{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:05:15Z","timestamp":1791475515077,"version":"4.3.4"},"reference-count":97,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T00:00:00Z","timestamp":1484265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["ERC-2010-AG_268675"],"award-info":[{"award-number":["ERC-2010-AG_268675"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011878","name":"Vlaamse regering","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011878","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    With the consideration of the broad involvement of microRNAs (miRNAs) in the regulation of molecular networks in the brain, it is not surprising that miRNA dysregulation causes neurodegeneration in animal models. miRNA profiling in the human brain has revealed miR\u2010132 as one of the most severely down\u2010regulated miRNAs at the intermediate and late Braak stages of Alzheimer's disease (AD), as well as in other neurodegenerative disorders. Suppression of miR\u2010132 aggravates multiple layers of pathology at the molecular and functional level. We describe the potential therapeutic implications of these findings and suggest miRNA targeting or replacement as a realistic multi\u2010hit, therapeutic strategy for AD. Salta, E., De Strooper, B. microRNA\u2010132: a key noncoding RNA operating in the cellular phase of Alzheimer's disease. FASEB J. 31, 424\u2013433 (2017).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201601308","type":"journal-article","created":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T03:25:15Z","timestamp":1485919515000},"page":"424-433","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":97,"title":["microRNA\u2010132: a key noncoding RNA operating in the cellular phase of Alzheimer's disease"],"prefix":"10.1096","volume":"31","author":[{"given":"Evgenia","family":"Salta","sequence":"first","affiliation":[{"name":"Vlaams Instituut voor Biotechnologie (VIB) Center for Brain and Disease VIB\u2010Leuven Leuven Belgium"},{"name":"Center for Human Genetics Universitaire Ziekenhuizen and Leuven Research Institute for Neuroscience and Disease KU\u2010Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart","family":"De Strooper","sequence":"additional","affiliation":[{"name":"Vlaams Instituut voor Biotechnologie (VIB) Center for Brain and Disease VIB\u2010Leuven Leuven Belgium"},{"name":"Center for Human Genetics Universitaire Ziekenhuizen and Leuven Research Institute for Neuroscience and Disease KU\u2010Leuven Leuven Belgium"},{"name":"Institute of Neurology University College London London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.cell.2015.12.056","article-title":"The cellular phase of Alzheimer's disease","volume":"164","author":"De Strooper B.","year":"2016","journal-title":"Cell"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/0092-8674(93)90529-Y","article-title":"The C. elegans heterochronic gene lin\u20104 encodes small RNAs with antisense complementarity to lin\u201014","volume":"75","author":"Lee R. C.","year":"1993","journal-title":"Cell"},{"key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S1474-4422(11)70286-1","article-title":"Non\u2010coding RNAs with essential roles in neurodegenerative disorders","volume":"11","author":"Salta E.","year":"2012","journal-title":"Lancet Neurol"},{"key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3389\/fnins.2012.00048","article-title":"Cause or effect: misregulation of microRNA pathways in neurodegeneration","volume":"6","author":"Gascon E.","year":"2012","journal-title":"Front. Neurosci"},{"key":"e_1_2_10_6_1","doi-asserted-by":"crossref","first-page":"6891","DOI":"10.3390\/molecules19056891","article-title":"Circulating miRNAs as biomarkers for neurodegenerative disorders","volume":"19","author":"Grasso M.","year":"2014","journal-title":"Molecules"},{"key":"e_1_2_10_7_1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3233\/JAD-2008-14103","article-title":"Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways","volume":"14","author":"Cogswell J. P.","year":"2008","journal-title":"J. Alzheimers Dis"},{"key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1002\/emmm.201201974","article-title":"Alteration of the microRNA network