{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T22:22:12Z","timestamp":1792448532505,"version":"4.5.0"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,11,17]],"date-time":"2015-11-17T00:00:00Z","timestamp":1447718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007434","name":"Suzuken Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007434","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:p>\n                    Obesity is associated with an increased risk of cardiovascular disease. C1q\/TNF\u2010related protein (CTRP)\u20101 is a poorly characterized adipokine that is up\u2010regulated in association with ischemic heart disease. We investigated the role of CTRP1 in myocardial ischemia injury. CTRP1\u2010knockout mice showed increased myocardial infarct size, cardiomyocyte apoptosis, and proinflammatory gene expression after I\/R compared with wild\u2010type (WT) mice. In contrast, systemic delivery of CTRP1 attenuated myocardial damage after I\/R in WT mice. Treatment of cardiomyocytes with CTRP1 led to reduction of hypoxia\u2010reoxygenation\u2010induced apoptosis and lipopolysaccharide\u2010stimulated expression of proinflammatory cytokines, which was reversed by inhibition of sphingosine\u20101\u2010phosphate (S1P) signaling. Treatment of cardiomyocytes with CTRP1 also resulted in the increased production of cAMP, which was blocked by suppression of S1P signaling. The antiapoptotic and anti\u2010inflammatory actions of CTRP1 were cancelled by inhibition of adenylyl cyclase or knockdown of adiponectin receptor 1. Furthermore, blockade of S1P signaling reversed CTRP1\u2010mediated inhibition of myocardial infarct size, apoptosis, and inflammation after I\/R\n                    <jats:italic>in vivo.<\/jats:italic>\n                    These data indicate that CTRP1 protects against myocardial ischemic injury by reducing apoptosis and inflammatory response through activation of the S1P\/cAMP signaling pathways in cardiomyocytes, suggesting that CTRP1 plays a crucial role in the pathogenesis of ischemic heart disease.\u2014Yuasa, D., Ohashi, K., Shibata, R., Mizutani, N., Kataoka, Y., Kambara, T., Uemura, Y., Matsuo, K., Kanemura, N., Hayakawa, S., Hiramatsu\u2010Ito, M., Ito, M., Ogawa, H., Murate, T., Murohara, T., Ouchi, N., C1q\/TNF\u2010related protein\u20101 functions to protect against acute ischemic injury in the heart. 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