{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:07:10Z","timestamp":1790482030815,"version":"4.1.0"},"reference-count":62,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,9,20]],"date-time":"2016-09-20T00:00:00Z","timestamp":1474329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>\n                    Hypertension is a key risk factor for heart failure, with the latter characterized by diaphragm muscle weakness that is mediated in part by increased oxidative stress. In the present study, we used a deoxycorticosterone acetate (DOCA)\u2010salt mouse model to determine whether hypertension could independently induce diaphragm dysfunction and further investigated the effects of high\u2010intensity interval training (HIIT). Sham\u2010treated (\n                    <jats:italic>n<\/jats:italic>\n                    = 11), DOCA\u2010salt\u2010treated (\n                    <jats:italic>n<\/jats:italic>\n                    = 11), and DOCA\u2010salt+HIIT\u2010treated (\n                    <jats:italic>n<\/jats:italic>\n                    = 15) mice were studied over 4 wk. Diaphragm contractile function, protein expression, enzyme activity, and fiber cross\u2010sectional area and type were subsequently determined. Elevated blood pressure confirmed hypertension in DOCA\u2010salt mice independent of HIIT (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05). Diaphragm forces were impaired by ~15\u201320% in DOCA\u2010salt\n                    <jats:italic>vs<\/jats:italic>\n                    . sham\u2010treated mice (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05), but this effect was prevented after HIIT. Myosin heavy chain (MyHC) protein expression tended to decrease (~30%; P = 0.06) in DOCA\u2010salt\n                    <jats:italic>vs<\/jats:italic>\n                    . sham\u2010 and DOCA\u2010salt+HIIT mice, whereas oxidative stress increased (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05). Enzyme activity of NADPH oxidase was higher, but superoxide dismutase was lower, with MyHC oxidation elevated by ~50%. HIIT further prevented direct oxidant\u2010mediated diaphragmcontractile dysfunction (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05) after a 30 min exposure to H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    (1 mM). Our data suggest that hypertension induces diaphragm contractile dysfunction\n                    <jats:italic>via<\/jats:italic>\n                    an oxidantmediated mechanism that is prevented by HIIT.\u2014Bowen, T. S., Eisenkolb, S., Drobner, J., Fischer, T., Werner, S., Linke, A., Mangner, N., Schuler, G., Adams, V. High\u2010intensity interval training prevents oxidantmediated diaphragm muscle weakness in hypertensive mice. FASEB J. 31, 60\u201371 (2017)\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201600672r","type":"journal-article","created":{"date-parts":[[2016,9,20]],"date-time":"2016-09-20T23:28:47Z","timestamp":1474414127000},"page":"60-71","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["High\u2010intensity interval training prevents oxidantmediated diaphragm muscle weakness in hypertensive mice"],"prefix":"10.1096","volume":"31","author":[{"given":"T. Scott","family":"Bowen","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Cardiology Leipzig University Heart Center  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Eisenkolb","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Cardiology Leipzig University Heart Center  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliane","family":"Drobner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Cardiology Leipzig University Heart Center  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Cardiology Leipzig University Heart Center  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Werner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Cardiology Leipzig University Heart Center  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Linke","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Cardiology Leipzig University Heart Center  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman","family":"Mangner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Cardiology Leipzig University Heart Center  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Schuler","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Cardiology Leipzig University Heart Center  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Adams","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Cardiology Leipzig University Heart Center  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,20]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"416","article-title":"ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: the Task Force for the diagnosis and treatment of acute and chronic heart failure 2008 of the European Society of Cardiology. 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