{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:11:38Z","timestamp":1791418298811,"version":"4.3.3"},"reference-count":60,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,10,29]],"date-time":"2015-10-29T00:00:00Z","timestamp":1446076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003132","name":"Agentschap voor Innovatie door Wetenschap en Technologie","doi-asserted-by":"publisher","award":["IWT\u2010LO100856"],"award-info":[{"award-number":["IWT\u2010LO100856"]}],"id":[{"id":"10.13039\/501100003132","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:p>\n                    Neonates with intrauterine growth restriction (IUGR) show lower efficiency of nutrient utilization compared to normal birth weight (NBW) newborns. This study was conducted using neonatal piglets as a model to test the hypothesis that IUGR affects the intestinal barrier function, intestinal structure, and antioxidant system development during the suckling period. The small intestinal mucosae were obtained from IUGR and NBW littermates in the suckling period (d 0, 3, 8, and 19 postnatal). The epithelial barrier function was assessed by FITC\u2010dextran 4 (FD4) and horseradish peroxidase (HRP) fluxes across the epithelium, histomorphologic measurements, and expression of tight\u2010junction proteins. Redox status represented by the glutathione disulfide\/glutathione ratio and malondialdehyde concentrations was determined, whereas mRNA expressions of some redox\u2010sensitive proteins were quantified. Results showed that IUGR piglets exhibited a 2\u2010fold higher intestinal permeability in the proximal small intestine on d 0 (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05), and this difference between IUGR and NBW piglets was widened to 3 and 4 times for FD4 and HRP, respectively (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05), on d 3. In accordance, expression of occludin was downregulated at the transcriptional level in IUGR piglets at d 0 and 19 (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.01). Furthermore, the transcription of\n                    <jats:italic>heme oxygenase 1, catalase<\/jats:italic>\n                    , and\n                    <jats:italic>thioredoxin reductase<\/jats:italic>\n                    genes was downregulated in IUGR piglets, mainly on postnatal d 0 and 19 (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.01). It appears that IUGR subjects have a lower capacity to mount an antioxidant response in the early postnatal period. Collectively, these results add to our understanding of the mechanisms responsible for intestinal dysfunction in IUGR neonates.\u2014Wang, W., Degroote, J., Van Ginneken, C., Van Poucke, M., Vergauwen, H., Dam, T. M. T., Vanrompay, D., Peelman, L. J., De Smet, S., Michiels, J. Intrauterine growth restriction in neonatal piglets affects small intestinal mucosal permeability and mRNA expression of redox\u2010sensitive genes.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    30, 863\u2013873 (2016).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.15-274779","type":"journal-article","created":{"date-parts":[[2015,10,30]],"date-time":"2015-10-30T00:19:34Z","timestamp":1446164374000},"page":"863-873","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Intrauterine growth restriction in neonatal piglets affects small intestinal mucosal permeability and mRNA expression of redox\u2010sensitive genes"],"prefix":"10.1096","volume":"30","author":[{"given":"Wei","family":"Wang","sequence":"first","affiliation":[{"name":"Laboratory for Animal Nutrition and Animal Product Quality Department of Animal Production Faculty of Bioscience Engineering Ghent University Melle Belgium"},{"name":"Department of Applied Bioscience Faculty of Bioscience Engineering, and Laboratory of Immunology and Animal Biotechnology Department of Animal Production Faculty of Bioscience Engineering Ghent University Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen","family":"Degroote","sequence":"additional","affiliation":[{"name":"Department of Applied Bioscience Faculty of Bioscience Engineering, and Laboratory of Immunology and Animal Biotechnology Department of Animal Production Faculty of Bioscience Engineering Ghent University Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Van Ginneken","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Veterinary Morphology Department of Veterinary Sciences University of Antwerp Wilrijk Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Van Poucke","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Genetics and Ethology Faculty of Veterinary Medicine Ghent University Merelbeke Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Vergauwen","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Veterinary Morphology Department of Veterinary Sciences University of Antwerp Wilrijk Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi Minh Tho","family":"Dam","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology and Animal Biotechnology Department of Animal Production Faculty of Bioscience Engineering Ghent University Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisy","family":"Vanrompay","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology and Animal Biotechnology Department of Animal Production Faculty of Bioscience Engineering Ghent University Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc J.","family":"Peelman","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Genetics and Ethology Faculty of Veterinary Medicine Ghent University Merelbeke Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefaan","family":"De Smet","sequence":"additional","affiliation":[{"name":"Laboratory for Animal Nutrition and Animal Product Quality Department of Animal Production Faculty of Bioscience Engineering Ghent University Melle Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joris","family":"Michiels","sequence":"additional","affiliation":[{"name":"Department of Applied Bioscience Faculty of Bioscience Engineering, and Laboratory of Immunology and Animal Biotechnology Department of Animal Production Faculty of Bioscience Engineering Ghent University Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2006-156"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.livsci.2010.06.015","article-title":"Intrauterine growth restriction reduces intestinal structure and modifies the response to colostrum in preterm and term piglets","volume":"133","author":"D'Inca R.","year":"2010","journal-title":"Livest. 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