{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:49:41Z","timestamp":1792036181263,"version":"4.4.0"},"reference-count":52,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,2,12]],"date-time":"2015-02-12T00:00:00Z","timestamp":1423699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Five fundamental taste qualities (sweet, bitter, salty, sour, umami) are sensed by dedicated taste cells (TCs) that relay quality information to gustatory nerve fibers. In peripheral taste signaling pathways, ATP has been identified as a functional neurotransmitter, but it remains to be determined how specificity of different taste qualities is maintained across synapses. Recent studies demonstrated that some gut peptides are released from taste buds by prolonged application of particular taste stimuli, suggesting their potential involvement in taste information coding. In this study, we focused on the function of glucagon\u2010like peptide\u20101 (GLP\u20101) in initial responses to taste stimulation. GLP\u20101 receptor (GLP\u20101R) null mice had reduced neural and behavioral responses specifically to sweet compounds compared to wild\u2010type (WT) mice. Some sweet responsive TCs expressed GLP\u20101 and its receptors were expressed in gustatory neurons. GLP\u20101 was released immediately from taste bud cells in response to sweet compounds but not to other taste stimuli. Intravenous administration of GLP\u20101 elicited transient responses in a subset of sweet\u2010sensitive gustatory nerve fibers but did not affect other types of fibers, and this response was suppressed by pre\u2010administration of the GLP\u20101R antagonist Exendin\u20104(3\u201039). Thus GLP\u20101 may be involved in normal sweet taste signal transmission in mice.\u2014 Takai, S., Yasumatsu, K., Inoue, M., Iwata, S., Yoshida, R., Shigemura, N., Yanagawa, Y., Drucker, D. J., Margolskee, R. F., Ninomiya, Y. Glucagon\u2010like peptide\u20101 is specifically involved in sweet taste transmission.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    29, 2268\u20102280 (2015).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.14-265355","type":"journal-article","created":{"date-parts":[[2015,2,12]],"date-time":"2015-02-12T22:18:06Z","timestamp":1423779486000},"page":"2268-2280","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":100,"title":["Glucagon\u2010like peptide\u20101 is specifically involved in sweet taste transmission"],"prefix":"10.1096","volume":"29","author":[{"given":"Shingo","family":"Takai","sequence":"first","affiliation":[{"name":"Section of Oral Neuroscience Graduate School of Dental Sciences Kyushu University Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Yasumatsu","sequence":"additional","affiliation":[{"name":"Division of Sensory Physiology Research and Development Center for Taste and Odor Sensing Kyushu University Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayuko","family":"Inoue","sequence":"additional","affiliation":[{"name":"Section of Oral Neuroscience Graduate School of Dental Sciences Kyushu University Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shusuke","family":"Iwata","sequence":"additional","affiliation":[{"name":"Section of Oral Neuroscience Graduate School of Dental Sciences Kyushu University Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryusuke","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Section of Oral Neuroscience Graduate School of Dental Sciences Kyushu University Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriatsu","family":"Shigemura","sequence":"additional","affiliation":[{"name":"Section of Oral Neuroscience Graduate School of Dental Sciences Kyushu University Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchio","family":"Yanagawa","sequence":"additional","affiliation":[{"name":"Department of Genetic and Behavioral Neuroscience Gunma University Graduate School of Medicine, and JST, CREST Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Drucker","sequence":"additional","affiliation":[{"name":"The Lunenfeld Tanenbaum Research Institute Mt. 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