{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T01:22:43Z","timestamp":1793755363868,"version":"4.6.1"},"reference-count":212,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,2,20]],"date-time":"2014-02-20T00:00:00Z","timestamp":1392854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Serotonin and vitamin D have been proposed to play a role in autism; however, no causal mechanism has been established. Here, we present evidence that vitamin D hormone (calcitriol) activates the transcription of the serotonin\u2010synthesizing gene tryptophan hydroxylase 2 (\n                    <jats:italic>TPH2<\/jats:italic>\n                    ) in the brain at a vitamin D response element (VDRE) and represses the transcription of\n                    <jats:italic>TPH1<\/jats:italic>\n                    in tissues outside the blood\u2010brain barrier at a distinct VDRE. The proposed mechanism explains 4 major characteristics associated with autism: the low concentrations of serotonin in the brain and its elevated concentrations in tissues outside the blood\u2010brain barrier; the low concentrations of the vitamin D hormone precursor 25\u2010hydroxyvitamin D [25(OH)D\n                    <jats:sub>3<\/jats:sub>\n                    ]; the high male prevalence of autism; and the presence of maternal antibodies against fetal brain tissue. Two peptide hormones, oxytocin and vasopressin, are also associated with autism and genes encoding the oxytocin\u2010neurophysin I preproprotein, the oxytocin receptor, and the arginine vasopressin receptor contain VDREs for activation. Supplementation with vitamin D and tryptophan is a practical and affordable solution to help prevent autism and possibly ameliorate some symptoms of the disorder.\u2014Patrick, R. P., Ames, B. N. Vitamin D hormone regulates serotonin synthesis. Part 1: relevance for autism.\n                    <jats:italic>FASEB J<\/jats:italic>\n                    . 28, 2398\u20132413 (2014).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.13-246546","type":"journal-article","created":{"date-parts":[[2014,2,20]],"date-time":"2014-02-20T21:44:05Z","timestamp":1392932645000},"page":"2398-2413","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":337,"title":["Vitamin D hormone regulates serotonin synthesis. Part 1: relevance for autism"],"prefix":"10.1096","volume":"28","author":[{"given":"Rhonda P.","family":"Patrick","sequence":"first","affiliation":[{"name":"Nutrition and Metabolism Center Children's Hospital Oakland Research Institute Oakland California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce N.","family":"Ames","sequence":"additional","affiliation":[{"name":"Nutrition and Metabolism Center Children's Hospital Oakland Research Institute Oakland California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,2,20]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_13_3_1","first-page":"1","volume-title":"Centers for Disease Control and Prevention: Morbidity and Mortality Weekly Report (MMWR)","author":"Baio J.","year":"2012"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.1.87"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds301"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.05.025"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.76"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.1977.tb00443.x"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700028099"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.2174\/157015909788848848"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-200212000-00025"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.2.3.268"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(97)00532-5"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-006-0324-6"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-200404000-00016"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2006.08.026"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.04150.x"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30720"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.11.007"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000873"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30168"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2012.05.012"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0048975"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.12.095"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/2040-2392-4-16"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(03)00556-2"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2008.12.005"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-10-052787"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09972"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-16-06348.2001"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(77)90057-9"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-6663(86)80055-1"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.178.4059.414"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.04506.x"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1989.01810030019003"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(199903)45:3<287::AID-ANA3>3.0.CO;2-9"},{"key":"e_1_2_13_37_1","doi-asserted-by":"crossref","first-page":"7594","DOI":"10.1523\/JNEUROSCI.14-12-07594.1994","article-title":"Effect of serotonin depletion on vibrissa-related patterns of thalamic afferents in the rat's somatosensory cortex","volume":"14","author":"Bennett-Clarke C. A.","year":"1994","journal-title":"J. Neurosci."},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)00297-7"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.3.428"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1159\/000258640"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2005-0106"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.07-9326rev"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/87.4.1080S"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.4065\/81.3.353"},{"key":"e_1_2_13_45_1","doi-asserted-by":"crossref","first-page":"554S","DOI":"10.1093\/ajcn\/88.2.554S","article-title":"Analyzing vitamin D in foods and supplements: methodologic challenges","volume":"88","author":"Byrdwell W. C.","year":"2008","journal-title":"Am. J. Clin. Nutr."