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Because ES prevention is problematic, intervention is needed, yet the mechanisms that underlie ES remain largely unknown. So far, the role of early nutrition in brain programming has been largely ignored. Here, we demonstrate that essential 1\u2010carbon metabolism\u2010associated micronutrients (1\u2010CMAMs; i.e., methionine and B vitamins) early in life are crucial in programming later cognition by ES. ES was induced in male C57Bl\/6 mice from postnatal d (P)2\u20139. 1\u2010CMAM levels were measured centrally and peripherally by using liquid chromatography\u2010mass spectroscopy. Next, we supplemented the maternal diet with 1\u2010CMAM only during the ES period and studied cognitive, neuroendocrine, neurogenic, transcriptional, and epigenetic changes in adult offspring. We demonstrate that ES specifically reduces methionine in offspring plasma and brain. Of note, dietary 1\u2010CMAM enrichment during P2\u20139 restored methionine levels and rescued ES\u2010induced adult cognitive impairments. Beneficial effects of this early dietary enrichment were associated with prevention of the ES\u2010induced rise in corticosterone and adrenal gland hypertrophy did not involve changes in maternal care, hippocampal volume, neurogenesis, or global\/\n                    <jats:italic>Nr3c1<\/jats:italic>\n                    \u2010specific DNA methylation. In summary, nutrition is important in brain programming by ES. A short, early supplementation with essential micronutrients can already prevent lasting effects of ES. This concept opens new avenues for nutritional intervention.\u2014Naninck, E. F. G., Oosterink, J. E., Yam, K.\u2010Y., de Vries, L. P., Schierbeek, H., van Goudoever, J. B., Verkaik\u2010Schakel, R.\u2010N., Plantinga, J. A., Plosch, T., Lucassen, P. J., Korosi, A. Early micronutrient supplementation protects against early stress\u2010induced cognitive impairments. FASEB J. 31, 505\u2013518 (2017).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">http:\/\/www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201600834r","type":"journal-article","created":{"date-parts":[[2016,10,21]],"date-time":"2016-10-21T23:41:05Z","timestamp":1477093265000},"page":"505-518","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Early micronutrient supplementation protects against early stress\u2010induced cognitive impairments"],"prefix":"10.1096","volume":"31","author":[{"given":"Eva F. G.","family":"Naninck","sequence":"first","affiliation":[{"name":"Swammerdam Institute for Life Sciences, Center for Neuroscience University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Efraim","family":"Oosterink","sequence":"additional","affiliation":[{"name":"Department of Mother and Child, Emma Children's Hospital Academic Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kit\u2010Yi","family":"Yam","sequence":"additional","affiliation":[{"name":"Swammerdam Institute for Life Sciences, Center for Neuroscience University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lennart P.","family":"de Vries","sequence":"additional","affiliation":[{"name":"Swammerdam Institute for Life Sciences, Center for Neuroscience University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henk","family":"Schierbeek","sequence":"additional","affiliation":[{"name":"Department of Mother and Child, Emma Children's Hospital Academic Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes B.","family":"van Goudoever","sequence":"additional","affiliation":[{"name":"Department of Mother and Child, Emma Children's Hospital Academic Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rikst\u2010Nynke","family":"Verkaik\u2010Schakel","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University Medical Center Groningen, University of Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e8e A.","family":"Plantinga","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University Medical Center Groningen, University of Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten","family":"Plosch","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University Medical Center Groningen, University of Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Lucassen","sequence":"additional","affiliation":[{"name":"Swammerdam Institute for Life Sciences, Center for Neuroscience University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aniko","family":"Korosi","sequence":"additional","affiliation":[{"name":"Swammerdam Institute for Life Sciences, Center for Neuroscience University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2012.12.012"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2014.04.020"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.21230"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5332.1659"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-7687.2009.00890.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1276"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/FBP.0000000000000147"},{"key":"e_1_2_8_9_1","article-title":"Hippocampal dysfunction and cognitive impairments provoked by chronic early\u2010life stress involve excessive activation of CRH receptors","volume":"30","author":"Ivy A. 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