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Despite its high medical importance, the molecular mechanisms controlling progression from simple liver steatosis to NASH remain elusive. We recently identified serine\/threonine protein kinase (STK)25 as a critical regulator of ectopic lipid deposition, systemic glucose, and insulin homeostasis. To elucidate the role of\n                    <jats:italic>STK25<\/jats:italic>\n                    in the development of NASH, we challenged Stk25\u2010knockout and transgenic mice with a methionine and choline\u2010deficient (MCD) diet. We show that\n                    <jats:italic>Stk25<\/jats:italic>\n                    <jats:sup>\u2010\/\u2010<\/jats:sup>\n                    mice are protected against MCD\u2010diet\u2013 induced NASH, as evidenced by repressed liver steatosis, oxidative damage, inflammation, and fibrosis, whereas\n                    <jats:italic>STK25<\/jats:italic>\n                    transgenic mice developed a more severe NASH phenotype, compared with corresponding wild\u2010type littermates. Consistently, NASH features were suppressed in STK25\u2010deficient human hepatocytes cultured in MCD medium, and reciprocally enhanced in STK25\u2010overexpressing cells. We also found a significant positive correlation in human liver biopsies between\n                    <jats:italic>STK25<\/jats:italic>\n                    expression and NASH development. The study provides evidence for multiple roles of\n                    <jats:italic>STK25<\/jats:italic>\n                    in NASH pathogenesis and future investigations to address the potential therapeutic relevance of pharmacological\n                    <jats:italic>STK25<\/jats:italic>\n                    inhibitors in prevention and treatment of NASH are warranted.\u2014Amrutkar, M., Chursa, U., Kern, M., Nu\u00f1ez\u2010Dur\u00e1n, E., St\u00e5hlman, M., S\u00fctt, S., Bor\u00e9n, J., Johansson, B. R., Marschall, H.\u2010U., Bl\u00fcher, M., Mahlapuu, M. STK25 is a critical determinant in nonalcoholic steatohepatitis. FASEB J. 30, 3628\u20133643 (2016).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201600562r","type":"journal-article","created":{"date-parts":[[2016,7,15]],"date-time":"2016-07-15T20:40:17Z","timestamp":1468615217000},"page":"3628-3643","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["STK25 is a critical determinant in nonalcoholic steatohepatitis"],"prefix":"10.1096","volume":"30","author":[{"given":"Manoj","family":"Amrutkar","sequence":"first","affiliation":[{"name":"Lundberg Laboratory for Diabetes Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urszula","family":"Chursa","sequence":"additional","affiliation":[{"name":"Lundberg Laboratory for Diabetes 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