{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T07:46:00Z","timestamp":1773215160242,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,3,15]],"date-time":"2016-03-15T00:00:00Z","timestamp":1458000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chronic obstructive pulmonary disease (COPD) is complicated by infectious exacerbations with acute worsening of respiratory symptoms. Coinfections of bacterial and viral pathogens are associated with more severe exacerbations.\n                    <jats:italic>Moraxella catarrhalis<\/jats:italic>\n                    is one of the most frequent lower respiratory tract pathogens detected in COPD. We therefore studied the impact of\n                    <jats:italic>M. catarrhalis<\/jats:italic>\n                    on the antiviral innate immune response that is mediated\n                    <jats:italic>via<\/jats:italic>\n                    TLR3 and p53. Molecular interactions between\n                    <jats:italic>M. catarrhalis<\/jats:italic>\n                    and normal human bronchial epithelial (NHBE) cells as well as Beas\u20102B cells were studied using flow cytometry, quantitative PCR analysis, chromatin immunoprecipitation, RNA interference, and ELISA.\n                    <jats:italic>M. catarrhalis<\/jats:italic>\n                    induces a significant down\u2010regulation of TLR3 in human bronchial epithelial cells. In\n                    <jats:italic>M. catarrhalis<\/jats:italic>\n                    \u2010infected cells, expression of p53 was decreased. We detected a reduced binding of p53 to the\n                    <jats:italic>tlr3<\/jats:italic>\n                    promoter, resulting in reduced TLR3 gene transcription.\n                    <jats:italic>M. catarrhalis<\/jats:italic>\n                    diminished the TLR3\u2010dependent secretion of IFN\u2010\u03b2, IFN\u2010\u03bb, and chemokine (C\u2010X\u2010C motif) ligand 8. In addition in\n                    <jats:italic>M. catarrhalis infected cells<\/jats:italic>\n                    , expression of rhinovirus type 1A RNA was increased compared with uninfected cells.\n                    <jats:italic>M. catarrhalis<\/jats:italic>\n                    reduces antiviral defense functions of bronchial epithelial cells, which may increase susceptibility to viral infections.\u2014Heinrich, A., Haarmann, H., Zahradnik, S., Frenzel, K., Schreiber, F., Klassert, T. E., Heyl, K. A., Endres, A.\u2010S., Schmidtke, M., Hofmann, J., Slevogt, H.\n                    <jats:italic>Moraxella catarrhalis<\/jats:italic>\n                    decreases antiviral innate immune responses by down\u2010regulation of TLR3\n                    <jats:italic>via<\/jats:italic>\n                    inhibition of p53 in human bronchial epithelial cells. FASEB J. 30, 2426\u20132434 (2016).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201500172r","type":"journal-article","created":{"date-parts":[[2016,3,15]],"date-time":"2016-03-15T23:54:13Z","timestamp":1458086053000},"page":"2426-2434","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["<i>Moraxella catarrhalis<\/i>\n                    decreases antiviral innate immune responses by down\u2010regulation of TLR3\n                    <i>via<\/i>\n                    inhibition of p53 in human bronchial epithelial cells"],"prefix":"10.1096","volume":"30","author":[{"given":"Annina","family":"Heinrich","sequence":"first","affiliation":[{"name":"Septomics Research Center School of Medicine Jena University Hospital Jena Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helge","family":"Haarmann","sequence":"additional","affiliation":[{"name":"Clinic for Cardiology and Pneumology University Medical Center G\u00f6ttingen G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina","family":"Zahradnik","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Hygiene, Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrin","family":"Frenzel","sequence":"additional","affiliation":[{"name":"Institute of Medical Virology, Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frauke","family":"Schreiber","sequence":"additional","affiliation":[{"name":"Septomics Research Center School of Medicine Jena University Hospital Jena Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tilman E.","family":"Klassert","sequence":"additional","affiliation":[{"name":"Septomics Research Center School of Medicine Jena University Hospital Jena Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerstin A.","family":"Heyl","sequence":"additional","affiliation":[{"name":"Septomics Research Center School of Medicine Jena University Hospital Jena Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne\u2010Sophie","family":"Endres","sequence":"additional","affiliation":[{"name":"Evangelisches Geriatriezentum Berlin Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michaela","family":"Schmidtke","sequence":"additional","affiliation":[{"name":"Department of Virology and Antiviral Therapy School of Medicine Jena University Hospital Jena Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg","family":"Hofmann","sequence":"additional","affiliation":[{"name":"Institute of Medical Virology, Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hortense","family":"Slevogt","sequence":"additional","affiliation":[{"name":"Septomics Research Center School of Medicine Jena University Hospital Jena Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3,15]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"World Health Organization(2016)Chronic respiratory diseases. 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