{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T01:38:22Z","timestamp":1792201102549,"version":"4.4.0"},"reference-count":69,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,3,10]],"date-time":"2015-03-10T00:00:00Z","timestamp":1425945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Preterm birth is an inflammatory process resulting from the massive infiltration of innate immune cells and the production of proinflammatory cytokines in the myometrium. However, proinflammatory cytokines, which induce labor\n                    <jats:italic>in vivo<\/jats:italic>\n                    , fail to induce labor\u2010associated features in human myometrial cells (MCs). We thus aimed to investigate if reactive oxygen species (ROS) production could be the missing step between immune cell activation and MC response. Indeed, we found that ROS production is increased in the human preterm laboring myometrium (27% ROS producing cells, respectively,\n                    <jats:italic>versus<\/jats:italic>\n                    2% in nonlaboring controls), with 90% ROS production in macrophages. Using LPS\u2010stimulated myometrial samples and cell coculture experiments, we demonstrated that ROS production is required for labor onset. Furthermore, we showed that ROS are required first in the NADPH oxidase (NADPHox)\u20102\/NF\u2010\u03baB\u2010dependent macrophage response to inflammatory stimuli but, more importantly, to trigger macrophage\u2010induced MCs transactivation. Remarkably, in a murine model of LPS\u2010induced preterm labor (inducing delivery within 17 hours, with no pup survival), cotreatment with glutathione delayed labor onset up to 94 hours and prevented\n                    <jats:italic>in utero<\/jats:italic>\n                    fetal distress, allowing 46% pups to survive. These results suggest that targeting ROS production with the macrophage\u2010permeable antioxidant glutathione could constitute a promising strategy to prevent preterm birth.\u2014 Hadi, T., Bardou, M., Mace, G., Sicard, P., Wendremaire, M., Barrichon, M., Richaud, S., Demidov, O., Sagot, P., Garrido, C., Lirussi, F. Glutathione prevents preterm parturition and fetal death by targeting macrophage\u2010induced reactive oxygen species production in the myometrium.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    29, 2653\u20102666 (2015).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.14-266783","type":"journal-article","created":{"date-parts":[[2015,3,10]],"date-time":"2015-03-10T22:52:23Z","timestamp":1426027943000},"page":"2653-2666","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Glutathione prevents preterm parturition and fetal death by targeting macrophage\u2010induced reactive oxygen species production in the myometrium"],"prefix":"10.1096","volume":"29","author":[{"given":"Tarik","family":"Hadi","sequence":"first","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, U866 Lipides Nutrition Cancer Dijon France"},{"name":"Universit\u00e9 de Bourgogne Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Bardou","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, U866 Lipides Nutrition Cancer Dijon France"},{"name":"Universit\u00e9 de Bourgogne Dijon France"},{"name":"Centre Hospitalier Universitaire de Dijon Dijon France"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Centre d'Investigations Cliniques 1432 Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Mace","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire de Dijon Dijon France"},{"name":"Service de Gyn\u00e9cologie &amp; 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