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We have previously demonstrated that occupancy of A2A receptor (A\n                    <jats:sub>2A<\/jats:sub>\n                    R) stimulates collagen production, so we determined whether blockade or deletion of A\n                    <jats:sub>2A<\/jats:sub>\n                    R could prevent radiation\u2010induced fibrosis. After targeted irradiation (40 Gy) of the skin of wild\u2010type (WT) or A\n                    <jats:sub>2A<\/jats:sub>\n                    R knockout (A2ARKO) mice, the A\n                    <jats:sub>2A<\/jats:sub>\n                    R antagonist ZM241385 was applied daily for 28 d. In irradiated WT mice treated with the A\n                    <jats:sub>2A<\/jats:sub>\n                    R antagonist, there was a marked reduction in collagen content and skin thickness, and ZM241385 treatment reduced the number of myofibroblasts and angiogenesis. After irradiation, there is an increase in loosely packed collagen fibrils, which is significantly diminished by ZM241385. Irradiation also induced an increase in epidermal thickness, prevented by ZM241385, by increasing the number of proliferating keratinocytes. Similarly, in A2ARKO mice, the changes in collagen alignment, skin thickness, myofibroblast content, angiogenesis, and epidermal hyperplasia were markedly reduced following irradiation. Radiation\u2010induced changes in the dermis and epidermis were accompanied by an infiltrate of T cells, which was prevented in both ZM241385\u2010treated and A2ARKO mice. Radiation therapy is administered to a significant number of patients with cancer, and radiation reactions may limit this therapeutic modality. Our findings suggest that topical application of an A\n                    <jats:sub>2A<\/jats:sub>\n                    R antagonist prevents radiation dermatitis and may be useful in the prevention or amelioration of radiation changes in the skin.\u2014Perez\u2010Aso, M., Mediero, A., Low, Y. C., Levine, J., Cronstein, B. N. Adenosine A2A receptor plays an important role in radiation\u2010induced dermal injury.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    30, 457\u2010465 (2016).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.15-280388","type":"journal-article","created":{"date-parts":[[2015,9,28]],"date-time":"2015-09-28T22:48:01Z","timestamp":1443480481000},"page":"457-465","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Adenosine A2A receptor plays an important role in radiation\u2010induced dermal injury"],"prefix":"10.1096","volume":"30","author":[{"given":"Miguel","family":"Perez\u2010Aso","sequence":"first","affiliation":[{"name":"Division of Translational Medicine, Department of Medicine New York University School of Medicine New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ar\u00e1nzazu","family":"Mediero","sequence":"additional","affiliation":[{"name":"Division of Translational Medicine, Department of Medicine New York University School of Medicine New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yee Cheng","family":"Low","sequence":"additional","affiliation":[{"name":"New York University Cancer Center, New York University School of Medicine New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamie","family":"Levine","sequence":"additional","affiliation":[{"name":"New York University Cancer Center, New York University School of Medicine New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce N.","family":"Cronstein","sequence":"additional","affiliation":[{"name":"Division of Translational Medicine, Department of Medicine New York University School of Medicine New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,9,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.360"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-8140(89)90095-9"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(94)00429-O"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/09553009014550911"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.411"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(96)01838-5"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(97)00716-5"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3747\/co.v17i4.493"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soncn.2011.02.009"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4801.2005.00079.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-8140(95)01540-W"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2010.107"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0885-3924(91)90015-V"},{"key":"e_1_2_7_15_1","first-page":"1601","article-title":"Exaggerated fibrosis in patients with systemic sclerosis (scleroderma) following radiation therapy","volume":"20","author":"Abu\u2010Shakra M.","year":"1993","journal-title":"J. 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