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In studying CRP4 mutant mice, we found that their hearts developed normally, but lack of CRP4 exaggerated multiple parameters of the cardiac stress response to the neurohormone angiotensin II (Ang II). Aiming to dissect the molecular details, we found a link between CRP4 and the cardioprotective cGMP pathway, as well as a multiprotein complex comprising well\u2010known hypertrophy\u2010associated factors.\n                    <jats:italic>S<\/jats:italic>\n                    ignificant enrichment of the cysteine\u2010rich intestinal protein (CRIP)1 in murine hearts lacking CRP4, as well as severe cardiac defects and premature death of CRIP1 and CRP4 morphant zebrafish embryos, further support the notion that depleting CRP4 is incompatible with a proper cardiac development and function. Together, amplified Ang II signaling identified CRP4 as a novel antiremodeling factor regulated, at least to some extent, by cardiac cGMP. \u2014Straubinger, J., Boldt, K., Kuret, A., Deng, L., Krattenmacher, D., Bork, N., Desch, M., Feil, R., Feil, S., Nemer, M., Ueffing, M., Ruth, P., Just, S., Lukowski, R. Amplified pathogenic actions of angio\u2010tensin II in cysteine\u2010rich LIM\u2010only protein 4 negative mouse hearts.\n                    <jats:italic>FASEB J<\/jats:italic>\n                    . 31, 1620\u20131638 (2017)\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201601186","type":"journal-article","created":{"date-parts":[[2017,1,30]],"date-time":"2017-01-30T21:50:37Z","timestamp":1485813037000},"page":"1620-1638","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Amplified pathogenic actions of angiotensin II in cysteine\u2010rich LIM\u2010only protein 4\u2013negative mouse hearts"],"prefix":"10.1096","volume":"31","author":[{"given":"Julia","family":"Straubinger","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Toxicology, and Clinical Pharmacy Institute of Pharmacy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karsten","family":"Boldt","sequence":"additional","affiliation":[{"name":"Institute for Ophthalmic Research Molecular Biology of Retinal Degenerations and Medical Proteome Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Kuret","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Toxicology, and Clinical Pharmacy Institute of Pharmacy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Toxicology, and Clinical Pharmacy Institute of Pharmacy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Krattenmacher","sequence":"additional","affiliation":[{"name":"Molecular Cardiology, Department of Internal Medicine II University of Ulm  Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadja","family":"Bork","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Toxicology, and Clinical Pharmacy Institute of Pharmacy"},{"name":"Institute of Experimental Cardiovascular Research University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Desch","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Toxicology, and Clinical Pharmacy Institute of Pharmacy"},{"name":"Madonnen\u2010Apotheke  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Feil","sequence":"additional","affiliation":[{"name":"Interfaculty Institute of Biochemistry University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Feil","sequence":"additional","affiliation":[{"name":"Interfaculty Institute of Biochemistry University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mona","family":"Nemer","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiac Development and Differentiation, Department of Biochemistry, Immunology and Microbiology University of Ottawa  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marius","family":"Ueffing","sequence":"additional","affiliation":[{"name":"Institute for Ophthalmic Research Molecular Biology of Retinal Degenerations and Medical Proteome Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Ruth","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Toxicology, and Clinical Pharmacy Institute of Pharmacy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen","family":"Just","sequence":"additional","affiliation":[{"name":"Molecular Cardiology, Department of Internal Medicine II University of Ulm  Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Lukowski","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Toxicology, and Clinical Pharmacy Institute of Pharmacy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,1,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.942268"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(93)80373-3"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1101747108"},{"key":"e_1_2_8_5_1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1006\/geno.1996.0028","article-title":"Human ESP1\/CRP2, a member of the LIM domain protein family: characterization of the cDNA and assignment of the gene locus to chromosome 14q32","volume":"31","author":"Karim M. 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