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We thus investigated the potential involvement of aldosterone in triggering a cardiac angiogenic response in the context of type\u20102 diabetes and the molecular pathways involved. Male 3\u2010wk\u2010old aldosterone synthase (AS)\u2010overexpressing mice and their control wild\u2010type (WT) littermates were fed a standard or high\u2010fat, high\u2010sucrose (HFHS) diet. After 6 mo of diet treatment, mice were euthanized, and cardiac samples were assayed by RT\u2010PCR, immunoblotting, and immunohistology. HFHS diet induced type\u20102 diabetes in WT (WT\u2010D) and AS (AS\u2010D) mice. VEGFa mRNAs decreased in WT\u2010D (\u201343%,\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.05\n                    <jats:italic>vs<\/jats:italic>\n                    . WT) and increased in AS\u2010D mice (+236%,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.01\n                    <jats:italic>vs<\/jats:italic>\n                    . WT\u2010D). In WT\u2010D mouse hearts, the proapoptotic p38MAPK was activated (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.05\n                    <jats:italic>vs<\/jats:italic>\n                    . WT and AS\u2010D), whereas Akt activity decreased (\u201364%,\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.05\n                    <jats:italic>vs<\/jats:italic>\n                    . WT). The AS mice, which exhibited a cardiac up\u2010regulation of IGF1\u2010R, showed an increase in Akt phosphorylation when diabetes was induced (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.05\n                    <jats:italic>vs<\/jats:italic>\n                    . WT and AS\u2010D). Contrary to WT\u2010D mice, AS\u2010D mouse hearts did not express inflammatory markers and exhibited a normal capillary density (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.05\n                    <jats:italic>vs<\/jats:italic>\n                    . WT\u2010D). To our knowledge, this is the first study providing new insights into the mechanisms whereby aldosterone prevents diabetes\u2010induced cardiac disorders.\u2014Fazal, L., Azibani, F., Bihry, N., Coutance, G., Polidano, E., Merval, R., Vodovar, N., Launay, J.\u2010M., Delcayre, C., Samuel, J.\u2010L. Akt\u2010mediated cardioprotective effects of aldosterone in type 2 diabetic mice.\n                    <jats:italic>FASEB J<\/jats:italic>\n                    . 28, 2430\u20132440 (2014).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.13-239822","type":"journal-article","created":{"date-parts":[[2014,2,20]],"date-time":"2014-02-20T21:44:05Z","timestamp":1392932645000},"page":"2430-2440","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Akt\u2010mediated cardioprotective effects of aldosterone in type 2 diabetic mice"],"prefix":"10.1096","volume":"28","author":[{"given":"Loubina","family":"Fazal","sequence":"first","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche en Sant\u00e9 (UMR\u2010S) 942 Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) Biochemistry Department Lariboisiere Hospital Paris France"},{"name":"Paris Diderot University Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feriel","family":"Azibani","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche en Sant\u00e9 (UMR\u2010S) 942 Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) Biochemistry Department Lariboisiere Hospital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Bihry","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche en Sant\u00e9 (UMR\u2010S) 942 Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) Biochemistry Department Lariboisiere Hospital Paris France"},{"name":"Assistance Publique\u2013H\u00f4pitaux de Paris (AP\u2010HP) Biochemistry Department Lariboisiere Hospital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Coutance","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche en Sant\u00e9 (UMR\u2010S) 942 Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) Biochemistry Department Lariboisiere Hospital Paris France"},{"name":"Paris Diderot University Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyne","family":"Polidano","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche en Sant\u00e9 (UMR\u2010S) 942 Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) Biochemistry Department Lariboisiere Hospital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9gine","family":"Merval","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche en Sant\u00e9 (UMR\u2010S) 942 Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) Biochemistry Department Lariboisiere Hospital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Vodovar","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche en Sant\u00e9 (UMR\u2010S) 942 Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) Biochemistry Department Lariboisiere Hospital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Marie","family":"Launay","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche en Sant\u00e9 (UMR\u2010S) 942 Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) Biochemistry Department Lariboisiere Hospital Paris France"},{"name":"Assistance Publique\u2013H\u00f4pitaux de Paris (AP\u2010HP) Biochemistry Department Lariboisiere Hospital Paris France"},{"name":"Paris Descartes University Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Delcayre","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche en Sant\u00e9 (UMR\u2010S) 942 Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) Biochemistry Department Lariboisiere Hospital Paris France"},{"name":"Paris Diderot University Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane\u2010Lise","family":"Samuel","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche en Sant\u00e9 (UMR\u2010S) 942 Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) Biochemistry Department Lariboisiere Hospital Paris France"},{"name":"Assistance Publique\u2013H\u00f4pitaux de Paris (AP\u2010HP) Biochemistry Department Lariboisiere Hospital Paris France"},{"name":"Paris Diderot University Paris 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