{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T12:43:21Z","timestamp":1789908201732,"version":"4.0.1"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,12,30]],"date-time":"2013-12-30T00:00:00Z","timestamp":1388361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG\u2010020591"],"award-info":[{"award-number":["AG\u2010020591"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 AG021890"],"award-info":[{"award-number":["T32 AG021890"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:p>\n                    Deletion of copper\u2010zinc superoxide dismutase (CuZnSOD) in\n                    <jats:italic>\n                      Sod1\n                      <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    <\/jats:italic>\n                    mice leads to accelerated loss of muscle mass and force during aging, but the losses do not occur with muscle\u2010specific deletion of CuZnSOD. To determine the role of motor neurons in the muscle decline, we generated transgenic\n                    <jats:italic>\n                      Sod1\n                      <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    <\/jats:italic>\n                    mice in which CuZnSOD was expressed under control of the synapsin 1 promoter (\n                    <jats:italic>\n                      SynTgSod1\n                      <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    <\/jats:italic>\n                    mice).\n                    <jats:italic>\n                      SynTgSod1\n                      <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    <\/jats:italic>\n                    mice expressed CuZnSOD in brain, spinal cord, and peripheral nerve, but not in other tissues. Sciatic nerve CuZnSOD content in\n                    <jats:italic>\n                      SynTgSod1\n                      <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    <\/jats:italic>\n                    mice was ~20% that of control mice, but no reduction in muscle mass or isometric force was observed in\n                    <jats:italic>\n                      SynTg\u2010Sod1\n                      <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    <\/jats:italic>\n                    mice compared with control animals, whereas muscles of age\u2010matched\n                    <jats:italic>\n                      Sod1\n                      <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    <\/jats:italic>\n                    mice displayed 30\u201340% reductions in mass and force. In addition, increased oxidative damage and adaptations in stress responses observed in muscles of\n                    <jats:italic>\n                      Sod1\n                      <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    <\/jats:italic>\n                    mice were absent in\n                    <jats:italic>\n                      SynTgSod1\n                      <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    <\/jats:italic>\n                    mice, and degeneration of neuromuscular junction (NMJ) structure and function occurred in\n                    <jats:italic>\n                      Sod1\n                      <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    <\/jats:italic>\n                    mice but not in\n                    <jats:italic>\n                      SynTgSod1\n                      <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    <\/jats:italic>\n                    mice. Our data demonstrate that specific CuZnSOD expression in neurons is sufficient to preserve NMJ and skeletal muscle structure and function in\n                    <jats:italic>\n                      Sod1\n                      <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    <\/jats:italic>\n                    mice and suggest that redox homeostasis in motor neurons plays a key role in initiating sarcopenia during aging.\u2014Sakellariou, G. K., Davis, C. S., Shi, Y., Ivannikov, M. V., Zhang, Y., Vasilaki, A., Macleod, G. T., Richardson, A., Van Remmen, H., Jackson, M. J., McArdle, A., Brooks, S. V. Neuron\u2010specific expression of CuZnSOD prevents the loss of muscle mass and function that occurs in homozygous CuZnSOD\u2010knockout mice.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    28, 1666\u20101681 (2014).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.13-240390","type":"journal-article","created":{"date-parts":[[2013,12,30]],"date-time":"2013-12-30T21:50:58Z","timestamp":1388440258000},"page":"1666-1681","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":85,"title":["Neuron\u2010specific expression of CuZnSOD prevents the loss of muscle mass and function that occurs in homozygous CuZnSOD\u2010knockout mice"],"prefix":"10.1096","volume":"28","author":[{"given":"Giorgos K.","family":"Sakellariou","sequence":"first","affiliation":[{"name":"Medical Research Council\u2013Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing (CIMA), Department of Musculoskeletal Biology Institute of Ageing and Chronic Disease, University of Liverpool Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol S.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Molecular and Integrative Physiology University of Michigan Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Cellular and Structural Biology University of Texas Health Science Center San Antonio Texas USA"},{"name":"Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxim V.","family":"Ivannikov","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Texas Health Science Center San Antonio Texas USA"},{"name":"Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Texas Health Science Center San Antonio Texas USA"},{"name":"Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aphrodite","family":"Vasilaki","sequence":"additional","affiliation":[{"name":"Medical Research Council\u2013Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing (CIMA), Department of Musculoskeletal Biology Institute of Ageing and Chronic Disease, University of Liverpool Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory T.","family":"Macleod","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Texas Health Science Center San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arlan","family":"Richardson","sequence":"additional","affiliation":[{"name":"Medical Research Council\u2013Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing (CIMA), Department of Musculoskeletal Biology Institute of Ageing and Chronic Disease, University of Liverpool Liverpool UK"},{"name":"Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly","family":"Van Remmen","sequence":"additional","affiliation":[{"name":"Department of Cellular and Structural Biology University of Texas Health Science Center San Antonio 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