{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T13:43:09Z","timestamp":1794490989620,"version":"4.9.1"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,7,16]],"date-time":"2015-07-16T00:00:00Z","timestamp":1437004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The vertebrate skeletal system has various functions, including support, movement, protection, and the production of blood cells. The development of cartilage and bones, the core components of the skeletal system, is mediated by systematic inter\u2010 and intracellular communication among multiple signaling pathways in differentiating progenitors and the surrounding tissues. Recently, Pannexin (Panx) 3 has been shown to play important roles in bone development\n                    <jats:italic>in vitro<\/jats:italic>\n                    by mediating multiple signaling pathways, although its roles\n                    <jats:italic>in vivo<\/jats:italic>\n                    have not been explored. In this study, we generated and analyzed\n                    <jats:italic>Panx3<\/jats:italic>\n                    knockout mice and examined the skeletal phenotypes of\n                    <jats:italic>panx3<\/jats:italic>\n                    morphant zebrafish.\n                    <jats:italic>Panx3<\/jats:italic>\n                    <jats:sup>\u2010\/\u2010<\/jats:sup>\n                    embryos exhibited delays in hypertrophic chondrocyte differentiation and osteoblast differentiation as well as the initiation of mineralization, resulting in shortened long bones in adulthood. The abnormal progression of hypertrophic chondrogenesis appeared to be associated with the sustained proliferation of chondrocytes, which resulted from increased intracellular cAMP levels. Similarly, osteoblast differentiation and mineralization were delayed in\n                    <jats:italic>panx3<\/jats:italic>\n                    morphant zebrafish. Taken together, our results provide evidence of the crucial roles of Panx3 in vertebrate skeletal development\n                    <jats:italic>in vivo<\/jats:italic>\n                    .\u2014Oh, S.\u2010K., Shin, J.\u2010O., Baek, J.\u2010I., Lee, J., Bae, J. W., Ankamerddy, H., Kim, M.\u2010J., Huh, T.\u2010L., Ryoo, Z.\u2010Y., Kim, U.\u2010K., Bok, J., Lee, K.\u2010Y. Pannexin 3 is required for normal progression of skeletal development in vertebrates.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    29, 4473\u20104484 (2015).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.15-273722","type":"journal-article","created":{"date-parts":[[2015,7,16]],"date-time":"2015-07-16T22:40:25Z","timestamp":1437086425000},"page":"4473-4484","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Pannexin 3 is required for normal progression of skeletal development in vertebrates"],"prefix":"10.1096","volume":"29","author":[{"given":"Se\u2010Kyung","family":"Oh","sequence":"first","affiliation":[{"name":"Department of Biology College of Natural Sciences Daegu South Korea"},{"name":"School of Life Sciences BrainKorea21 PLUS Project for Kyungpook National University Creative BioResearch Group Daegu South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong\u2010Oh","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Anatomy, BrainKorea21 PLUS Project for Medical Science Yonsei University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong\u2010In","family":"Baek","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinwook","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biology College of Natural Sciences Daegu South Korea"},{"name":"School of Life Sciences BrainKorea21 PLUS Project for Kyungpook National University Creative BioResearch Group Daegu South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Woong","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Anatomy, BrainKorea21 PLUS Project for Medical Science Yonsei University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harinarayana","family":"Ankamerddy","sequence":"additional","affiliation":[{"name":"Department of Anatomy, BrainKorea21 PLUS Project for Medical Science Yonsei University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myoung\u2010Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"School of Life Science and Biotechnology Kyungpook National University Daegu South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae\u2010Lin","family":"Huh","sequence":"additional","affiliation":[{"name":"School of Life Science and Biotechnology Kyungpook National University Daegu South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zae\u2010Young","family":"Ryoo","sequence":"additional","affiliation":[{"name":"School of Life Science and Biotechnology Kyungpook National University Daegu South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Un\u2010Kyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biology College of Natural Sciences Daegu South Korea"},{"name":"School of Life Sciences BrainKorea21 PLUS Project for Kyungpook National University Creative BioResearch Group Daegu South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinwoong","family":"Bok","sequence":"additional","affiliation":[{"name":"Department of Anatomy, BrainKorea21 PLUS Project for Medical Science Yonsei University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu\u2010Yup","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery College of Medicine Kyungpook National University Daegu South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2007.06.009"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.21553"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2008.02.030"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0070-2153(10)90008-2"},{"key":"e_1_2_7_6_1","first-page":"881","article-title":"Divide, accumulate, differentiate: cell condensation in skeletal development revisited","volume":"39","author":"Hall B. 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