{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:08:41Z","timestamp":1789949321919,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,1,30]],"date-time":"2017-01-30T00:00:00Z","timestamp":1485734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2010\/51078-1"],"award-info":[{"award-number":["2010\/51078-1"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2012\/500790-0"],"award-info":[{"award-number":["2012\/500790-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2015\/19259-0"],"award-info":[{"award-number":["2015\/19259-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["311966\/2015-2"],"award-info":[{"award-number":["311966\/2015-2"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Cancer cachexia is a multifactorial syndrome characterized by body weight loss, atrophy of adipose tissue (AT) and systemic inflammation. However, there is limited information regarding the mechanisms of immunometabolic response in AT from cancer cachexia. Male Wistar rats were inoculated with 2 \u00d7 10\n                    <jats:sup>7<\/jats:sup>\n                    of Walker 256 tumor cells [tumor bearing (TB) rats]. The mesenteric AT (MeAT) was collected on d 0, 4, 7 (early stage), and 14 (cachexia stage) after tumor cell injection. Surgical biopsies for MeAT were obtained from patients who had gastrointestinal cancer with cachexia. Lipolysis showed an early decrease in glycerol release in TB d 4 (TB4) rats in relation to the control, followed by a 6\u2010fold increase in TB14 rats, whereas de novo lipogenesis was markedly lower in the incorporation of glucose into fatty acids in TB14 rats during the development of cachexia. CD11b and CD68 were positive in TB7 and TB14 rats, respectively. In addition, we found cachexia stage results similar to those of animals in MeAT from patients: an increased presence of CD68\n                    <jats:sup>+<\/jats:sup>\n                    , iNOS2\n                    <jats:sup>+<\/jats:sup>\n                    , TNF\u03b1\n                    <jats:sup>+<\/jats:sup>\n                    , and HSL\n                    <jats:sup>+<\/jats:sup>\n                    cells. In summary, translational analysis of MeAT from patients and an animal model of cancer cachexia enabled us to identify early disruption in Adl turnover and subsequent inflammatory response during the development of cancer cachexia.\u2014Henriques, F. S., Serti\u00e9, R. A. L., Franco, F. O., Knobl, P., Neves, R. X., Andreotti, S., Lima, F. B., Guilherme, A., Seelaender, M., Batista, M. L., Jr. Early suppression of adipocyte lipid turnover induces immunometabolic modulation in cancer cachexia syndrome. FASEB J. 31, 1976\u20131986 (2017).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201601151r","type":"journal-article","created":{"date-parts":[[2017,1,30]],"date-time":"2017-01-30T21:50:37Z","timestamp":1485813037000},"page":"1976-1986","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Early suppression of adipocyte lipid turnover induces immunometabolic modulation in cancer cachexia syndrome"],"prefix":"10.1096","volume":"31","author":[{"given":"Felipe Santos","family":"Henriques","sequence":"first","affiliation":[{"name":"Laboratory of Adipose Tissue Biology Integrated Group of Biotechnology University of Mogi das Cruzes S\u00e3o Paulo Brazil"},{"name":"Program in Molecular Medicine University of Massachusetts Medical School Worcester Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rog\u00e9rio","family":"Ant\u00f4nio Laurato Serti\u00e9","sequence":"additional","affiliation":[{"name":"Laboratory of Physiology S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe Oliveira","family":"Franco","sequence":"additional","affiliation":[{"name":"Laboratory of Adipose Tissue Biology Integrated Group of Biotechnology University of Mogi das Cruzes S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Knobl","sequence":"additional","affiliation":[{"name":"Laboratory of Adipose Tissue Biology Integrated Group of Biotechnology University of Mogi das Cruzes S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Xavier","family":"Neves","sequence":"additional","affiliation":[{"name":"Cancer Metabolism Research Group Institute of Biomedical Sciences University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Andreotti","sequence":"additional","affiliation":[{"name":"Laboratory of Physiology S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio Bessa","family":"Lima","sequence":"additional","affiliation":[{"name":"Laboratory of Physiology S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adilson","family":"Guilherme","sequence":"additional","affiliation":[{"name":"Laboratory of Physiology S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilia","family":"Seelaender","sequence":"additional","affiliation":[{"name":"Cancer Metabolism Research Group Institute of Biomedical Sciences University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Miguel Luiz","family":"Batista","sequence":"additional","affiliation":[{"name":"Laboratory of Adipose Tissue Biology Integrated Group of Biotechnology University of Mogi das Cruzes S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2015.10.039"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1209418"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.currproblcancer.2011.01.001"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3829"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-12-0307"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.4161\/15384047.2014.987075"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu6115280"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13528"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.06.011"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12037"},{"key":"e_1_2_8_12_1","doi-asserted-by":"crossref","unstructured":"Franco F. 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