{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T12:04:54Z","timestamp":1792929894389,"version":"4.5.0"},"reference-count":74,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,1,8]],"date-time":"2015-01-08T00:00:00Z","timestamp":1420675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31200869"],"award-info":[{"award-number":["31200869"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81261160507"],"award-info":[{"award-number":["81261160507"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81330074"],"award-info":[{"award-number":["81330074"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81170632"],"award-info":[{"award-number":["81170632"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013314","name":"Higher Education Discipline Innovation Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013314","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK35124"],"award-info":[{"award-number":["DK35124"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:p>\n                    Water channel aquaporin\u20101 (AQP1) is expressed at epithelial cell plasma membranes in renal proximal tubules and thin descending limb of Henle. Recently, AQP1 was reported to interact with \u03b2\u2010catenin. Here we investigated the relationship between AQP1 and Wnt signaling in\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    models of autosomal dominant polycystic kidney disease (PKD). AQP1 overexpression decreased \u03b2\u2010catenin and cyclinD1 expression, suggesting down\u2010regulation of Wnt signaling, and coimmunoprecipitation showed AQP1 interaction with \u03b2\u2010catenin, glycogen synthase kinase 3\u03b2, LRP6, and Axin1. AQP1 inhibited cyst development and promoted branching in matrix\u2010grown MDCK cells. In embryonic kidney cultures, AQP1 deletion increased cyst development by up to ~40%. Kidney size and cyst number were significantly greater in AQP1\u2010null PKD mice than in AQP1\u2010expressing PKD mice, with the difference mainly attributed to a greater number of proximal tubule cysts. Biochemical analysis revealed decreased \u03b2\u2010catenin phosphorylation and increased \u03b2\u2010catenin expression in AQP1\u2010null PKD mice, suggesting enhanced Wnt signaling. These results implicate AQP1 as a novel determinant in renal cyst development that may involve inhibition of Wnt signaling by an AQP1\u2010macromolecular signaling complex.\u2014Wang, W., Li, F., Sun, Y., Lei, L., Zhou, H., Lei, T., Xia, Y., Verkman, A. S., Yang, B. Aquaporin\u20101 retards renal cyst development in polycystic kidney disease by inhibition of Wnt signaling.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    29, 1551\u20101563 (2015).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.14-260828","type":"journal-article","created":{"date-parts":[[2015,1,9]],"date-time":"2015-01-09T02:53:51Z","timestamp":1420772031000},"page":"1551-1563","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Aquaporin\u20101 retards renal cyst development in polycystic kidney disease by inhibition of Wnt signaling"],"prefix":"10.1096","volume":"29","author":[{"given":"Weiling","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pharmacology School of Basic Medical Sciences Peking University, and State Key Laboratory of Natural and Biomimetic Drugs, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Basic Medical Sciences Peking University, and State Key Laboratory of Natural and Biomimetic Drugs, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Basic Medical Sciences Peking University, and State Key Laboratory of Natural and Biomimetic Drugs, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Basic Medical Sciences Peking University, and State Key Laboratory of Natural and Biomimetic Drugs, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Basic Medical Sciences Peking University, and State Key Laboratory of Natural and Biomimetic Drugs, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianluo","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Basic Medical Sciences Peking University, and State Key Laboratory of Natural and Biomimetic Drugs, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Xia","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences The Chinese University of Hong Kong Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. S.","family":"Verkman","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Physiology University of California, San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoxue","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Basic Medical Sciences Peking University, and State Key Laboratory of Natural and Biomimetic Drugs, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.8.4296"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.079467"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3468"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.24.11663"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2009.231"},{"key":"e_1_2_7_7_1","first-page":"F587","article-title":"Evidence that aquaporin\u20101 mediates NaCl\u2010induced water flux across descending vasa recta","volume":"272","author":"Pallone T. L.","year":"1997","journal-title":"Am. J. Physiol."},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2013-0374OC"},{"key":"e_1_2_7_9_1","doi-asserted-by":"crossref","first-page":"4802","DOI":"10.1167\/iovs.07-0537","article-title":"Aquaporin\u20101 independent microvessel proliferation in a neonatal mouse model of oxygen\u2010induced retinopathy","volume":"48","author":"Ruiz\u2010Ederra J.","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03460"},{"key":"e_1_2_7_11_1","first-page":"F398","article-title":"Water channel expression in human ADPKD kidneys","volume":"268","author":"Bachinsky D. R.","year":"1995","journal-title":"Am. J. Physiol."},{"key":"e_1_2_7_12_1","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1159\/000044893","article-title":"The expression of water channels AQP1 and AQP2 in a large series of ADPKD kidneys","volume":"78","author":"Devuyst O.","year":"1998","journal-title":"Nephron"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.60.101707.125712"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2009.128"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2012070650"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00356.2011"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.87"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn039"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(02)00216-2"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200910041"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00448.2003"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00015.2004"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006030295"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000125295.43813.1F"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e11-01-0038"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.120.3.757"},{"key":"e_1_2_7_27_1","first-page":"36","article-title":"Lithium chloride regulates the proliferation of stem\u2010like cells in retinoblastoma cell lines: a potential role for the canonical Wnt signaling pathway","volume":"16","author":"Silva A. K.","year":"2010","journal-title":"Mol. Vis."},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2012.02488.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1137065"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.498444"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045976"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1094291"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm859"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2013.12.013"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1995.129"},{"key":"e_1_2_7_36_1","volume-title":"Formation and development of nephrons.","author":"Cho Eaa D. G. R.","year":"2003"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.418"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.62"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.8.4947"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e07-02-0142"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2013.0185"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.4161\/cam.4.2.10949"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006167"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn208"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2010030237"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204825"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M410697200"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2010.05.004"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.2478\/v10042-010-0017-z"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb0402-e101"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1734137100"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1718"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.23.7.2287-2297.2003"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.11.034"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e10-11-0871"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04185"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004926"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204064"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08356"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210055"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1232389"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4121"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.05.002"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2006.04.006"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.01.068"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt672"},{"key":"e_1_2_7_67_1","first-page":"233","article-title":"Cell and molecular biology of kidney development","volume":"18","author":"Orellana S. A.","year":"1998","journal-title":"Semin. Nephrol."},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcb.2010.01.002"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1998.9091"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005080846"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4226"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2008.03.004"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000136298.09488.D7"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn045"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057797"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.14-260828","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1096\/fj.14-260828","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.14-260828","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T01:10:30Z","timestamp":1761700230000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.14-260828"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,8]]},"references-count":74,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1096\/fj.14-260828"],"URL":"https:\/\/doi.org\/10.1096\/fj.14-260828","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,8]]},"assertion":[{"value":"2014-07-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-12-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-01-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}