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Although SERPINE2 is a candidate susceptibility gene for chronic obstructive pulmonary disease, the physiologic role of this protease inhibitor in lung development and homeostasis is unknown. We observed spontaneous monocytic\u2010cell infiltration in the lungs of Serpine2\u2010deficient (SE2\n                    <jats:sup>\u2010\/\u2010<\/jats:sup>\n                    ) mice, beginning at or before the time of lung maturity, which resulted in lesions that resembled bronchus\u2010associated lymphoid tissue (BALT). The initiation of lymphocyte accumulation in the lungs of SE2\n                    <jats:sup>\u2010\/\u2010<\/jats:sup>\n                    mice involved the excessive expression of chemokines, cytokines, and adhesion molecules that are essential for BALT induction, organization, and maintenance. BALT\u2010like lesion formation in the lungs of SE2\n                    <jats:sup>\u2010\/\u2010<\/jats:sup>\n                    mice was also associated with a significant increase in the activation of thrombin, a recognized target of SE2, and excess stimulation of NF\u2010\u03baB, a major regulator of chemokine expression and inflammation. Finally, systemic delivery of thrombin rapidly stimulated lung chemokine expression\n                    <jats:italic>in vivo.<\/jats:italic>\n                    These data uncover a novel mechanism whereby loss of serine protease inhibition leads to lung lymphocyte accumulation.\u2014Solleti, S. K., Srisuma, S., Bhattacharya, S., Rangel\u2010Moreno, J., Bijli, K. M., Randall, T. D., Rahman, A., Mariani, T. J. Serpine2 deficiency results in lung lymphocyte accumulation and bronchus\u2010associated lymphoid tissue formation. FASEB J. 30, 2615\u20102626 (2016).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201500159r","type":"journal-article","created":{"date-parts":[[2016,4,9]],"date-time":"2016-04-09T00:07:07Z","timestamp":1460160427000},"page":"2615-2626","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Serpine2 deficiency results in lung lymphocyte accumulation and bronchus\u2010associated lymphoid tissue formation"],"prefix":"10.1096","volume":"30","author":[{"given":"Siva Kumar","family":"Solleti","sequence":"first","affiliation":[{"name":"Division of Neonatology Department of Pediatrics University of Rochester Medical Center Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sorachai","family":"Srisuma","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumyaroop","family":"Bhattacharya","sequence":"additional","affiliation":[{"name":"Division of Neonatology Department of Pediatrics University of Rochester Medical Center Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Rangel\u2010Moreno","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology, and Rheumatology University of Rochester Medical Center Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiser M.","family":"Bijli","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy, and Critical Care Medicine Emory University\/Atlanta Veterans Affairs Medical Center Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Troy D.","family":"Randall","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology, and Rheumatology University of Rochester Medical Center Rochester New York USA"},{"name":"Division of Clinical Immunology and Rheumatology Department of Medicine University of Alabama at Birmingham Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arshad","family":"Rahman","sequence":"additional","affiliation":[{"name":"Division of Neonatology Department of Pediatrics University of Rochester Medical Center Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Mariani","sequence":"additional","affiliation":[{"name":"Division of Neonatology Department of Pediatrics University of Rochester Medical Center Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/rr34"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.56.062904.144908"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/499828"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0904006"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/15412555.2010.496821"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1378\/chest.08-1993","article-title":"Genetic associations with hypoxemia and pulmonary arterial pressure in COPD","volume":"135","author":"Castaldi P. 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