{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:07:18Z","timestamp":1791216438967,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,6,3]],"date-time":"2013-06-03T00:00:00Z","timestamp":1370217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK\u201070333"],"award-info":[{"award-number":["DK\u201070333"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK\u2010084646"],"award-info":[{"award-number":["DK\u2010084646"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["200948"],"award-info":[{"award-number":["200948"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:p>\n                    Cachexia is a wasting condition defined by skeletal muscle atrophy in the setting of systemic inflammation. To explore the site at which inflammatory mediators act to produce atrophy\n                    <jats:italic>in vivo<\/jats:italic>\n                    , we utilized mice with a conditional deletion of the inflammatory adaptor protein myeloid differentiation factor 88 (MyD88). Although whole\u2010body MyD88\u2010knockout (wbMyD88KO) mice resist skeletal muscle atrophy in response to LPS, muscle\u2010specific deletion of MyD88 is not protective. Furthermore, selective reexpression of MyD88 in the muscle of wbMyD88KO mice\n                    <jats:italic>via<\/jats:italic>\n                    electroporation fails to restore atrophy gene induction by LPS. To evaluate the role of glucocorticoids as the inflammation\u2010induced mediator of atrophy\n                    <jats:italic>in vivo<\/jats:italic>\n                    , we generated mice with targeted deletion of the glucocorticoid receptor in muscle (mGRKO mice). Muscle\u2010specific deletion of the glucocorticoid receptor affords a 71% protection against LPS\u2010induced atrophy compared to control animals. Furthermore, mGRKO mice exhibit 77% less skeletal muscle atrophy than control animals in response to tumor growth. These data demonstrate that glucocorticoids are a major determinant of inflammation\u2010induced atrophy\n                    <jats:italic>in vivo<\/jats:italic>\n                    and play a critical role in the pathogenesis of endotoxemic and cancer cachexia.\u2014Braun, T. P., Grossberg, A. J., Krasnow, S. M., Levasseur, P. R., Szumowski, M., Zhu, X. X., Maxson, J. E., Knoll, J. G., Barnes, A. P., and Marks, D. L., Cancer\u2010 and endotoxin\u2010induced cachexia require intact glucocorticoid signaling in skeletal muscle. FASEB J. 27, 3572\u20133582 (2013).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.13-230375","type":"journal-article","created":{"date-parts":[[2013,6,4]],"date-time":"2013-06-04T01:11:30Z","timestamp":1370308290000},"page":"3572-3582","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":103,"title":["Cancer\u2010 and endotoxin\u2010induced cachexia require intact glucocorticoid signaling in skeletal muscle"],"prefix":"10.1096","volume":"27","author":[{"given":"Theodore P.","family":"Braun","sequence":"first","affiliation":[{"name":"Pap\u00e9 Family Pediatric Research Institute Oregon Health and Science University Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron J.","family":"Grossberg","sequence":"additional","affiliation":[{"name":"Pap\u00e9 Family Pediatric Research Institute Oregon Health and Science University Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie M.","family":"Krasnow","sequence":"additional","affiliation":[{"name":"Pap\u00e9 Family Pediatric Research Institute Oregon Health and Science University Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter R.","family":"Levasseur","sequence":"additional","affiliation":[{"name":"Pap\u00e9 Family Pediatric Research Institute Oregon Health and Science University Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Szumowski","sequence":"additional","affiliation":[{"name":"Pap\u00e9 Family Pediatric Research Institute Oregon Health and Science University Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin Xia","family":"Zhu","sequence":"additional","affiliation":[{"name":"Pap\u00e9 Family Pediatric Research Institute Oregon Health and Science University Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia E.","family":"Maxson","sequence":"additional","affiliation":[{"name":"Knight Cancer Institute Oregon Health and Science University Portland Oregon USA"},{"name":"Division of Hematology and Medical Oncology Oregon Health and Science University Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Gabriel","family":"Knoll","sequence":"additional","affiliation":[{"name":"Pap\u00e9 Family Pediatric Research Institute Oregon Health and Science University Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony P.","family":"Barnes","sequence":"additional","affiliation":[{"name":"Pap\u00e9 Family Pediatric Research Institute Oregon Health and Science University Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel L.","family":"Marks","sequence":"additional","affiliation":[{"name":"Pap\u00e9 Family Pediatric Research Institute Oregon Health and Science University Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,6,3]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"3347","article-title":"Limited impact of total parenteral nutrition on nutritional status during treatment for small cell lung cancer","volume":"45","author":"Evans W. K.","year":"1985","journal-title":"Cancer Res."