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Because specialized proresolving lipid mediators (SPMs; lipoxins, resolvins, and protectins) stimulate resolution of inflammation in animal models, we tested whether n\u20103 fatty acids impact SPM profiles in patients with CAD and promote clot remodeling. Six patients with stable CAD were randomly assigned to either treatment with daily 3.36 g Lovaza for 1 yr or without. Targeted lipid mediator\u2010metabololipidomics showed that both groups had absence of resolvin D1 (RvD1), RvD2, RvD3, RvD5 and resolvin E1\u2014all of which are present in healthy patients. Those not taking Lovaza had an absence of aspirin\u2010triggered resolvin D3 (AT\u2010RvD3) and aspirin\u2010triggered lipoxin B\n                    <jats:sub>4<\/jats:sub>\n                    (AT\u2010LXB\n                    <jats:sub>4<\/jats:sub>\n                    ). Lovaza treatment restored AT\u2010RvD3 and AT\u2010LXB\n                    <jats:sub>4<\/jats:sub>\n                    and gave levels of RvD6 and aspirin\u2010triggered protectin D1 (AT\u2010PD1) twice as high (resolvin E2 ~5 fold) as well as lower prostaglandins. Principal component analysis indicated positive relationships for patients with CAD who were receiving Lovaza with increased AT\u2010RvD3, RvD6, AT\u2010PD1, and AT\u2010LXB4.SPMs identified in Lovaza\u2010treated patients with CAD enhanced ~50% at 1 nM macrophage uptake of blood clots. These results indicate that patients with CAD have lower levels and\/or absence of specific SPMs that were restored with Lovaza; these SPMs promote macrophage phagocytosis of blood clots. Together, they suggest that low vascular SPMs may enable progression of chronic vascular inflammation predisposing to coronary atherosclerosis and to thrombosis.\u2014Elajami, T. K., Colas, R. A., Dalli, J., Chiang, N., Serhan, C. N., Welty, F. K. Specialized proresolving lipid mediators in patients with coronary artery disease and their potential for clot remodeling. FASEB J. 30, 2792\u20102801 (2016).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201500155r","type":"journal-article","created":{"date-parts":[[2016,4,28]],"date-time":"2016-04-28T12:42:59Z","timestamp":1461847379000},"page":"2792-2801","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":131,"title":["Specialized proresolving lipid mediators in patients with coronary artery disease and their potential for clot remodeling"],"prefix":"10.1096","volume":"30","author":[{"given":"Tarec K.","family":"Elajami","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine Department of Internal Medicine Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine Brigham and Women's Hospital Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain A.","family":"Colas","sequence":"additional","affiliation":[{"name":"Center for Experimental Therapeutics and Reperfusion Injury Department of Anesthesiology, Perioperative and Pain Medicine Harvard Institutes of Medicine Brigham and Women's Hospital Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesmond","family":"Dalli","sequence":"additional","affiliation":[{"name":"Center for Experimental Therapeutics and Reperfusion Injury Department of Anesthesiology, Perioperative and Pain Medicine Harvard Institutes of Medicine Brigham and Women's Hospital Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Chiang","sequence":"additional","affiliation":[{"name":"Center for Experimental Therapeutics and Reperfusion Injury Department of Anesthesiology, Perioperative and Pain Medicine Harvard Institutes of Medicine Brigham and Women's Hospital Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles N.","family":"Serhan","sequence":"additional","affiliation":[{"name":"Center for Experimental Therapeutics and Reperfusion Injury Department of Anesthesiology, Perioperative and Pain Medicine Harvard Institutes of Medicine Brigham and Women's Hospital Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francine K.","family":"Welty","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Department of Internal Medicine Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine Brigham and Women's Hospital Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,27]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"World Health Organization. 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