during the progression of Alzheimer's disease","volume":"5","author":"Lau P.","year":"2013","journal-title":"EMBO Mol. Med"},{"key":"e_1_2_10_9_1","doi-asserted-by":"crossref","first-page":"335","DOI":"10.3233\/JAD-122350","article-title":"A study of small RNAs from cerebral neocortex of pathology\u2010veri~ed Alzheimer's disease, dementia with Lewy bodies, hippocampal sclerosis, frontotemporal lobar dementia, and non\u2010demented human controls","volume":"35","author":"H\u00e9bert S. S.","year":"2013","journal-title":"J. Alzheimers Dis"},{"key":"e_1_2_10_10_1","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1093\/hmg\/ddt164","article-title":"De\u2010repression of FOXO3a death axis by microRNA\u2010132 and \u2212212 causes neuronal apoptosis in Alzheimer's disease","volume":"22","author":"Wong H. K.A.","year":"2013","journal-title":"Hum. Mol. Genet"},{"key":"e_1_2_10_11_1","doi-asserted-by":"crossref","first-page":"6721","DOI":"10.1093\/hmg\/ddv377","article-title":"miR\u2010132\/212 deficiency impairs tau metabolism and promotes pathological aggregation in vivo","volume":"24","author":"Smith P. Y.","year":"2015","journal-title":"Hum. Mol. Genet"},{"key":"e_1_2_10_12_1","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1093\/brain\/awv383","article-title":"microRNA\u2010132 and early growth response\u20101 in nucleus basalis of Meynert during the course of Alzheimer's disease","volume":"139","author":"Zhu Q. B.","year":"2016","journal-title":"Brain"},{"key":"e_1_2_10_13_1","article-title":"The miRNome of Alzheimer's disease: consistent downregulation of the miR\u2010132\/212 cluster","author":"Pichler S.","year":"2016","journal-title":"Neurobiol. Aging"},{"key":"e_1_2_10_14_1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.arr.2014.02.006","article-title":"Variance in the identification of microRNAs deregulated in Alzheimer's disease and possible role of lincRNAs in the pathology: the need of larger datasets","volume":"17","author":"Lau P.","year":"2014","journal-title":"Ageing Res. Rev"},{"key":"e_1_2_10_15_1","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1002\/prca.200780025","article-title":"microRNA and proteome expression profiling in early\u2010symptomatic a\u2010synuclein (A30P)\u2010transgenic mice","volume":"2","author":"Gillardon F.","year":"2008","journal-title":"Proteomics Clin. Appl"},{"key":"e_1_2_10_16_1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s12017-009-8063-4","article-title":"Gene dysregulation in Huntington's disease: REST, microRNAs and beyond","volume":"11","author":"Johnson R.","year":"2009","journal-title":"Neuromolecular Med"},{"key":"e_1_2_10_17_1","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/2051-5960-1-42","article-title":"Systemic dysregulation of TDP\u201043 binding microRNAs in amyotrophic lateral sclerosis","volume":"1","author":"Freischmidt A.","year":"2013","journal-title":"Acta Neuropathol. Commun"},{"key":"e_1_2_10_18_1","article-title":"TMEM106B, the risk gene for frontotemporal dementia, is regulated by the microRNA\u2010132\/212 cluster and affects progranulin pathways","volume":"32","author":"Chen\u2010Plotkin A. S.","year":"2012","journal-title":"J. Neurosci"},{"key":"e_1_2_10_19_1","doi-asserted-by":"crossref","first-page":"e1003002","DOI":"10.1371\/journal.ppat.1003002","article-title":"Early mechanisms of pathobiology are revealed by transcriptional temporal dynamics in hippocampal CA1 neurons of prion infected mice","volume":"8","author":"Majer A.","year":"2012","journal-title":"PLoS Pathog"},{"key":"e_1_2_10_20_1","doi-asserted-by":"crossref","first-page":"4742","DOI":"10.1093\/nar\/gks151","article-title":"miR\u2010212\/ 132 expression and functions: within and beyond the neuronal compartment","volume":"40","author":"Wanet A.","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"e_1_2_10_21_1","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1015691107","article-title":"microRNA\u2010132 regulates dendritic growth and arborization of newborn neurons in the adult hippocampus","volume":"107","author":"Magill S. T.","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_2_10_22_1","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/nn.3599","article-title":"Identification of a unique TGF\u2010\u03b2\u2010dependent molecular and functional signature in microglia","volume":"17","author":"Butovsky O.","year":"2014","journal-title":"Nat. Neurosci"},{"key":"e_1_2_10_23_1","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.immuni.2015.04.022","article-title":"A single miRNA\u2010mRNA interaction affects the immune response in a context\u2010and cell\u2010type\u2010specific manner","volume":"43","author":"Lu L.