{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:06:48Z","timestamp":1790467608490,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,9,19]],"date-time":"2017-09-19T00:00:00Z","timestamp":1505779200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Lysyl oxidase (LOX) controls matrix remodeling, a key process that underlies cardiovascular diseases and heart failure; however, a lack of suitable animal models has limited our knowledge with regard to the contribution of LOX to cardiac dysfunction. Here, we assessed the impact of LOX overexpression on ventricular function and cardiac hypertrophy in a transgenic LOX (TgLOX) mouse model with a strong cardiac expression of human LOX. TgLOX mice exhibited high expression of the transgene in cardiomyocytes and cardiofibroblasts, which are associated with enhanced LOX activity and H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    production and with cardiofibroblast reprogramming. LOX overexpression promoted an age\u2010associated concentric remodeling of the left ventricle and impaired diastolic function. Furthermore, LOX transgenesis aggravated angiotensin II (Ang II)\u2013induced cardiac hypertrophy and dysfunction, which triggered a greater fibrotic response that was characterized by stronger collagen deposition and cross\u2010linking and high expression of fibrotic markers. In addition, LOX transgenesis increased the Ang II\u2013induced myocardial inflammatory infiltrate, exacerbated expression of proinflammatory markers, and decreased that of cardioprotective factors. Mechanistically, LOX overexpression enhanced oxidative stress and potentiated the Ang II\u2013mediated cardiac activation of p38 MAPK while reducing AMPK activation. Our findings suggest that LOX induces an age\u2010dependent disturbance of diastolic function and aggravates Ang II\u2013induced hypertrophy, which provides novel insights into the role of LOX in cardiac performance.\u2014Gal\u00e1n, M., Varona, S., Guadall, A., Orriols, M., Navas, M., Aguil\u00f3, S., deDiego, A., Navarro, M. A., Garc\u00eda\u2010Dorado, D., Rodr\u00edguez\u2010Sinovas, A., Mart\u00ednez\u2010Gonz\u00e1lez, J., Rodriguez, C. Lysyl oxidase overexpression accelerates cardiac remodeling and aggravates angiotensin II\u2013induced hypertrophy. FASEB J. 31, 3787\u20133799 (2017).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                    \u2014Gal\u00e1n, Mar\u00eda, Varona, Saray, Guadall, Anna, Orriols, Mar, Navas, Miquel, Aguil\u00f3, Silvia, de Diego, Alicia, Navarro, Mar\u00eda A., Garc\u00eda\u2010Dorado, David, Rodr\u00edguez\u2010Sinovas, Antonio, Mart\u00ednez\u2010Gonz\u00e1lez, Jos\u00e9, Rodriguez, Cristina Lysyl oxidase overexpression accelerates cardiac remodeling and aggravates angiotensin II\u2013induced hypertrophy. FASEB J. 31, 3787\u20133799 (2017)\n                  <\/jats:p>","DOI":"10.1096\/fj.201601157rr","type":"journal-article","created":{"date-parts":[[2017,5,18]],"date-time":"2017-05-18T20:40:25Z","timestamp":1495140025000},"page":"3787-3799","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Lysyl oxidase overexpression accelerates cardiac remodeling and aggravates angiotensin II\u2013induced hypertrophy"],"prefix":"10.1096","volume":"31","author":[{"given":"Mar\u00eda","family":"Gal\u00e1n","sequence":"first","affiliation":[{"name":"Institut Catal\u00e0 de Ci\u00e8ncies Cardiovasculars  Barcelona Spain"},{"name":"Laboratorio de Angiolog\u00eda Biolog\u00eda Vascular e Inflamaci\u00f3n y Servicio de Cirug\u00eda Vascular del Hospital de la Santa Creu i Sant Pau  Barcelona Spain"},{"name":"Institut d\u2019Investigaci\u00f3 Biom\u00e8dica (IIB)\u2013Sant Pau  Barcelona Spain"},{"name":"Centro de Investigati\u00f3n 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