},{"key":"e_1_2_7_3_1","first-page":"251","article-title":"Weight loss and nutritional abnormalities in cancer patients: incidence, severity and significance","volume":"5","author":"De Wys W. D.","year":"1986","journal-title":"Clinics Oncol."},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-1525"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc927"},{"key":"e_1_2_7_6_1","first-page":"E996","article-title":"Activation of the ATP\u2010ubiquitin\u2010proteasome pathway in skeletal muscle of cachectic rats bearing a hepatoma","volume":"268","author":"Baracos V. E.","year":"1995","journal-title":"Am. J. Physiol. Endocrinol. Metab. Physiol."},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1065874"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.251541198"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00400-3"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200420174"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00626.2008"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.10-164152"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.09.027"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201006098"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117208"},{"key":"e_1_2_7_16_1","doi-asserted-by":"crossref","first-page":"R849","DOI":"10.1152\/ajpregu.1997.272.3.R849","article-title":"Intracellular regulation of protein degradation during sepsis is different in fast\u2010 and slow\u2010twitch muscle","volume":"272","author":"Tiao G.","year":"1997","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"e_1_2_7_17_1","first-page":"2290","article-title":"Experimental cancer cachexia induced by transplantable colon 26 adenocarcinoma in mice","volume":"50","author":"Tanaka Y.","year":"1990","journal-title":"Cancer Res."},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5247-08.2009"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20111020"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80086-2"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.01.001"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2006-0539"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.11.001"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2006-0465"},{"key":"e_1_2_7_25_1","first-page":"3059","article-title":"Endogenous glucocorticoids and impaired insulin signaling are both required to stimulate muscle wasting under pathophysiological conditions in mice","volume":"119","author":"Hu Z.","year":"2009","journal-title":"J. Clin. Invest."},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00512.2011"},{"key":"e_1_2_7_27_1","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1096\/fj.08-114249","article-title":"The I\u03baB kinases IKK\u03b1 and IKK\u03b2 are necessary and sufficient for skeletal muscle atrophy","volume":"23","author":"Van Gammeren D.","year":"2008","journal-title":"FASEB J."},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-2364com"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113466"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1155\/S0962935192000371"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1990.01410130044006"},{"key":"e_1_2_7_32_1","first-page":"245","article-title":"The distribution of lipopolysaccharide in normo\u2010complementemic and C3\u2010depleted rabbits and rhesus monkeys","volume":"101","author":"Mathison J. C.","year":"1980","journal-title":"Am. J. Pathol."},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118421"},{"key":"e_1_2_7_34_1","doi-asserted-by":"crossref","first-page":"E668","DOI":"10.1152\/ajpendo.1993.264.4.E668","article-title":"Glucocorticoids activate the ATP\u2010ubiquitin\u2010dependent proteolytic system in skeletal muscle during fasting","volume":"264","author":"Wing S. S.","year":"1993","journal-title":"Am. J. Physiol. Endocrionol. Metab."},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112344"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.9.3917"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(93)90036-N"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1207\/S15327914NC352_16"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3835(95)04026-9"},{"issue":"1","key":"e_1_2_7_40_1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1093\/humrep\/9.suppl_1.40","article-title":"Hepatic metabolism and distribution of mifepristone and its metabolites in rats","volume":"9","author":"Heikinheimo O.","year":"1994","journal-title":"Hum. Reprod."},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2990071"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(97)00010-3"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.13-230375","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1096\/fj.13-230375","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.13-230375","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T17:46:28Z","timestamp":1761673588000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.13-230375"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,3]]},"references-count":41,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["10.1096\/fj.13-230375"],"URL":"https:\/\/doi.org\/10.1096\/fj.13-230375","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,3]]},"assertion":[{"value":"2013-03-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-05-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-06-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}