{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:37:01Z","timestamp":1791297421074,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,12,16]],"date-time":"2013-12-16T00:00:00Z","timestamp":1387152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:p>\n                    Teneurin\u20104 (Ten\u20104), a transmembrane protein, is highly expressed in the central nervous system; however, its cellular and molecular function in neuronal differentiation remains unknown. In this study, we aimed to elucidate the function of Ten\u20104 in neurite outgrowth. Ten\u20104 expression was induced during neurite outgrowth of the neuroblastoma cell line Neuro\u20102a. Ten\u20104 protein was localized at the neurite growth cones. Knockdown of Ten\u20104 expression in Neuro\u20102a cells decreased the formation of the filopodia\u2010like protrusions and the length of individual neurites. Conversely, overexpression of Ten\u20104 promoted filopodia\u2010like protrusion formation. In addition, knockdown and overexpression of Ten\u20104 reduced and elevated the activation of focal adhesion kinase (FAK) and Rho\u2010family small GTPases, Cdc42 and Rac1, key molecules for the membranous protrusion formation downstream of FAK, respectively. Inhibition of the activation of FAK and neural Wiskott\u2010Aldrich syndrome protein (N\u2010WASP), which is a downstream regulator of FAK and Cdc42, blocked protrusion formation by Ten\u20104 overexpression. Further, Ten\u20104 colocalized with phosphorylated FAK in the filopodia\u2010like protrusion regions. Together, our findings show that Ten\u20104 is a novel positive regulator of cellular protrusion formation and neurite outgrowth through the FAK signaling pathway.\u2014Suzuki, N., Numakawa, T., Chou, J., de Vega, S., Mizuniwa, C., Sekimoto, K., Adachi, N., Kunugi, H., Arikawa\u2010Hirasawa, E., Yamada, Y., Akazawa, C. Teneurin\u20104 promotes cellular protrusion formation and neurite outgrowth through focal adhesion kinase signaling.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    28, 1386\u20131397 (2014).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.13-241034","type":"journal-article","created":{"date-parts":[[2013,12,16]],"date-time":"2013-12-16T22:17:38Z","timestamp":1387232258000},"page":"1386-1397","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Teneurin\u20104 promotes cellular protrusion formation and neurite outgrowth through focal adhesion kinase signaling"],"prefix":"10.1096","volume":"28","author":[{"given":"Nobuharu","family":"Suzuki","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Biophysics Graduate 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