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We analyzed\n                    <jats:italic>XDH1<\/jats:italic>\n                    and\n                    <jats:italic>XDH2<\/jats:italic>\n                    gene expression by real\u2010time quantitative PCR in tissues from sugar\u2010 and blood\u2010fed females. Differential\n                    <jats:italic>XDH1<\/jats:italic>\n                    and\n                    <jats:italic>XDH2<\/jats:italic>\n                    gene expression was observed in tissues dissected throughout a time course. We next exposed females to blood meals supplemented with allopurinol, a well\u2010characterized XDH inhibitor. We also tested the effects of injecting double\u2010stranded RNA (dsRNA) against XDH1, XDH2, or both. Disruption of XDH by allopurinol or XDH1 by RNA interference significantly affected mosquito survival, causing a disruption in blood digestion, excretion, oviposition, and reproduction. XDH1\u2010deficient mosquitoes showed a persistence of serine proteases in the midgut at 48 h after blood feeding and a reduction in the uptake of vitellogenin by the ovaries. Surprisingly, analysis of the fat body from dsRNA\u2010XDH1\u2010injected mosquitoes fell into 2 groups: one group was characterized by a reduction of the XDH1 transcript, whereas the other group was characterized by an up\u2010regulation of several transcripts, including XDH1, glutamine synthetase, alanine aminotransferase, catalase, superoxide dismutase, ornithine decarboxylase, glutamate receptor, and ammonia transporter. Our data demonstrate that XDH1 plays an essential role and that XDH1 has the potential to be used as a metabolic target for\n                    <jats:italic>Ae. aegypti<\/jats:italic>\n                    vector control.\u2014Isoe, J., Petchampai, N., Isoe, Y. E., Co, K., Mazzalupo, S., Scaraffia, P. Y. Xanthine dehydrogenase\u20101 silencing in\n                    <jats:italic>Aedes aegypti<\/jats:italic>\n                    mosquitoes promotes a blood feeding\u2013induced adulticidal activity. FASEB J. 31, 2276\u20132286 (2017).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201601185r","type":"journal-article","created":{"date-parts":[[2017,2,8]],"date-time":"2017-02-08T21:10:30Z","timestamp":1486588230000},"page":"2276-2286","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Xanthine dehydrogenase\u20101 silencing in\n                    <i>Aedes aegypti<\/i>\n                    mosquitoes promotes a blood feeding\u2013induced adulticidal activity"],"prefix":"10.1096","volume":"31","author":[{"given":"Jun","family":"Isoe","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry University of Arizona  Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natthida","family":"Petchampai","sequence":"additional","affiliation":[{"name":"Department of Tropical Medicine Vector\u2010Borne Infectious Disease Research Center School of Public Health and Tropical Medicine, Tulane University  New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurika E.","family":"Isoe","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry University of Arizona  Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrina","family":"Co","sequence":"additional","affiliation":[{"name":"Department of Tropical Medicine Vector\u2010Borne Infectious Disease Research Center School of Public Health and Tropical Medicine, Tulane University  New Orleans Louisiana USA"},{"name":"Ryan White Center for Infectious Disease and Global Health Indiana University  Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacy","family":"Mazzalupo","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Medicine University of Arizona  Tucson Arizona USA"},{"name":"Current affiliation: Roche Tissue Diagnostics  Tucson AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia Y.","family":"Scaraffia","sequence":"additional","affiliation":[{"name":"Department of Tropical Medicine Vector\u2010Borne Infectious Disease Research Center School of Public Health and Tropical Medicine, Tulane University  New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,8]]},"reference":[{"key":"e_1_2_8_2_1","article-title":"Dengue fever","volume":"351","author":"Kularatne S. 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