{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T17:56:23Z","timestamp":1778954183706,"version":"3.51.4"},"reference-count":72,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,11,27]],"date-time":"2013-11-27T00:00:00Z","timestamp":1385510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008501","name":"East Carolina University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008501","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:p>\n                    Interstitial lung diseases (ILDs) are characterized by injury, inflammation, and scarring of alveoli, leading to impaired function. The etiology of idiopathic forms of ILD is not understood, making them particularly difficult to study due to the lack of appropriate animal models. Consequently, few effective therapies have emerged. We developed an inbred mouse model of ILD using vanadium pentoxide (V\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>5<\/jats:sub>\n                    ), the most common form of a transition metal found in cigarette smoke, fuel ash, mineral ores, and steel alloys. Pulmonary responses to V\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>5<\/jats:sub>\n                    , including dose\u2010dependent increases in lung permeability, inflammation, collagen content, and dysfunction, were significantly greater in DBA\/2J mice compared to C57BL\/6J mice. Inflammatory and fibrotic responses persisted for 4 mo in DBA\/2J mice, while limited responses in C57BL\/6J mice resolved. We investigated the genetic basis for differential responses through genetic mapping of V\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>5<\/jats:sub>\n                    \u2010induced lung collagen content in BXD recombinant inbred (RI) strains and identified significant linkage on chromosome 4 with candidate genes that associate with V\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>5<\/jats:sub>\n                    \u2010induced collagen content across the RI strains. Results suggest that V\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>5<\/jats:sub>\n                    may induce pulmonary fibrosis through mechanisms distinct from those in other models of pulmonary fibrosis. These findings should further advance our understanding of mechanisms involved in ILD and thereby aid in identification of new therapeutic targets.\u2014Walters, D. M., White, K. M., Patel, U., Davis, M. J., Veluci\u2010Marlow, R. M., Bhupanapadu Sunkesula, S. R., Bonner, J. C., Martin, J. R., Gladwell, W., Kleeberger, S. R. Genetic susceptibility to interstitial pulmonary fibrosis in mice induced by vanadium pentoxide (V\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>5<\/jats:sub>\n                    ).\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    28, 1098\u20131112 (2014).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.13-235044","type":"journal-article","created":{"date-parts":[[2013,11,28]],"date-time":"2013-11-28T00:08:58Z","timestamp":1385597338000},"page":"1098-1112","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Genetic susceptibility to interstitial pulmonary fibrosis in mice induced by vanadium pentoxide (V\n                    <sub>2<\/sub>\n                    O\n                    <sub>5<\/sub>\n                    )"],"prefix":"10.1096","volume":"28","author":[{"given":"Dianne M.","family":"Walters","sequence":"first","affiliation":[{"name":"Department of Physiology East Carolina University Greenville North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin M.","family":"White","sequence":"additional","affiliation":[{"name":"Department of Physiology East Carolina University Greenville North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ushma","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Physiology East Carolina University Greenville North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin J.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Physiology East Carolina University Greenville North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta M.","family":"Veluci\u2010Marlow","sequence":"additional","affiliation":[{"name":"Department of Physiology East Carolina University Greenville North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Solomon Raju Bhupanapadu","family":"Sunkesula","sequence":"additional","affiliation":[{"name":"Department of Physiology East Carolina University Greenville North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James C.","family":"Bonner","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences North Carolina State University Raleigh North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica R.","family":"Martin","sequence":"additional","affiliation":[{"name":"Laboratory of Respiratory Biology National Institute of Environmental Health Sciences, National Institutes of Health Research Triangle Park North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wes","family":"Gladwell","sequence":"additional","affiliation":[{"name":"Laboratory of Respiratory Biology National Institute of Environmental Health Sciences, National Institutes of Health Research Triangle Park North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven R.","family":"Kleeberger","sequence":"additional","affiliation":[{"name":"Laboratory of Respiratory Biology National Institute of Environmental Health Sciences, National Institutes of Health Research Triangle Park North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,11,27]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"99","volume-title":"Breathing in America","author":"Olsen A. 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