},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0385"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.2835"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-0195"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.4065\/mcp.2010.0138"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2008.604"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1306357"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030773"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jand.2012.01.026"},{"key":"e_1_2_13_54_1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.4161\/derm.22942","article-title":"Autism prevalence in the United States with respect to solar UV-B doses: an ecological study","volume":"5","author":"Grant W. B.","year":"2013","journal-title":"Dermatoendocrinol."},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2007.08.016"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.4161\/derm.1.4.9500"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.162.11.1026"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-2644"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-012-1676-8"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-011-1324-8"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2010.03812.x"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2008.03036.x"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2010.01755.x"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114511007161"},{"key":"e_1_2_13_65_1","volume-title":"Autism Spectrum Disorders Among Preschool Children Participating in the Minneapolis Public Schools Early Childhood Special Education Programs","author":"Minnesota Department of Health","year":"2009"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038893"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.111.095125"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.109.065490"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/80.6.1678S"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-200212000-00016"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2007.131243"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1097\/DBP.0b013e31820b4260"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.3109\/17518423.2011.566596"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1097\/DBP.0b013e318165c7a0"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-008-0611-5"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.157.9.867"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1037\/1099-9809.13.1.18"},{"key":"e_1_2_13_78_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-1474"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0011551"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-006-0194-y"},{"key":"e_1_2_13_81_1","volume-title":"Nuclear Vitamin D Receptor: Structure-Function, Molecular Control of Gene Transcription, and Novel Bioactions","author":"Whitfield G. K.","year":"2005"},{"key":"e_1_2_13_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2011.05.010"},{"key":"e_1_2_13_83_1","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1210\/mend.13.3.0249","article-title":"Turning a negative into a positive: vitamin D receptor interactions with the avian parathyroid hormone response element","volume":"13","author":"Koszewski N. J.","year":"1999","journal-title":"Mol. Endocrinol."},{"key":"e_1_2_13_84_1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1530\/JOE-13-0212","article-title":"Vitamin D receptor-mediated control of Soggy, Wise, and Hairless gene expression in keratinocytes","volume":"220","author":"Hsieh J. C.","year":"2013","journal-title":"J. Endocrinol."},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2008.07.002"},{"key":"e_1_2_13_86_1","doi-asserted-by":"crossref","first-page":"369","DOI":"10.3181\/00379727-199-43371","article-title":"1,25-Dihydroxyvitamin D and not calcium is the major regulator of calbindin-D 9-kDa mRNA levels in vivo","volume":"199","author":"Strom M.","year":"1992","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"e_1_2_13_87_1","doi-asserted-by":"crossref","first-page":"27371","DOI":"10.1016\/S0021-9258(19)74259-8","article-title":"Cloning of the promoter for the avian integrin beta 3 subunit gene and its regulation by 1,25-dihydroxyvitamin D3","volume":"268","author":"Cao X.","year":"1993","journal-title":"J. Biol. Chem."},{"key":"e_1_2_13_88_1","doi-asserted-by":"publisher","DOI":"10.1139\/o05-057"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2008.00093.x"},{"key":"e_1_2_13_90_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0b013e3281c55f16"},{"key":"e_1_2_13_91_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkm179"},{"key":"e_1_2_13_92_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.27.16310"},{"key":"e_1_2_13_93_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3006286"},{"key":"e_1_2_13_94_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1117792109"},{"key":"e_1_2_13_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2098"},{"key":"e_1_2_13_96_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-012-1709-3"},{"key":"e_1_2_13_97_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-007-0453-6"},{"key":"e_1_2_13_98_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1999.0722065.x"},{"key":"e_1_2_13_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11737-5"},{"key":"e_1_2_13_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(92)90106-A"},{"key":"e_1_2_13_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(97)00340-5"},{"key":"e_1_2_13_102_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0065785"},{"key":"e_1_2_13_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2013.04.010"},{"key":"e_1_2_13_104_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.01959.x"},{"key":"e_1_2_13_105_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2009.06986.x"},{"key":"e_1_2_13_106_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.04264.x"},{"key":"e_1_2_13_107_1","doi-asserted-by":"publisher","DOI":"10.1177\/1362361307076857"},{"key":"e_1_2_13_108_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-21-07021.1996"},{"key":"e_1_2_13_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.10.019"},{"key":"e_1_2_13_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278-5846(88)90061-9"},{"key":"e_1_2_13_111_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01252033"},{"key":"e_1_2_13_112_1","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1007\/BF00238968","article-title":"Sex