{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T20:17:21Z","timestamp":1793305041203,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,3,8]],"date-time":"2016-03-08T00:00:00Z","timestamp":1457395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL89934"],"award-info":[{"award-number":["HL89934"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL126913\u201301"],"award-info":[{"award-number":["R01HL126913\u201301"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001734","name":"K\u00f8benhavns Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001734","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Apolipoprotein M (ApoM) transports sphingosine\u20101\u2010phosphate (S1P) in plasma, and ApoM\u2010deficient mice (\n                    <jats:italic>\n                      Apom\n                      <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    <\/jats:italic>\n                    ) have ~50% reduced plasma S1P levels. There are 5 known S1P receptors, and S1P induces adherens junction formation between endothelial cells through the S1P1 receptor, which in turn suppresses vascular leak. Increased vascular permeability is a hallmark of inflammation. The purpose of this study was to explore the relationships between vascular leakage in ApoM deficiency and S1P1 function in normal physiology and in inflammation. Vascular permeability in the lungs was assessed by accumulation of dextran molecules (70 kDa) and was increased ~40% in\n                    <jats:italic>\n                      Apom\n                      <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    <\/jats:italic>\n                    mice compared to WT (C57Bl6\/j) mice. Reconstitution of plasma ApoM\/S1P or treatment with an S1P1 receptor agonist (SEW2871) rapidly reversed the vascular leakage to a level similar to that in WT mice, suggesting that it is caused by decreased plasma levels of S1P and reduced S1P1 stimulation. In a carrageenan\u2010induced model of inflammation,\n                    <jats:italic>\n                      Apom\n                      <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    <\/jats:italic>\n                    mice had increased vascular leakage compared with that in WT mice. Adenoviral overexpression of ApoM in\n                    <jats:italic>\n                      Apom\n                      <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    <\/jats:italic>\n                    mice decreased the vascular leakage compared to adenoviral overexpression of green fluorescent protein. The study suggests that vascular leakage of albumin\u2010sized particles in ApoM deficiency is S1P\u2010 and S1P\n                    <jats:sub>1<\/jats:sub>\n                    \u2010dependent and this dependency exacerbates the response to inflammatory stimuli.\u2014Christensen, P. M., Liu, C. H., Swendeman, S. L., Obinata, H., Qvortrup, K., Nielsen, L B., Hla, T., Di Lorenzo, A., Christoffersen, C. Impaired endothelial barrier function in apolipoprotein M\u2010deficient mice is dependent on sphingosine\u20101\u2010phosphate receptor 1. FASEB J. 30, 2351\u20132359 (2016).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201500064","type":"journal-article","created":{"date-parts":[[2016,3,8]],"date-time":"2016-03-08T23:44:15Z","timestamp":1457480655000},"page":"2351-2359","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":116,"title":["Impaired endothelial barrier function in apolipoprotein M\u2010deficient mice is dependent on sphingosine\u20101\u2010phosphate receptor 1"],"prefix":"10.1096","volume":"30","author":[{"given":"Pernille M.","family":"Christensen","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry Rigshospitalet Copenhagen Denmark"},{"name":"Department of Biomedical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine H.","family":"Liu","sequence":"additional","affiliation":[{"name":"Center for Vascular Biology Department of Pathology and Laboratory Medicine Weill Cornell Medical College Cornell University New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven L.","family":"Swendeman","sequence":"additional","affiliation":[{"name":"Center for Vascular Biology Department of Pathology and Laboratory Medicine Weill Cornell Medical College Cornell University New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideru","family":"Obinata","sequence":"additional","affiliation":[{"name":"Center for Vascular Biology Department of Pathology and Laboratory Medicine Weill Cornell Medical College Cornell University New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Qvortrup","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars B.","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Rigshospitalet Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Hla","sequence":"additional","affiliation":[{"name":"Center for Vascular Biology Department of Pathology and Laboratory Medicine Weill Cornell Medical College Cornell University New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annarita","family":"Di Lorenzo","sequence":"additional","affiliation":[{"name":"Center for Vascular Biology Department of Pathology and Laboratory Medicine Weill Cornell Medical College Cornell University New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Christoffersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Rigshospitalet Copenhagen Denmark"},{"name":"Department of Biomedical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2009.08.071"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M700103-JLR200"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1103187108"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14462"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-1981(02)00139-7"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3520809"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.107.143735"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81661-X"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI31123"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3934"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI12450"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH12-09-0678"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07201"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2010-0422OC"},{"key":"e_1_2_7_16_1","first-page":"1871","article-title":"Sphingosine\u20101\u2010phosphate in the plasma compartment regulates basal and inflammation\u2010induced vascular leak in mice","volume":"119","author":"Camerer E.","year":"2009","journal-title":"J. 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