{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T17:57:12Z","timestamp":1793901432387,"version":"4.8.0"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,6,16]],"date-time":"2016-06-16T00:00:00Z","timestamp":1466035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01-HD076422"],"award-info":[{"award-number":["R01-HD076422"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R01-ES010610"],"award-info":[{"award-number":["R01-ES010610"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Bisphenol\u2010A (BPA) is an environmentally ubiquitous estrogen\u2010like endocrine\u2010disrupting compound. Exposure to BPA\n                    <jats:italic>in utero<\/jats:italic>\n                    has been linked to female reproductive disorders, including endometrial hyperplasia and breast cancer. Estrogens are an etiological factor in many of these conditions. We sought to determine whether\n                    <jats:italic>in utero<\/jats:italic>\n                    exposure to BPA altered the global CpG methylation pattern of the uterine genome, subsequent gene expression, and estrogen response. Pregnant mice were exposed to an environmentally relevant dose of BPA or DMSO control. Uterine DNA and RNA were examined by using methylated DNA immunoprecipitation methylation microarray, expression microarray, and quantitative PCR.\n                    <jats:italic>In utero<\/jats:italic>\n                    BPA exposure altered the global CpG methylation profile of the uterine genome and subsequent gene expression. The effect on gene expression was not apparent until sexual maturation, which suggested that estrogen response was the primary alteration. Indeed, prenatal BPA exposure preferentially altered adult estrogen\u2010responsive gene expression. Changes in estrogen response were accompanied by altered methylation that preferentially affected estrogen receptor\u2010a (ERa)\u2013binding genes. The majority of genes that demonstrated both altered expression and ERa binding had decreased methylation. BPA selectively altered the normal developmental programming of estrogen\u2010responsive genes\n                    <jats:italic>via<\/jats:italic>\n                    modification of the genes that bind ERa. Gene\u2013 environment interactions driven by early life xenoestrogen exposure likely contributes to increased risk of estrogenrelated disease in adults.\u2014Jorgensen, E. M., Alderman, M.H., III, Taylor, H. S. Preferential epigenetic programming of estrogen response after\n                    <jats:italic>in utero<\/jats:italic>\n                    xenoestrogen (bisphenol\u2010A) exposure. FASEB J. 30, 3194\u20133201 (2016).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201500089r","type":"journal-article","created":{"date-parts":[[2016,6,16]],"date-time":"2016-06-16T23:11:22Z","timestamp":1466118682000},"page":"3194-3201","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Preferential epigenetic programming of estrogen response after\n                    <i>in utero<\/i>\n                    xenoestrogen (bisphenol\u2010A) exposure"],"prefix":"10.1096","volume":"30","author":[{"given":"Elisa M.","family":"Jorgensen","sequence":"first","affiliation":[{"name":"Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Myles H.","family":"Alderman","sequence":"additional","affiliation":[{"name":"Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugh S.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.08.067"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.09-140533"},{"issue":"2","key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"e57","DOI":"10.1016\/j.fertnstert.2007.12.030","article-title":"Endocrine disruptors affect developmental programming of HOX gene expression","volume":"89","author":"Taylor H. 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