{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:00:33Z","timestamp":1790935233621,"version":"4.1.0"},"reference-count":60,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,6,6]],"date-time":"2013-06-06T00:00:00Z","timestamp":1370476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:p>\n                    In osteoclasts, Src controls podosome organization and bone degradation, which leads to an osteopetrotic phenotype in\n                    <jats:italic>src<\/jats:italic>\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    mice. Since this phenotype was even more severe in\n                    <jats:italic>src<\/jats:italic>\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    hck\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    mice, we examined the individual contribution of Hck in bone homeostasis. Compared to\n                    <jats:italic>wt<\/jats:italic>\n                    mice,\n                    <jats:italic>hck<\/jats:italic>\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    mice exhibited an osteopetrotic phenotype characterized by an increased density of trabecular bone and decreased bone degradation, although osteoclastogenesis was not impaired. Podosome organization and matrix degradation were found to be defective in\n                    <jats:italic>hck<\/jats:italic>\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    osteoclast precursors (preosteoclast) but were normal in mature\n                    <jats:italic>hck<\/jats:italic>\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    osteoclasts, probably through compensation by Src, which was specifically overexpressed in mature osteoclasts. As a consequence of podosome defects, the 3\u2010dimensional migration of\n                    <jats:italic>hck<\/jats:italic>\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    preosteoclasts was strongly affected\n                    <jats:italic>in vitro. In vivo<\/jats:italic>\n                    , this translated by altered bone homing of preosteoclasts in\n                    <jats:italic>hck<\/jats:italic>\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    mice: in metatarsals of 1\u2010wk\u2010old mice, when bone formation strongly depends on the recruitment of these cells, reduced numbers of osteoclasts and abnormal developing trabecular bone were observed. This phenotype was still detectable in adults. In summmary, Hck is one of the very few effectors of preosteoclast recruitment described to date and thereby plays a critical role in bone remodeling.\u2014V\u00e9rollet, C., Gallois, A., Dacquin, R., Lastrucci, C., Pandruvada, S. M. N., Ortega, N., Poincloux, R., Behar, A., Cougoule, C., Lowell, C., Al Saati, T., Jurdic, P., Maridonneau\u2010Parini, I., Hck contributes to bone homeostasis by controlling the recruitment of osteoclast precursors. FASEB J. 27, 3608\u20133618 (2013).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.13-232736","type":"journal-article","created":{"date-parts":[[2013,6,7]],"date-time":"2013-06-07T00:42:43Z","timestamp":1370565763000},"page":"3608-3618","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Hck contributes to bone homeostasis by controlling the recruitment of osteoclast precursors"],"prefix":"10.1096","volume":"27","author":[{"given":"Christel","family":"V\u00e9rollet","sequence":"first","affiliation":[{"name":"Centre National de la Recherche Scientifique (CNRS) Unit\u00e9 Mixte de Recherche (UMR) 5089 Institut de Pharmacologie et de Biologie Structurale (IPBS) Toulouse France"},{"name":"Universit\u00e9 de Toulouse Toulouse France"},{"name":"Universit\u00e9 Paul Sabatier (UPS) Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Gallois","sequence":"additional","affiliation":[{"name":"New York University Langone Medical Center Cancer Institute New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Dacquin","sequence":"additional","affiliation":[{"name":"Institut de G\u00e9nomique Fonctionnelle de Lyon UMR 5242 Universit\u00e9 de Lyon 1 Lyon France"},{"name":"CNRS Ecole Normale Sup\u00e9rieure de Lyon Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Lastrucci","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique (CNRS) Unit\u00e9 Mixte de Recherche (UMR) 5089 Institut de Pharmacologie et de Biologie Structurale (IPBS) Toulouse France"},{"name":"Universit\u00e9 de Toulouse Toulouse France"},{"name":"Universit\u00e9 Paul Sabatier (UPS) Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subramanya N. 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