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Some carriers are affected by the neurodegenerative disorder fragile X\u2010associated tremor\/ataxia syndrome (FXTAS), primary ovarian insufficiency, and neurobehavioral impairments. Based on the mitochondrial dysfunction observed in fibroblasts and brain samples from carriers, as well as in neurons and brains from a mouse model of the premutation, we evaluated the presence of the Warburg effect in peripheral blood mononuclear cells (PBMCs) from 30 premutation carriers with either a rebalance of the metabolism [increasing glycolysis while decreasing oxidative phosphorylation (oxphos)] or a metabolic amplification (increasing glycolysis while maintaining\/increasing oxphos). Deficits in oxphos\u2014more pronounced in FXTAS\u2010affected subjects\u2014were accompanied by a shift toward glycolysis, suggesting increased glycolysis despite aerobic conditions. Differential proteomics extended these findings, unveiling a decreased antioxidant response, translation, and disrupted extra\u2010cellular matrix and cytoskeleton organization with activation of prosenescence pathways. Lower bioenergetics segregated with increased incidence of low executive function, tremors, below\u2010average IQ, and FXTAS. The combination of functional and proteomic data unveiled new mechanisms related to energy production in the premutation, showing the potential of being applicable to other psychiatric disorders to identify endophenotypespecific responses relevant to neurobiology.\u2014Napoli, E., Song, G., Schneider, A., Hagerman, R., Eldeeb, M.A.A.A., Azarang, A., Tassone, F., Giulivi, C. Warburg effect linked to cognitive\u2010executive deficits in\n                    <jats:italic>FMR1<\/jats:italic>\n                    premutation. FASEB J. 30, 3334\u20133351 (2016).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201600315r","type":"journal-article","created":{"date-parts":[[2016,6,22]],"date-time":"2016-06-22T23:03:58Z","timestamp":1466636638000},"page":"3334-3351","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Warburg effect linked to cognitive\u2010executive deficits in\n                    <i>FMR1<\/i>\n                    premutation"],"prefix":"10.1096","volume":"30","author":[{"given":"Eleonora","family":"Napoli","sequence":"first","affiliation":[{"name":"Department of Molecular Biosciences School of Veterinary Medicine University of California  Davis Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyu","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Molecular Biosciences School of Veterinary Medicine University of California  Davis Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Schneider","sequence":"additional","affiliation":[{"name":"Medical Investigations of Neurodevelopmental Disorders (MIND) Institute University of California  Davis Davis California USA"},{"name":"Department of Pediatrics University of California Davis Medical Center  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randi","family":"Hagerman","sequence":"additional","affiliation":[{"name":"Medical Investigations of Neurodevelopmental Disorders (MIND) Institute University of California  Davis Davis California USA"},{"name":"Department of Pediatrics University of California Davis Medical Center  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa Abd Al Azaim","family":"Eldeeb","sequence":"additional","affiliation":[{"name":"Medical Investigations of Neurodevelopmental Disorders (MIND) Institute University of California  Davis Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atoosa","family":"Azarang","sequence":"additional","affiliation":[{"name":"Medical Investigations of Neurodevelopmental Disorders (MIND) Institute University of California  Davis Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flora","family":"Tassone","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Medicine School of Medicine University of California  Davis Davis California USA"},{"name":"Medical Investigations of Neurodevelopmental Disorders (MIND) Institute University of California  Davis Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Giulivi","sequence":"additional","affiliation":[{"name":"Department of Molecular Biosciences School of Veterinary Medicine University of California  Davis Davis California USA"},{"name":"Department of Pediatrics University of California Davis Medical Center  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70125-X"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-2728(00)00242-5"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20091960"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr211"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(94)90056-6"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2011.157"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2011.11.001"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.4.1964"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2975"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e3280adc943"},{"key":"e_1_2_8_12_1","first-page":"97","article-title":"Neuroinflammatory responses to traumatic brain injury: etiology, clinical consequences, and therapeutic opportunities","volume":"11","author":"Lozano D.","year":"2015","journal-title":"Neuropsychiatr. 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