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However, the physiologic function of Crym in skeletal muscle remains to be elucidated. In this study, Crym was preferentially expressed in skeletal muscle throughout the body.\n                    <jats:italic>Crym<\/jats:italic>\n                    \u2010knockout mice exhibited a significant hypertrophy of fast\u2010twitch glycolytic type IIb fibers, causing an increase in grip strength and high intensity running ability in\n                    <jats:italic>Crym<\/jats:italic>\n                    \u2010null mice. Genetic inactivation of\n                    <jats:italic>Crym<\/jats:italic>\n                    or blockade of\n                    <jats:italic>Crym<\/jats:italic>\n                    by siRNA\u2010mediated knockdown up\u2010regulated the gene expression of fast\u2010glycolytic contractile fibers in satellite cell\u2010derived myotubes\n                    <jats:italic>in vitro.<\/jats:italic>\n                    These alterations in\n                    <jats:italic>Crym<\/jats:italic>\n                    \u2010inactivated muscle were rescued by inhibition of thyroid hormone, even though Crym is a positive regulator of thyroid hormone action in nonmuscle cells. The results demonstrated that Crym is a crucial regulator of muscle plasticity, controlling metabolic and contractile properties of myofibers, and thus the selective inactivation of Crym may be a potential therapeutic target for muscle\u2010wasting diseases, such as muscular dystrophies and age\u2010related sarcopenia.\u2014Seko, D., Ogawa, S., Li, T.\u2010S., Taimura, A., Ono, Y. \u03bc\u2010Crystallin controls muscle function through thyroid hormone action.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    30, 1733\u20131740 (2016).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.15-280933","type":"journal-article","created":{"date-parts":[[2015,12,30]],"date-time":"2015-12-30T22:33:23Z","timestamp":1451514803000},"page":"1733-1740","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["\u03bc\u2010Crystallin controls muscle function through thyroid hormone action"],"prefix":"10.1096","volume":"30","author":[{"given":"Daiki","family":"Seko","sequence":"first","affiliation":[{"name":"Department of Stem Cell Biology Atomic Bomb Disease Institute Nagasaki University Graduate School of Biomedical Sciences Graduate School of Fisheries and Environmental Sciences Nagasaki Japan"},{"name":"Institute of Environmental Science Graduate School of Fisheries and Environmental Sciences Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shizuka","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Biology Atomic Bomb Disease Institute Nagasaki University Graduate School of Biomedical Sciences Graduate School of Fisheries and Environmental Sciences Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao\u2010Sheng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Biology Atomic Bomb Disease Institute Nagasaki University Graduate School of Biomedical Sciences Graduate School of Fisheries and Environmental Sciences Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Taimura","sequence":"additional","affiliation":[{"name":"Institute of Environmental Science Graduate School of Fisheries and Environmental Sciences Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Biology Atomic Bomb Disease Institute Nagasaki University Graduate School of Biomedical Sciences Graduate School of Fisheries and Environmental Sciences Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4467"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/10409238.2013.857291"},{"key":"e_1_2_8_4_1","first-page":"1046","article-title":"Thyroid hormone signaling in muscle development, repair and metabolism","volume":"2","author":"Lee J. 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