differences in long-term gonadectomized rats: monoamine levels and [3H] nitroimipramine binding in brain nuclei","volume":"58","author":"Renner K. J.","year":"1985","journal-title":"Exp. Brain Res."},{"key":"e_1_2_13_113_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt1973142277"},{"key":"e_1_2_13_114_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00561141"},{"key":"e_1_2_13_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(73)90287-4"},{"key":"e_1_2_13_116_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00172108"},{"key":"e_1_2_13_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbrainres.2004.12.011"},{"key":"e_1_2_13_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(99)00156-0"},{"key":"e_1_2_13_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2010.12.019"},{"key":"e_1_2_13_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(96)00233-1"},{"key":"e_1_2_13_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(99)00243-0"},{"key":"e_1_2_13_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90020-Y"},{"key":"e_1_2_13_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2011.01.002"},{"key":"e_1_2_13_124_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-06-0078"},{"key":"e_1_2_13_125_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-50-1-117"},{"key":"e_1_2_13_126_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590400018231"},{"key":"e_1_2_13_127_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-9280.2009.02279.x"},{"key":"e_1_2_13_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(99)00082-0"},{"key":"e_1_2_13_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2010.08.004"},{"key":"e_1_2_13_130_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06548"},{"key":"e_1_2_13_131_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2013.47"},{"key":"e_1_2_13_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2013.01.084"},{"key":"e_1_2_13_133_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2013.101"},{"key":"e_1_2_13_134_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2013.50"},{"key":"e_1_2_13_135_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5380.1191"},{"key":"e_1_2_13_136_1","doi-asserted-by":"publisher","DOI":"10.1038\/83183"},{"key":"e_1_2_13_137_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2004.02441.x"},{"key":"e_1_2_13_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2005.11.008"},{"key":"e_1_2_13_139_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903670"},{"key":"e_1_2_13_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2006.09.017"},{"key":"e_1_2_13_141_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.11.6752"},{"key":"e_1_2_13_142_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2077"},{"key":"e_1_2_13_143_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1835-05.2006"},{"key":"e_1_2_13_144_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja076186k"},{"key":"e_1_2_13_145_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-010-0161-8"},{"key":"e_1_2_13_146_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3327-12.2012"},{"key":"e_1_2_13_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.09.025"},{"key":"e_1_2_13_148_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2008.01726.x"},{"key":"e_1_2_13_149_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12518"},{"key":"e_1_2_13_150_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3465"},{"key":"e_1_2_13_151_1","first-page":"301","article-title":"Social effects of oxytocin in humans: context and person matter","volume":"15","author":"Bartz J. A.","year":"2011","journal-title":"Trends Cogn. Sci."},{"key":"e_1_2_13_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(97)00439-3"},{"key":"e_1_2_13_153_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0910249107"},{"key":"e_1_2_13_154_1","doi-asserted-by":"publisher","DOI":"10.1186\/2040-2392-4-22"},{"key":"e_1_2_13_155_1","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/npp.2013.254","article-title":"Oxytocin promotes facial emotion recognition and amygdala reactivity in adults with asperger syndrome","volume":"39","author":"Domes G.","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"e_1_2_13_156_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300021"},{"key":"e_1_2_13_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.05.030"},{"key":"e_1_2_13_158_1","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1042\/bj3520301","article-title":"All natural DR3-type vitamin D response elements show a similar functionality in vitro","volume":"352","author":"Toell A.","year":"2000","journal-title":"Biochem. J."