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Mitochondrial content and function are enhanced by endurance exercise and impaired in states or diseases where muscle function is compromised, such as myopathies, muscular dystrophies, neuromuscular diseases, and age\u2010related muscle atrophy. Hence, elucidating the mechanisms that control muscle mitochondrial content and oxidative function can provide new insights into states and diseases that affect muscle health. In past studies, we identified\n                    <jats:italic>Perm1<\/jats:italic>\n                    (PPARGC1\u2010 and ESRR\u2010induced regulator, muscle 1) as a gene induced by endurance exercise in skeletal muscle, and regulating mitochondrial oxidative function in cultured myotubes. The capacity of Perm1 to regulate muscle mitochondrial content and function\n                    <jats:italic>in vivo<\/jats:italic>\n                    is not yet known. In this study, we use adeno\u2010associated viral (AAV) vectors to increase Perm1 expression in skeletal muscles of 4\u2010wk\u2010old mice. Compared to control vector, AAV1\u2010Perm1 leads to significant increases in mitochondrial content and oxidative capacity (by 40\u201080%). Moreover, AAV1\u2010Perm1\u2010transduced muscles show increased capillary density and resistance to fatigue (by 33 and 31\n                    <jats:italic>%<\/jats:italic>\n                    , respectively), without prominent changes in fiber\u2010type composition. These findings suggest that Perm1 selectively regulates mitochondrial biogenesis and oxidative function, and implicate Perm1 in muscle adaptations that also occur in response to endurance exercise.\u2014Cho, Y., Hazen, B. C., Gandra, P. G., Ward, S. R., Schenk, S., Russell, A. P., Kralli, A. Perm1 enhances mitochondrial biogenesis, oxidative capacity, and fatigue resistance in adult skeletal muscle.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    30, 674\u2010687 (2016).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.15-276360","type":"journal-article","created":{"date-parts":[[2015,10,20]],"date-time":"2015-10-20T00:37:20Z","timestamp":1445301440000},"page":"674-687","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Perm1 enhances mitochondrial biogenesis, oxidative capacity, and fatigue resistance in adult skeletal muscle"],"prefix":"10.1096","volume":"30","author":[{"given":"Yoshitake","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Chemical Physiology The Scripps Research Institute La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bethany C.","family":"Hazen","sequence":"additional","affiliation":[{"name":"Department of Chemical Physiology The Scripps Research Institute La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo G.","family":"Gandra","sequence":"additional","affiliation":[{"name":"Department of Chemical Physiology The Scripps Research Institute La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel R.","family":"Ward","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery School of Medicine University of California, San Diego La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Schenk","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery School of Medicine University of California, San Diego La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron P.","family":"Russell","sequence":"additional","affiliation":[{"name":"Centre for Physical Activity and Nutrition Research School of Exercise and Nutrition Sciences Deakin University Burwood Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Kralli","sequence":"additional","affiliation":[{"name":"Department of Chemical Physiology The Scripps Research Institute La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.10.029"},{"key":"e_1_2_7_3_1","first-page":"11","article-title":"Human aging, muscle mass, and fiber type composition","volume":"50","author":"Lexell J.","year":"1995","journal-title":"J. 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