{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T15:28:49Z","timestamp":1774020529156,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,11,18]],"date-time":"2015-11-18T00:00:00Z","timestamp":1447804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01 AI043197"],"award-info":[{"award-number":["R01 AI043197"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:p>\n                    <jats:italic>Leishmania donovani<\/jats:italic>\n                    is an intracellular parasite that infects professional phagocytes and causes visceral leishmaniasis (VL). The immune response during VL has been extensively studied in the context of T\u2010helper (T\n                    <jats:sub>h<\/jats:sub>\n                    ) 1 and T\n                    <jats:sub>h<\/jats:sub>\n                    2 responses. Immunity against this parasite is dependent on IFN\u2010\u03b3 production and subsequent macrophage activation, and the T\n                    <jats:sub>h<\/jats:sub>\n                    2 response promotes granuloma formation. The cytokine IL\u201017A is associated with neutrophilic inflammation. Depletion of neutrophils during experimental VL results in enhanced parasitic loads. Furthermore, although patients resistant to VL showed enhanced levels of IL\u201017A in circulation, little is known about the role of IL\u201017A during VL infection. Here, we used IL\u201017A\u2010deficient mice and IL\u201017A reporter mice to address the role of IL\u201017A during VL. IL\u201017A\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    mice were highly resistant to VL infection, showing decreased parasites in the liver and spleen. This unexpected phenotype was associated with enhanced IFN\u2010\u03b3 production by T cells and decreased accumulation of neutrophils and monocytes, resulting in reduced number of granulomas. We also found \u03b3\u03b4 T and T\n                    <jats:sub>h<\/jats:sub>\n                    17 cells as the main IL\u201017A\n                    <jats:sup>+<\/jats:sup>\n                    cells during VL infection. Our data reveal an unexpected role of IL\u201017A rendering susceptibility against\n                    <jats:italic>L. donovani<\/jats:italic>\n                    by regulating the IFN\u2010\u03b3 response and promoting detrimental inflammation.\u2014Terrazas, C., Varikuti, S., Kimble, J., Moretti, E., Boyaka, P. N., Satoskar, A. R., IL\u201017A promotes susceptibility during experimental visceral leishmaniasis caused by\n                    <jats:italic>Leishmania donovani<\/jats:italic>\n                    . FASEB J. 30, 1135\u20101143 (2016).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.15-277202","type":"journal-article","created":{"date-parts":[[2015,11,18]],"date-time":"2015-11-18T22:34:11Z","timestamp":1447886051000},"page":"1135-1143","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["IL\u201017A promotes susceptibility during experimental visceral leishmaniasis caused by\n                    <i>Leishmania donovani<\/i>"],"prefix":"10.1096","volume":"30","author":[{"given":"Cesar","family":"Terrazas","sequence":"first","affiliation":[{"name":"Department of Pathology The Ohio State University Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjay","family":"Varikuti","sequence":"additional","affiliation":[{"name":"Department of Pathology The Ohio State University Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Kimble","sequence":"additional","affiliation":[{"name":"Department of Pathology The Ohio State University Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen","family":"Moretti","sequence":"additional","affiliation":[{"name":"Department of Pathology The Ohio State University Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prosper N.","family":"Boyaka","sequence":"additional","affiliation":[{"name":"Department of Veterinary Biosciences The Ohio State University Columbus Ohio USA"},{"name":"Department of Internal Medicine The Ohio State University Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhay R.","family":"Satoskar","sequence":"additional","affiliation":[{"name":"Department of Pathology The Ohio State University Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,11,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hct116"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.189.4.741"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201343477"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M305030200"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3024.1999.00240.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.1.22"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20040704"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.3.1458"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir080"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.8.4804-4807.2003"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2008.01.011"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2005.01.009"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2013.07.022"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.1.566"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.08.025"},{"key":"e_1_2_7_17_1","doi-asserted-by":"crossref","first-page":"el004099","DOI":"10.1371\/journal.ppat.1004099","article-title":"Unexpected role for IL\u201017 in protective immunity against hypervirulent Mycobacterium tuberculosis HN878 infection","volume":"10","author":"Gopal R.","year":"2014","journal-title":"PLoS Pathog."},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI40891"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1086\/422329"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0713598"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003243"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01388-07"},{"key":"e_1_2_7_23_1","first-page":"2379","article-title":"IL\u201017 and IL\u201022 are associated with protection against human kala azar caused by Leishmania donovani","volume":"119","author":"Pitta M. 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