{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T01:09:58Z","timestamp":1774660198611,"version":"3.50.1"},"reference-count":53,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2000,8,1]],"date-time":"2000-08-01T00:00:00Z","timestamp":965088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2000,8]]},"abstract":"<jats:p>\n                    High levels of prostaglandins are produced in human oropharyngeal carcinoma (OPC). Five human OPC cell lines tested expressed both isoforms of cyclooxygenases (COX). The pan\u2010COX inhibitor ketorolac continuously and significantly decreased PGE\n                    <jats:sub>2<\/jats:sub>\n                    production and IL\u20106 and IL\u20108 levels in all OPC cell lines tested, but did not affect IL\u20101a, GM\u2010CSF levels, or\n                    <jats:italic>in vitro<\/jats:italic>\n                    tumor cell growth. In contrast, ketorolac reduced OPC growth\n                    <jats:italic>in vivo.<\/jats:italic>\n                    The OPC cell lines used express the IL\u20106 receptor, and IL\u20106 stimulation of these cells causes transduction to occur via STAT3 pathway activation. Coincubation with OPC cell lines with conditioned medium from a TPA\u2010exposed HL\u201060 cells stimulated growth proportional to the IL\u20106 levels measured in the conditioned medium. This growth effect was specifically inhibited by anti\u2010IL\u20106 antibody. These results are consistent with cytokine products of inflammatory cells having paracrine growth effects on OPC. If chronic inflammation plays a role in promoting the development of OPC, this mechanism may also apply to other epithelial tumor systems modulated by COX activity.\u2013Hong, S. H., Ondrey, F. G., Avis, I. M., Chen, Z., Loukinova, E., Cavanaugh, P. F., Jr., Van Waes, C., Mulshine, J. L. Cyclooxygenase regulates human oropharyngeal carcinomas via the proinflammatory cytokine IL\u20106: a general role for inflammation?.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    14, 1499\u20131507 (2000)\n                  <\/jats:p>","DOI":"10.1096\/fj.99-0802com","type":"journal-article","created":{"date-parts":[[2018,1,18]],"date-time":"2018-01-18T09:16:12Z","timestamp":1516266972000},"page":"1499-1507","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Cyclooxygenase regulates human oropharyngeal carcinomas via the proinflammatory cytokine IL\u20106: a general role for inflammation?"],"prefix":"10.1096","volume":"14","author":[{"given":"Sung H.","family":"Hong","sequence":"first","affiliation":[{"name":"Intervention Section Cell and Cancer Biology Department Medicine Branch Division of Clinical Science National Cancer Institute Bethesda Maryland 20892 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank G.","family":"Ondrey","sequence":"additional","affiliation":[{"name":"Head and Neck Surgery Branch National Institute of Deafness and Other Communication Disorders National Institutes of Health Bethesda Maryland 20892 USA"},{"name":"Department of Otolaryngology University of Minnesota Minneapolis MN 55455 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingalill M.","family":"Avis","sequence":"additional","affiliation":[{"name":"Intervention Section Cell and Cancer Biology Department Medicine Branch Division of Clinical Science National Cancer Institute Bethesda Maryland 20892 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhong","family":"Chen","sequence":"additional","affiliation":[{"name":"Head and Neck Surgery Branch National Institute of Deafness and Other Communication Disorders National Institutes of Health Bethesda Maryland 20892 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Loukinova","sequence":"additional","affiliation":[{"name":"Head and Neck Surgery Branch National Institute of Deafness and Other Communication Disorders National Institutes of Health Bethesda Maryland 20892 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Paul F.","family":"Cavanaugh","sequence":"additional","affiliation":[{"name":"Procter and Gamble Oral Health Care Technology Division Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carter","family":"Van Waes","sequence":"additional","affiliation":[{"name":"Head and Neck Surgery Branch National Institute of Deafness and Other Communication Disorders National Institutes of Health Bethesda Maryland 20892 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James L.","family":"Mulshine","sequence":"additional","affiliation":[{"name":"Intervention Section Cell and Cancer Biology Department Medicine Branch Division of Clinical Science National Cancer Institute Bethesda Maryland 20892 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2000,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1110(83)90019-2"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118480"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.6799"},{"key":"e_1_2_5_5_1","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1182\/blood.V67.6.1675.1675","article-title":"Lipoxygenase metabolites of arachidonic acid modulate hematopoiesis","volume":"67","author":"Snyder D. 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