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Secreted frizzled\u2010related protein 1 (SFRP1) is a critical molecule involved in alveolar duct formation in the lung and here we demonstrate its importance in controlling cell differentiation during lung injury. Mice lacking SFRP1 exhibited a rapid repair response leading to aberrant proliferation of differentiated cells. Furthermore, SFRP1 treatment of BASCs maintained these cells in a quiescent state.\n                    <jats:italic>In vivo<\/jats:italic>\n                    overexpression of SFRP1 after injury suppressed differentiation and resulted in the accumulation of BASCs correlating with\n                    <jats:italic>in vitro<\/jats:italic>\n                    studies. These findings suggest that SFRP1 expression in the adult maintains progenitor cells within their undifferentiated state and suggests that manipulation of this pathway is a potential target to augment the lung repair process during disease.\u2014Shiomi, T., Sklepkiewicz, P., Bodine, P. V. N., D'Armiento, J. M., Maintenance of the bronchial alveolar stem cells in an undifferentiated state by secreted frizzled\u2010related protein 1. FASEB J. 28, 5242\u20135249 (2014).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.13-242735","type":"journal-article","created":{"date-parts":[[2014,9,11]],"date-time":"2014-09-11T22:24:10Z","timestamp":1410474250000},"page":"5242-5249","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Maintenance of the bronchial alveolar stem cells in an undifferentiated state by secreted frizzled\u2010related protein 1"],"prefix":"10.1096","volume":"28","author":[{"given":"Takayuki","family":"Shiomi","sequence":"first","affiliation":[{"name":"Department of Anesthesiology College of Physicians and Surgeons Columbia University New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr","family":"Sklepkiewicz","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology College of Physicians and Surgeons Columbia University New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter V. 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