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In this study, we first demonstrated that invading\n                    <jats:italic>A. baumannii<\/jats:italic>\n                    induced a complete, ubiquitin\u2010mediated autophagic response that is dependent upon septins SEPT2 and SEPT9 in mammalian cells. We also demonstrated that autophagy induced by\n                    <jats:italic>A. baumannii<\/jats:italic>\n                    was Beclin\u20101 dependent\n                    <jats:italic>via<\/jats:italic>\n                    the AMPK\/ERK\/mammalian target of rapamycin pathway. Of interest, we found that the isochorismatase mutant strain had significantly decreased siderophore\u2010mediated ferric iron acquisition ability and had a reduced the ability to induce autophagy. We verified that isochorismatase was required for the recognition of intracytosolic\n                    <jats:italic>A. baumannii<\/jats:italic>\n                    mediated by septin cages, ubiquitinated proteins, and ubiquitin\u2010binding adaptor proteins p62 and NDP52 in autophagic response. We also confirmed that isochorismatase was required for the clearance of invading\n                    <jats:italic>A. baumannii<\/jats:italic>\n                    by autophagy\n                    <jats:italic>in vitro<\/jats:italic>\n                    and in the mouse model of infection. Together, these findings provide insight into the distinctive recognition and clearance of intracytosolic\n                    <jats:italic>A. baumannii<\/jats:italic>\n                    by autophagy in host cells, and that isochorismatase plays a critical role in the A. baumannii\u2013induced autophagic process.\u2014Wang, Y., Zhang, K., Shi, X., Wang, C., Wang, F., Fan, J., Shen, F., Xu, J., Bao, W., Liu, M., Yu, L. Critical role of bacterial isochorismatase in the autophagic process induced by\n                    <jats:italic>Acinetobacter baumannii<\/jats:italic>\n                    in mammalian cells. FASEB J. 30, 3563\u20133577 (2016).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201500019r","type":"journal-article","created":{"date-parts":[[2016,7,18]],"date-time":"2016-07-18T23:09:20Z","timestamp":1468883360000},"page":"3563-3577","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Critical role of bacterial isochorismatase in the autophagic process induced by\n                    <i>Acinetobacter baumannii<\/i>\n                    in mammalian cells"],"prefix":"10.1096","volume":"30","author":[{"given":"Yang","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases First Hospital of Jilin University Key Laboratory for Zoonosis Research Institute of Zoonosis Jilin University Ministry of Medical Sciences  Changchun 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