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ShK\u2010186, a selective inhibitor of Kv1.3 channels, ameliorates autoimmune diseases in rodent models, and human phase 1 trials of this agent in healthy volunteers have been completed. In this study, we identified and characterized a large family of\n                    <jats:italic>Stichodactyla helianthus<\/jats:italic>\n                    toxin (ShK)\u2010related peptides in parasitic worms. Based on phylogenetic analysis, 2 worm peptides were selected for study: AcK1, a 51\u2010residue peptide expressed in the anterior secretory glands of the dog\u2010infecting hookworm\n                    <jats:italic>Ancylostoma caninum<\/jats:italic>\n                    and the human\u2010infecting hookworm\n                    <jats:italic>Ancylostoma ceylanicum<\/jats:italic>\n                    , and BmK1, the C\u2010terminal domain of a metalloprotease from the filarial worm\n                    <jats:italic>Brugia malayi.<\/jats:italic>\n                    These peptides in solution adopt helical structures closely resembling that of ShK. At doses in the nanomolar\u2010micromolar range, they block native Kv1.3 in human T cells and cloned Kv1.3 stably expressed in L929 mouse fibroblasts. They preferentially suppress the proliferation of rat CCR7\n                    <jats:sup>\u2010<\/jats:sup>\n                    effector memory T cells without affecting naive and central memory subsets and inhibit the delayed\u2010type hypersensitivity (DTH) response caused by skin\u2010homing effector memory T cells in rats. Further, they suppress IFN\u03b3 production by human T lymphocytes. ShK\u2010related peptides in parasitic worms may contribute to the potential beneficial effects of probiotic parasitic worm therapy in human autoimmune diseases.\u2014Chhabra, S., Chang, S. C., Nguyen, H. M., Huq, R., Tanner, M. R., Londono, L. M., Estrada, R., Dhawan, V., Chauhan, S., Upadhyay, S. K., Gindin, M., Hotez, P. J., Valenzuela, J. G., Mohanty, B., Swarbrick, J. D., Wulff, H., Iadonato, S. P., Gutman, G. A., Beeton, C., Pennington, M. W., Norton, R. S., Chandy, K. G. 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