},{"key":"e_1_2_13_159_1","first-page":"543","article-title":"1.25-Dihydroxyvitamin D3 receptor is partly colocalized with oxytocin immunoreactivity in neurons of the male rat hypothalamus","volume":"43","author":"Prufer K.","year":"1997","journal-title":"Cell. Mol. Biol. (Noisy-le-grand)"},{"key":"e_1_2_13_160_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300360"},{"key":"e_1_2_13_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2006.09.009"},{"key":"e_1_2_13_162_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02539"},{"key":"e_1_2_13_163_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001503"},{"key":"e_1_2_13_164_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001125"},{"key":"e_1_2_13_165_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001812"},{"key":"e_1_2_13_166_1","doi-asserted-by":"publisher","DOI":"10.1186\/2040-2392-2-3"},{"key":"e_1_2_13_167_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2008.54"},{"key":"e_1_2_13_168_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5294-11.2012"},{"key":"e_1_2_13_169_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1421"},{"key":"e_1_2_13_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2010.10.028"},{"key":"e_1_2_13_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2011.07.013"},{"key":"e_1_2_13_172_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-002-0071-6"},{"key":"e_1_2_13_173_1","first-page":"268","article-title":"Serotonin is a sword and a shield of the bowel: serotonin plays offense and defense","volume":"123","author":"Gershon M. D.","year":"2012","journal-title":"Trans. Am. Clin. Climatol. Assoc."},{"key":"e_1_2_13_174_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.08.041"},{"key":"e_1_2_13_175_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1256"},{"key":"e_1_2_13_176_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2006.105577"},{"key":"e_1_2_13_177_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2010.01662.x"},{"key":"e_1_2_13_178_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/137.2.447"},{"key":"e_1_2_13_179_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e318227f06b"},{"key":"e_1_2_13_180_1","volume-title":"Dietary Reference Intakes for Calcium and Vitamin D","author":"Ross A. C.","year":"2013"},{"key":"e_1_2_13_181_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.112.034256"},{"key":"e_1_2_13_182_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/72.3.690"},{"key":"e_1_2_13_183_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.evolhumbehav.2004.10.002"},{"key":"e_1_2_13_184_1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1097\/WNR.0000000000000034","article-title":"Serum 25-hydroxyvitamin D levels in Chinese children with autism spectrum disorders","volume":"25","author":"Gong Z. L.","year":"2013","journal-title":"Neuroreport"},{"key":"e_1_2_13_185_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-006-0320-x"},{"key":"e_1_2_13_186_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cnr.2006.08.001"},{"key":"e_1_2_13_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2011.07.033"},{"key":"e_1_2_13_188_1","doi-asserted-by":"publisher","DOI":"10.1016\/0753-3322(96)82645-X"},{"key":"e_1_2_13_189_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1996.01830110029004"},{"key":"e_1_2_13_190_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2012.513"},{"key":"e_1_2_13_191_1","doi-asserted-by":"publisher","DOI":"10.1139\/Y07-082"},{"key":"e_1_2_13_192_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(01)00219-6"},{"key":"e_1_2_13_193_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2005.06.004"},{"key":"e_1_2_13_194_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-200204000-00012"},{"key":"e_1_2_13_195_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v67n0311"},{"key":"e_1_2_13_196_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2007.10.009"},{"key":"e_1_2_13_197_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2008.05.013"},{"key":"e_1_2_13_198_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.05.007"},{"key":"e_1_2_13_199_1","first-page":"36","article-title":"The effect of essential fatty acid supplementation on language development and learning skills in autism and Asperger's syndrome","author":"Patrick L.","year":"2005","journal-title":"Autism Asperger's Digest"},{"key":"e_1_2_13_200_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/137.4.855"},{"key":"e_1_2_13_201_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000160542.69840.0F"},{"key":"e_1_2_13_202_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kws433"},{"key":"e_1_2_13_203_1","doi-asserted-by":"publisher","DOI":"10.1054\/plef.2001.0281"},{"key":"e_1_2_13_204_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2004.03.008"},{"key":"e_1_2_13_205_1","doi-asserted-by":"publisher","DOI":"10.1089\/cap.2012.0127"},{"key":"e_1_2_13_206_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1997.tb07437.x"},{"key":"e_1_2_13_207_1","first-page":"46","article-title":"Improvement of neurobehavioral disorders in children supplemented with magnesium-vitamin B6. I. Attention deficit hyperactivity disorders","volume":"19","author":"Mousain-Bosc M.","year":"2006","journal-title":"Magn. Res."},{"key":"e_1_2_13_208_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2002.tb00809.x"},{"key":"e_1_2_13_209_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02212198"},{"key":"e_1_2_13_210_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0608757103"},{"key":"e_1_2_13_211_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.27930"},{"key":"e_1_2_13_212_1","article-title":"Prevention of mutation, cancer, and other age-associated diseases by optimizing micronutrient intake","author":"Ames B. N.","year":"2010","journal-title":"J. Nucleic Acids"},{"key":"e_1_2_13_213_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11-180885"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.13-246546","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1096\/fj.13-246546","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.13-246546","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T20:57:15Z","timestamp":1761685035000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.13-246546"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,20]]},"references-count":212,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1096\/fj.13-246546"],"URL":"https:\/\/doi.org\/10.1096\/fj.13-246546","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,20]]},"assertion":[{"value":"2013-11-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-02-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-02-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}