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We reported previously that the scaffolding protein RanBP9, which is overall increased in brains of patients with AD and in mutant APP transgenic mice, simultaneously promotes A\u03b2 generation and focal adhesion disruption by accelerating the endocytosis of APP and \u03b21\u2010integrin, respectively. Moreover, RanBP9 induces neurodegeneration\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    and mediates A\u03b2\u2010induced neurotoxicity. Here we show in primary hippocampal neurons that RanBP9 potentiates A\u03b2\u2010induced reactive oxygen species (ROS) overproduction, apoptosis, and calcium deregulation. Analyses of calcium\u2010handling measures demonstrate that RanBP9 selectively delays the clearance of cytosolic Ca\n                    <jats:sup>2+<\/jats:sup>\n                    mediated by the mitochondrial calcium uniporter through a process involving the translocation of cofilin into mitochondria and oxidative mechanisms. Further, RanBP9 retards the anterograde axonal transport of mitochondria in primary neurons and decreases synaptic mitochondrial activity in brain. These data indicate that RanBP9, cofilin, and A\u03b2 mimic and potentiate each other to produce mitochondrial dysfunction, ROS overproduction, and calcium deregulation, which leads to neurodegenerative changes reminiscent of those seen in AD.\u2014Roh. S.\u2010E., Woo, J. A., Lakshmana, M. K., Uhlar, C., Ankala, V., Boggess, T., Liu, T., Hong, Y.\u2010H., Mook\u2010Jung, I., Kim, S. J., Kang, D. E., Mitochondrial dysfunction and calcium deregulation by the RanBP9\u2010cofilin pathway. FASEB J. 27, 4776\u20134789 (2013).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.13-234765","type":"journal-article","created":{"date-parts":[[2013,8,27]],"date-time":"2013-08-27T20:22:55Z","timestamp":1377634975000},"page":"4776-4789","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Mitochondrial dysfunction and calcium deregulation by the RanBP9\u2010cofilin pathway"],"prefix":"10.1096","volume":"27","author":[{"given":"Seung\u2010Eon","family":"Roh","sequence":"first","affiliation":[{"name":"World Class University\u2013Neurocytomics Program Seoul National University College of Medicine Seoul Korea"},{"name":"Department of Physiology Seoul National University College of Medicine Seoul 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