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It has been replicated in an animal model of human inflammatory demyelinating polyradiculoneuropathy, Guillain\u2010Barr\u00e9 syndrome. In this study, we evaluated the therapeutic efficacy of a selective inhibitor of the immunoproteasome subunit, low\u2010MW polypeptide 7 (PR\u2010957) in rats with EAN. Our results showed that PR\u2010957 significantly delayed onset day, reduced severity and shortened duration of EAN, and alleviated demyelination and inflammatory infiltration in sciatic nerves. In addition to significantly regulating expression of the cytokine profile, PR\u2010957 treatment down\u2010regulated the proportion of proinflammatory T\u2010helper (T\n                    <jats:sub>h<\/jats:sub>\n                    )17 cells in sciatic nerves and spleens of rats with EAN. Data presented show the role of PR\u2010957 in the signal transducer and activator of transcription 3 (STAT3) pathway. PR\u2010957 not only decreased expression of IL\u20106 and IL\u201023 but also led to down\u2010regulation of STAT3 phosphorylation in CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells. Regulation of the STAT3 pathway led to a reduction in retinoid\u2010related orphan nuclear receptor \u03b3 t and IL\u201017 production. Furthermore, reduction of STAT3 phosphorylation may have directly suppressed T\n                    <jats:sub>h<\/jats:sub>\n                    17\u2010cell differentiation. Therefore, our study demonstrates that PR\u2010957 could potently alleviate inflammation in rats with EAN and that it may be a likely candidate for treating Guillain\u2010Barr\u00e9 syndrome. \u2014Liu, H., Wan, C., Ding, Y., Han, R., He, Y., Xiao, J., Hao, J. PR\u2010957, a selective inhibitor of immunoproteasome subunit low\u2010MW polypeptide 7, attenuates experimental autoimmune neuritis by suppressing T\n                    <jats:sub>h<\/jats:sub>\n                    17\u2010cell differentiation and regulating cytokine production.\n                    <jats:italic>FASEB J<\/jats:italic>\n                    . 31, 1756\u20131766 (2017)\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201601147r","type":"journal-article","created":{"date-parts":[[2017,1,17]],"date-time":"2017-01-17T22:11:31Z","timestamp":1484691091000},"page":"1756-1766","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["PR\u2010957, a selective inhibitor of immunoproteasome subunit low\u2010MW polypeptide 7, attenuates experimental autoimmune neuritis by suppressing T\n                    <sub>h<\/sub>\n                    17\u2010cell differentiation and regulating cytokine production"],"prefix":"10.1096","volume":"31","author":[{"given":"Haijie","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Neurology Tianjin Neurological Institute  Tianjin China"},{"name":"Department of Physical Medicine and Rehabilitation Tianjin Medical University General Hospital  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunxiao","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Tianjin Medical University General Hospital  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanan","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Neurology Tianjin Neurological Institute  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranran","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Neurology Tianjin Neurological Institute  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yating","family":"He","sequence":"additional","affiliation":[{"name":"Department of Neurology Tianjin Neurological Institute  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinting","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Neurology Tianjin Neurological Institute  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junwei","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Neurology Tianjin Neurological Institute  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,1,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"e193\u2013e201","DOI":"10.1016\/j.lpm.2013.02.328","article-title":"Diagnosis, treatment and prognosis of Guillain\u2010Barr\u00e9 syndrome (GBS)","volume":"42","author":"Van Doorn P. 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