{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T07:40:11Z","timestamp":1792222811381,"version":"4.4.0"},"reference-count":46,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,9,19]],"date-time":"2017-09-19T00:00:00Z","timestamp":1505779200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004043","name":"Kanazawa Medical University","doi-asserted-by":"publisher","award":["H2012-15"],"award-info":[{"award-number":["H2012-15"]}],"id":[{"id":"10.13039\/501100004043","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Sphingomyelin synthase 2 (SMS2) is the synthetic enzyme of sphingomyelin (SM), which regulates membrane fluidity and microdomain structure. SMS2 plays a role in LPS\u2010induced lung injury and inflammation; however, its role in inflammation\u2010mediated tumorigenesis is unclear. We investigated the effect of SMS2 deficiency on dextran sodium sulfate (DSS)\u2013induced murine colitis and found inhibition of DSS\u2010induced inflammation in SMS2\u2010deficient (SMS2\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    ) mice. DSS treatment induced a significant increase in ceramide levels, with a decrease of SM levels in SMS2\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    colon tissue, and demonstrated attenuation of the elevation of both inflammation\u2010related gene expression and proinflammatory cytokines and chemokines, leukocyte infiltration, and MAPK and signal transducer and activator of transcription 3 activation. After undergoing transplantation of wild\u2010type bone marrow, SMS2\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice also exhibited inhibition of DSS\u2010induced inflammation in the colon, which suggested that SMS2 deficiency in bone marrow\u2013derived immune cells was not involved in the inhibition of colitis. Finally, in an azoxymethane\/DSS\u2010induced cancer model, SMS2 deficiency significantly decreased tumor incidence in the colon. Our results demonstrate that SMS2 deficiency inhibits DSS\u2010induced colitis and subsequent colitis\u2010associated colon cancer\n                    <jats:italic>via<\/jats:italic>\n                    inhibition of colon epithelial cell\u2013mediated inflammation; therefore, inhibition of SMS2 may be a potential therapeutic target for human colitis and colorectal cancer.\u2014Ohnishi, T., Hashizume, C., Taniguchi, M., Furumoto, H., Han, J., Gao, R., Kinami, S., Kosaka, T., Okazaki, T. Sphingomyelin synthase 2 deficiency inhibits the induction of murine colitis\u2010associated colon cancer. FASEB J. 31, 3816\u20133830 (2017).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                    \u2014Ohnishi, Toshio, Hashizume, Chieko, Taniguchi, Makoto, Furumoto, Hidehiro, Han, Jia, Gao, Rongfen, Kinami, Shinichi, Kosaka, Takeo, Okazaki, Toshiro Sphingomyelin synthase 2 deficiency inhibits the induction of murine colitis\u2010associated colon cancer. FASEB J. 31, 3816\u20133830 (2017)\n                  <\/jats:p>","DOI":"10.1096\/fj.201601225rr","type":"journal-article","created":{"date-parts":[[2017,5,18]],"date-time":"2017-05-18T20:40:25Z","timestamp":1495140025000},"page":"3816-3830","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Sphingomyelin synthase 2 deficiency inhibits the induction of murine colitis\u2010associated colon cancer"],"prefix":"10.1096","volume":"31","author":[{"given":"Toshio","family":"Ohnishi","sequence":"first","affiliation":[{"name":"Division of General and Digestive Surgery Medical Research Institute Kanazawa Medical University  Uchinada Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chieko","family":"Hashizume","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Immunology Medical Research Institute Kanazawa Medical University  Uchinada 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