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Here, we investigated anti\u2010inflammatory and proresolving actions of RvD1 after oral administration. RvD1 rapidly accumulated in the mouse plasma after oral delivery and dose\u2010dependently (1\u2013100 ng\/mouse) reduced leukocyte infiltration in zymosan A\u2010induced acute peritonitis. Using mathematical resolution indices, RvD1 reduced \u03a8\n                    <jats:sub>max<\/jats:sub>\n                    by ~50%, shortened the resolution interval by 3 h, and significantly reduced total leukocyte (by ~30\u201345%) and polymorphonuclear neutrophil (by ~40\u201355%) accumulation when administered at the peak of peritonitis. RvD1 also improved course and outcome of severe peritonitis, shifting it toward resolution. In peritoneal macrophages (M\u03a6s) from the resolution phase of peritonitis, RvD1 down\u2010regulated (by 2\u2010 to 3\u2010fold) select genes that control gene transcription, namely coactivator\u2010associated arginine methyltransferase 1 (CARM1), and downstream genes, such as colony\u2010stimulating factor 3, intercellular adhesion molecule 1, and monocyte inflammatory protein 2, which promote neutrophil infiltration and reduce M\u03a6 phagocytosis. Congruently, CARM1 knockdown in human and murine M\u03a6s induced a proresolving phenotype, recapitulating\n                    <jats:italic>in vivo<\/jats:italic>\n                    actions of RvD1. These results establish novel properties of RvD1 and demonstrate that RvD1 modifies the transcription control machinery in M\u03a6s, as part of its mechanisms of action during the resolution of acute inflammation.\u2014Recchiuti, A., Codagnone, M., Pierdomenico, A. M., Rossi, C., Mari, V. C., Cianci, E., Simiele, F., Gatta, V., Romano, M. Immunoresolving actions of oral resolvin D1 include selective regulation of the transcription machinery in resolution\u2010phase mouse macrophages.\n                    <jats:italic>FASEB J<\/jats:italic>\n                    . 28, 3090\u20133102 (2014).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.13-248393","type":"journal-article","created":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T21:43:53Z","timestamp":1396388633000},"page":"3090-3102","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Immunoresolving actions of oral resolvin D1 include selective regulation of the transcription machinery in resolution\u2010phase mouse macrophages"],"prefix":"10.1096","volume":"28","author":[{"given":"Antonio","family":"Recchiuti","sequence":"first","affiliation":[{"name":"Department of Experimental and Clinical Science G. d'Annunzio University Chieti Italy"},{"name":"Center of Excellence on Aging G. d'Annunzio University Foundation Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilina","family":"Codagnone","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Science G. d'Annunzio University Chieti Italy"},{"name":"Center of Excellence on Aging G. d'Annunzio University Foundation Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Maria","family":"Pierdomenico","sequence":"additional","affiliation":[{"name":"Department of Medicine and Aging Science G. d'Annunzio University Chieti Italy"},{"name":"Center of Excellence on Aging G. d'Annunzio University Foundation Chieti 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