushiol components","volume":"68","author":"Dunn I. S.","year":"1982","journal-title":"Cell. Immunol."},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1711.2005.01310.x"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.284"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118899"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0900591106"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/363159a0"},{"key":"e_1_2_8_49_1","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1016\/S0022-3565(24)37703-1","article-title":"Substance P induction of itch\u2010associated response mediated by cutaneous NK1 tachykinin receptors in mice","volume":"286","author":"Andoh T.","year":"1998","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(01)01588-6"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.2.1285"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1080\/08923970601067136"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1992.tb16592.x"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0706547"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc0906670"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010968"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1003937"},{"key":"e_1_2_8_58_1","first-page":"487","article-title":"More on aprepitant for erlotinib\u2010induced pruritus","volume":"364","author":"Mir O.","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e32834a41c2"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.58"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00158-2"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201208-1358OC"},{"key":"e_1_2_8_63_1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.2340\/0001555561245250","article-title":"Studies on pruritogenic and histamine\u2010releasing effects of some putative peptide neurotransmitters","volume":"61","author":"Fjellner B.","year":"1981","journal-title":"Acta Derm. Venereol."},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1159\/000211138"},{"key":"e_1_2_8_65_1","first-page":"1146","article-title":"Endothelin\u20101 causes pruritus in mice","volume":"231","author":"Trentin P. G.","year":"2006","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0905605106"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-2079rev"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0288"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11047"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.13-229948","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1096\/fj.13-229948","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.13-229948","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T17:46:22Z","timestamp":1761673582000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.13-229948"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,30]]},"references-count":68,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["10.1096\/fj.13-229948"],"URL":"https:\/\/doi.org\/10.1096\/fj.13-229948","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,30]]},"assertion":[{"value":"2013-02-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-05-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-05-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}