{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:34:34Z","timestamp":1791362074551,"version":"4.3.1"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,3,2]],"date-time":"2016-03-02T00:00:00Z","timestamp":1456876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004825","name":"Nordea-fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008368","name":"Gigtforeningen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008368","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    With this study we investigated the role of nonsteroidal anti\u2010inflammatory drugs (NSAIDs) in human skeletal muscle regeneration. Young men ingested NSAID [1200 mg\/d ibuprofen (IBU)] or placebo (PLA) daily for 2 wk before and 4 wk after an electrical stimulation\u2010induced injury to the leg extensor muscles of one leg. Muscle biopsies were collected from the vastus lateralis muscles before and after stimulation (2.5 h and 2,7, and 30 d) and were assessed for satellite cells and regeneration by immunohistochemistry and real\u2010time RT\u2010PCR, and we also measured telomere length. After injury, and compared with PLA, IBU was found to augment the proportion of ActiveNotch1\n                    <jats:sup>+<\/jats:sup>\n                    satellite cells at 2 d [IBU, 29 \u00b1 3%\n                    <jats:italic>vs.<\/jats:italic>\n                    PLA, 19 \u00b1 2% (means \u00b1\n                    <jats:sc>sem<\/jats:sc>\n                    )], satellite cell content at 7 d [IBU, 0.16 \u00b1 0.01\n                    <jats:italic>vs.<\/jats:italic>\n                    PLA, 0.12 \u00b1 0.01 (Pax7\n                    <jats:sup>+<\/jats:sup>\n                    cells\/fiber)], and to expedite muscle repair at 30 d. The PLA group displayed a greater proportion of embryonic myosin\n                    <jats:sup>+<\/jats:sup>\n                    fibers and a residual ~2\u2010fold increase in mRNA levels of matrix proteins (all\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05). Endomysial collagen was also elevated with PLA at 30 d. Minimum telomere length shortening was not observed. In conclusion, ingestion of NSAID has a potentiating effect on Notch activation of satellite cells and muscle remodeling during large\u2010scale regeneration of injured human skeletal muscle.\u2014Mackey, A. L., Rasmussen, L. K., Kadi, F., Schjerling, P., Helmark, I. C., Ponsot, E., Aagaard, P., Durigan, J. L. Q., Kjaer, M. Activation of satellite cells and the regeneration of human skeletal muscle are expedited by ingestion of nonsteroidal anti\u2010inflammatory medication. FASEB J. 30, 2266\u20132281 (2016).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201500198r","type":"journal-article","created":{"date-parts":[[2016,3,2]],"date-time":"2016-03-02T23:03:09Z","timestamp":1456959789000},"page":"2266-2281","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":92,"title":["Activation of satellite cells and the regeneration of human skeletal muscle are expedited by ingestion of nonsteroidal anti\u2010inflammatory medication"],"prefix":"10.1096","volume":"30","author":[{"given":"Abigail L.","family":"Mackey","sequence":"first","affiliation":[{"name":"Institute of Sports Medicine Copenhagen Department of Orthopaedic Surgery M Bispebjerg Hospital Copenhagen Denmark"},{"name":"Department of Biomedical Sciences Center for Healthy Aging Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lotte K.","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Institute of Sports Medicine Copenhagen Department of Orthopaedic Surgery M Bispebjerg Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fawzi","family":"Kadi","sequence":"additional","affiliation":[{"name":"School of Health and Medical Sciences \u00d6rebro University \u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Schjerling","sequence":"additional","affiliation":[{"name":"Institute of Sports Medicine Copenhagen Department of Orthopaedic Surgery M Bispebjerg Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida C.","family":"Helmark","sequence":"additional","affiliation":[{"name":"Institute of Sports Medicine Copenhagen Department of Orthopaedic Surgery M Bispebjerg Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elodie","family":"Ponsot","sequence":"additional","affiliation":[{"name":"School of Health and Medical Sciences \u00d6rebro University \u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Aagaard","sequence":"additional","affiliation":[{"name":"Department of Sports Science and Clinical Biomechanics, Muscle Research Cluster University of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Luiz Q.","family":"Durigan","sequence":"additional","affiliation":[{"name":"Physical Therapy Division University of Bras\u00edlia Bras\u00edlia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kjaer","sequence":"additional","affiliation":[{"name":"Institute of Sports Medicine Copenhagen Department of Orthopaedic Surgery M Bispebjerg Hospital Copenhagen Denmark"},{"name":"Department of Biomedical Sciences Center for Healthy Aging Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.069088"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.068858"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.13-239426"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00036.2013"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00061.2013"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0838.2012.01463.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.32098\/mltj.04.2013.16"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1288"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00157.2007"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00707.2009"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2014.09.010"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.10-176487"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.136648"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps.2013-03300"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(02)00254-X"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2007.10.006"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.775"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.773"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.128827"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.90952.2008"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00283.2002"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00789.2010"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.200900045"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0084122"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200700290"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10522-009-9260-0"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2014.04.020"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3869"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1089\/hum.1997.8.12-1429"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1249\/01.MSS.0000084522.14168.49"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1249\/mss.0b013e3181596695"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-010-1353-6"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2011.063818"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.11.049"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.201500198R","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1096\/fj.201500198R","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.201500198R","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T22:57:34Z","timestamp":1761692254000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.201500198R"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,2]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1096\/fj.201500198R"],"URL":"https:\/\/doi.org\/10.1096\/fj.201500198r","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.726191348.793532440","asserted-by":"object"}]},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,2]]},"assertion":[{"value":"2015-10-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-02-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-03-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}