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Labor per se is considered a sterile inflammatory process. Intra\u2010amniotic inflammation (IAI) due to microorganisms (\n                    <jats:italic>i.e<\/jats:italic>\n                    ., intra\u2010amniotic infection) or danger signals (\n                    <jats:italic>i.e<\/jats:italic>\n                    ., sterile IAI) has been implicated in the pathogenesis of preterm labor and clinical chorioamnionitis at term. Early and accurate diagnosis of microbial invasion of the amniotic cavity (MIAC) requires analysis of amniotic fluid (AF). It is possible that IAI caused by microorganisms is associated with a stereotypic lipidomic profile, and that analysis of AF may help in the identification of patients with this condition. To test this hypothesis, we analyzed the fatty acyl lipidome of AF by liquid chromatography\u2014mass spectrometry from patients in spontaneous labor at term and preterm gestations. We report that the AF concentrations of proinflammatory lipid mediators of the 5\u2010lipoxygenase pathway are significantly higher in MIAC than in cases of sterile IAI. These results suggest that the concentrations of 5\u2010lipoxygenase metabolites of arachidonic acid, 5\u2010hydroxyeicosatetraenoic acid, and leukotriene B4 in particular could serve as potential biomarkers of MIAC. This finding could have important implications for the rapid identification of patients who may benefit from antimicrobial treatment.\u2014Maddipati, K. R., Romero, R., Chaiworapongsa, T., Chaemsaithong, P., Zhou, S.\u2010L., Xu, Z., Tarca, A. L., Kusanovic, J. P., Gomez, R., Chaiyasit, N., Honn, K. V. Lipidomic analysis of patients with microbial invasion of the amniotic cavity reveals up\u2010regulation of leukotriene B\n                    <jats:sub>4<\/jats:sub>\n                    . FASEBJ. 30, 3296\u20133307 (2016).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201600583r","type":"journal-article","created":{"date-parts":[[2016,6,16]],"date-time":"2016-06-16T23:11:22Z","timestamp":1466118682000},"page":"3296-3307","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Lipidomic analysis of patients with microbial invasion of the amniotic cavity reveals up\u2010regulation of leukotriene B\n                    <sub>4<\/sub>"],"prefix":"10.1096","volume":"30","author":[{"given":"Krishna Rao","family":"Maddipati","sequence":"first","affiliation":[{"name":"Department of Pathology Wayne State University School of Medicine  Detroit Michigan USA"},{"name":"Lipidomics Core Facility Wayne State University School of Medicine  Detroit Michigan 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