{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:47:32Z","timestamp":1761698852268,"version":"build-2065373602"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,3,5]],"date-time":"2014-03-05T00:00:00Z","timestamp":1393977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21\u201010290"],"award-info":[{"award-number":["21\u201010290"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The hypoxia\u2010inducible factors HIF\u20101\u03b1 or HIF\u20102\u03b1 form heterodimeric complexes with the aryl hydrocarbon receptor nuclear translocator (ARNT). HIF\u20101\u03b1\/ARNT and HIF\u20102\u03b1\/ARNT complexes activate hypoxia\u2010inducible genes that play critical roles in angiogenesis, anaerobic metabolism, and other processes in response to O\n                    <jats:sub>2<\/jats:sub>\n                    deprivation. HIF\u20102\u03b1 is known to regulate the function and\/or differentiation of stem cells by activating the POU domain transcription factor Oct4; however, the precise underlying mechanism is unknown. This study examined the role of HIF\u20102\u03b1\/ARNT in hair development using conditional\u2010knockout mice, in which\n                    <jats:italic>Arnt<\/jats:italic>\n                    was specifically deleted in keratinocytes. In wild\u2010type mice, HIF\u20102\u03b1 and ARNT were highly expressed in the precortex above the hair matrix, an area containing differentiating stem cells. An analysis of hair size and type in these mice showed that loss of ARNT decreased the production of zigzag hairs, corresponding to reduced expression of HIF\u20102\u03b1 and induction of the mammalian cyclin\u2010dependent kinase inhibitors p21\n                    <jats:sup>Waf1\/Cip1<\/jats:sup>\n                    <jats:italic>and<\/jats:italic>\n                    p27\n                    <jats:sup>Kip1<\/jats:sup>\n                    The results suggest that the HIF\u20102\u03b1\/ARNT complex regulates hair follicle differentiation\n                    <jats:italic>via<\/jats:italic>\n                    induction of p21\n                    <jats:sup>Waf1\/Cip1<\/jats:sup>\n                    and possibly p27\n                    <jats:sup>Kip1<\/jats:sup>\n                    , as p27\n                    <jats:sup>Kip1<\/jats:sup>\n                    expression was not altered in ARNT knockout mice. The findings provide insight into a possible mechanism underlying hair growth disorders and can be useful for future studies on hair follicle response to insults, such as chemotherapy and ionizing radiation.\u2014Imamura, Y., Tomita, S., Imanishi, M., Kihira, Y., Ikeda, Y., Ishizawa, K., Tsuchiya, K., Tamaki, T. HIF\u20102\u03b1\/ARNT complex regulates hair development\n                    <jats:italic>via<\/jats:italic>\n                    induction of p21\n                    <jats:sup>Waf1\/Cip1<\/jats:sup>\n                    and p27\n                    <jats:sup>Kip1<\/jats:sup>\n                    .\n                    <jats:italic>FASEB J<\/jats:italic>\n                    . 28, 2517\u20132524 (2014).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.13-244079","type":"journal-article","created":{"date-parts":[[2014,3,5]],"date-time":"2014-03-05T22:33:44Z","timestamp":1394058824000},"page":"2517-2524","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["HIF\u20102\u03b1\/ARNT complex regulates hair development\n                    <i>via<\/i>\n                    induction of p21\n                    <sup>Waf1\/Cip1<\/sup>\n                    and p27\n                    <sup>Kip1<\/sup>"],"prefix":"10.1096","volume":"28","author":[{"given":"Yuko","family":"Imamura","sequence":"first","affiliation":[{"name":"Department of Pharmacology Institute of Health Biosciences University of Tokushima Graduate School Tokushima Japan"},{"name":"Department of Molecular Biotechnology Graduate School of Advanced Sciences Hiroshima University Higashihiroshima City Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuhei","family":"Tomita","sequence":"additional","affiliation":[{"name":"Division of Molecular Pharmacology Tottori University Faculty of Medicine Yonago Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Imanishi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Institute of Health Biosciences University of Tokushima Graduate School Tokushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitaka","family":"Kihira","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Institute of Health Biosciences University of Tokushima Graduate School Tokushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasumasa","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Institute of Health Biosciences University of Tokushima Graduate School Tokushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Ishizawa","sequence":"additional","affiliation":[{"name":"Department of Medical Pharmacology Institute of Health Biosciences University of Tokushima Graduate School Tokushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichiro","family":"Tsuchiya","sequence":"additional","affiliation":[{"name":"Department of Medical Pharmacology Institute of Health Biosciences University of Tokushima Graduate School Tokushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiaki","family":"Tamaki","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Institute of Health Biosciences University of Tokushima Graduate School Tokushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,3,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.12.5510"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4914(01)02090-1"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.12.12.5447"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/20459"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1187"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601300"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.13.5675-5686.2005"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.23.24.9361-9374.2003"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3183"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1086903"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(01)00022-3"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg758"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.01670.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0706949104"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90500-P"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90499-G"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/366701a0"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1994.1063"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.02.045"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012038"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/32925"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.122347199"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2008.192"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.14.10.1674"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.14.7400"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2089"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005803"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000172622.51973.f5"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2011.07.009"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.03282"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200318513"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05659"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1958.121"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33703"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1999.00797.x"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/222288a0"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2005.06.009"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0608899103"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.2.149"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/386403a0"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.140087397"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700874"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.13-244079","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1096\/fj.13-244079","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.13-244079","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T20:57:56Z","timestamp":1761685076000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.13-244079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,5]]},"references-count":42,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1096\/fj.13-244079"],"URL":"https:\/\/doi.org\/10.1096\/fj.13-244079","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"type":"print","value":"0892-6638"},{"type":"electronic","value":"1530-6860"}],"subject":[],"published":{"date-parts":[[2014,3,5]]},"assertion":[{"value":"2013-10-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-02-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-03-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}