{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T08:46:04Z","timestamp":1778661964039,"version":"3.51.4"},"reference-count":48,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,8,13]],"date-time":"2014-08-13T00:00:00Z","timestamp":1407888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:p>\n                    In the present bed rest (BR) study, 23 volunteers were randomized into 3 subgroups: 60 d BR control (Ctr); BR with resistive exercise (RE; lower\u2010limb load); and resistive vibration exercise (RVE; RE with superimposed vibration). The aim was to analyze by confocal and electron microscopy the effects of vibration on myofibril and filament integrity in soleus (Sol) and vastus lateralis (VL) muscle; differential proteomics of contractile, cytoskeletal, and costameric proteins (TN\u2010C, ROCK1, and FAK); and expression of PGC1a and atrophy\u2010related master genes MuRF1 and MuRF2. RVE (but not RE) preserved myofiber size and phenotype in Sol and VL by overexpressing MYBPC1 (42%,\n                    <jats:italic>P<\/jats:italic>\n                    \u22640.01), WDR1 (39%,\n                    <jats:italic>P<\/jats:italic>\n                    \u22640.01), sarcosin (84%,\n                    <jats:italic>P<\/jats:italic>\n                    \u22640.01), and CKM (20%,\n                    <jats:italic>P<\/jats:italic>\n                    \u22640.01) and prevented myofibrillar ultrastructural damage as detectable by MuRF1 expression. In Sol, cytoskeletal and contractile proteins were normalized by RVE, and TN\u2010C increased (59%,\n                    <jats:italic>P<\/jats:italic>\n                    \u22640.01); the latter also with RE (108%,\n                    <jats:italic>P<\/jats:italic>\n                    \u22640.01). In VL, the outcomes of both RVE (acting on sarcosin and desmin) and RE (by way of troponinT\u2010slow and MYL2) were similar. RVE appears to be a highly efficient countermeasure protocol against muscle atrophy and ultra\u2010structural and molecular dysregulation induced by chronic disuse.\u2014Salanova, M., Gelfi, C., Moriggi, M., Vasso, M., Vigan\u00f2, A., Minafra, L., Bonifacio, G., Schiffl, G., Gutsmann, M., Felsenberg, D., Cerretelli, P., Blottner, D., Disuse deterioration of human skeletal muscle challenged by resistive exercise superimposed with vibration: evidence from structural and proteomic analysis. FASEB J. 28, 4748\u20134763 (2014).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.14-252825","type":"journal-article","created":{"date-parts":[[2014,8,14]],"date-time":"2014-08-14T00:11:25Z","timestamp":1407975085000},"page":"4748-4763","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Disuse deterioration of human skeletal muscle challenged by resistive exercise superimposed with vibration: evidence from structural and proteomic analysis"],"prefix":"10.1096","volume":"28","author":[{"given":"Michele","family":"Salanova","sequence":"first","affiliation":[{"name":"Center of Space Medicine Berlin Neuromuscular Group Institute of Anatomy Charit\u00e9 Universit\u00e4tsmedizin Berlin Berlin 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