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Reproductive success is of prime importance for the survival of every species. The highly conserved and ubiquitously expressed serum glucocorticoid\u2010regulated kinase 1 (SGK1) was first implicated in infertility as a regulator of a Na+ channel. In this review, we emphasize the prominent role of\n                    <jats:italic>SGK1<\/jats:italic>\n                    during early pregnancy: 1) balancing uterine luminal fluid secretion and reabsorption to aid blastocyst adhesion and to import nutrients and energy; 2) transducing signals from the blastocyst to the receptive endometrium; 3) inducing multiple genes that are involved in uterine receptivity and trophoblast invasion; 4) regulating cell differentiation and antioxidant defenses at the fetomaternal interface; and 5) contributing to the proliferation and survival of decidual stromal cells. Accordingly,\n                    <jats:italic>SGK1<\/jats:italic>\n                    coordinates many cellular processes that are crucial to reproductive activities. Aberrant expression or function of\n                    <jats:italic>SGK1<\/jats:italic>\n                    results in implantation failure and early pregnancy loss. Further investigation of the molecular mechanisms of the function of\n                    <jats:italic>SGK1<\/jats:italic>\n                    might provide novel diagnostic tools and interventions for reproductive complications.\u2014Lou, Y., Hu, M., Mao, L., Zheng, Y., Jin, F. Involvement of serum glucocorticoid\u2010regulated kinase 1 in reproductive success. FASEB J. 31, 447\u2013456 (2017).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201600760r","type":"journal-article","created":{"date-parts":[[2016,11,10]],"date-time":"2016-11-10T08:44:34Z","timestamp":1478767474000},"page":"447-456","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Involvement of serum glucocorticoid\u2010regulated kinase 1 in reproductive success"],"prefix":"10.1096","volume":"31","author":[{"given":"Yiyun","family":"Lou","sequence":"first","affiliation":[{"name":"Department of Reproductive Endocrinology Women's Hospital Zhejiang University School of Medicine Zhejiang China"},{"name":"Department of Gynaecology Hangzhou Hospital of Traditional Chinese Medicine Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minhao","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Reproductive Endocrinology Women's Hospital Zhejiang University School of Medicine Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luna","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Reproductive Endocrinology Women's Hospital Zhejiang University School of Medicine Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingming","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Reproductive Endocrinology Women's Hospital Zhejiang University School of Medicine Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Reproductive Endocrinology Women's Hospital Zhejiang University School of Medicine Zhejiang China"},{"name":"Department of Biochemistry and Genetics Zhejiang University School of Medicine Zhejiang China"},{"name":"Key Laboratory of Reproductive Genetics National Ministry of Education, Zhejiang University Zhejiang China"},{"name":"Women's Reproductive Health Laboratory of Zhejiang Province National Ministry of Education, Zhejiang University Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20102103"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1006\/geno.1998.5258","article-title":"Genomic organization and chromosomal localization of the human SGK protein kinase gene","volume":"51","author":"Waldegger S.","year":"1998","journal-title":"Genomics"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00050.2005"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.14310\/horm.2002.1401"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20082202"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2016.15"},{"key":"e_1_2_9_8_1","first-page":"271","article-title":"3\u2010Phosphoinositide\u2010dependent protein kinase\u20101 as an emerging target in the management of breast cancer","volume":"5","author":"Fyffe C.","year":"2013","journal-title":"Cancer Manag. 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