\u2010F.","year":"2015","journal-title":"Immunity"},{"key":"e_1_2_10_24_1","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.molcel.2014.09.018","article-title":"Endogenous miRNA and target concentrations determine susceptibility to potential ceRNA competition","volume":"56","author":"Bosson A. D.","year":"2014","journal-title":"Mol. Cell"},{"key":"e_1_2_10_25_1","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1002\/hipo.20646","article-title":"Neuronal activity rapidly induces transcription of the CRE\u03b2\u2010regulated microRNA\u2010132, in vivo","volume":"20","author":"Nudelman A. S.","year":"2010","journal-title":"Hippocampus"},{"key":"e_1_2_10_26_1","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1007\/s00429-012-0431-4","article-title":"miRNA\u2010132: a dynamic regulator of cognitive capacity","volume":"218","author":"Hansen K. F.","year":"2013","journal-title":"Brain Struct. Funct"},{"key":"e_1_2_10_27_1","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1038\/nn.2909","article-title":"miR\u2010132, an experience\u2010dependent microRNA, is essential for visual cortex plasticity","volume":"14","author":"Mellios N.","year":"2011","journal-title":"Nat. Neurosci"},{"key":"e_1_2_10_28_1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.biocel.2011.10.015","article-title":"microRNA212\/132 family: molecular transducer of neuronal function and plasticity","volume":"44","author":"Tognini P.","year":"2012","journal-title":"Int. J. Biochem. Cell Biol"},{"key":"e_1_2_10_29_1","doi-asserted-by":"crossref","first-page":"9093","DOI":"10.1073\/pnas.0803072105","article-title":"An activity\u2010regulated microRNA controls dendritic plasticity by down\u2010regulating p250GAP","volume":"105","author":"Wayman G. A.","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_2_10_30_1","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1093\/hmg\/ddq519","article-title":"miRNA\u2010132 orchestrates chromatin remodeling and translational control of the circadian clock","volume":"20","author":"Alvarez\u2010Saavedra M.","year":"2011","journal-title":"Hum. Mol. Genet"},{"key":"e_1_2_10_31_1","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.neuron.2007.05.017","article-title":"microRNA modulation of circadian\u2010clock period and entrainment","volume":"54","author":"Cheng H. Y. M.","year":"2007","journal-title":"Neuron"},{"key":"e_1_2_10_32_1","article-title":"A cAMP\u2010response element binding protein\u2010induced microRNA regulates neuronal morphogenesis","volume":"102","author":"Vo N.","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_2_10_33_1","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1038\/nn2010","article-title":"Homeostatic regulation of MeCP2 expression by a CRE\u03b2\u2010induced microRNA","volume":"10","author":"Klein M. E.","year":"2007","journal-title":"Nat. Neurosci"},{"key":"e_1_2_10_34_1","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0896-6273(00)81011-9","article-title":"Identification of a signaling pathway involved in calcium regulation of BDNF expression","volume":"20","author":"Shieh P. B.","year":"1998","journal-title":"Neuron"},{"key":"e_1_2_10_35_1","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0896-6273(00)81010-7","article-title":"Ca2+ in~ux regulates BDNF transcription by a CREB family transcription factor\u2010dependent mechanism","volume":"20","author":"Tao X.","year":"1998","journal-title":"Neuron"},{"key":"e_1_2_10_36_1","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1523\/JNEUROSCI.20-08-02809.2000","article-title":"Brain\u2010derived neurotrophic factor causes cAMP response element\u2010binding protein phosphorylation in absence of calcium increases in slices and cultured neurons from rat visual cortex","volume":"20","author":"Pizzorusso T.","year":"2000","journal-title":"J. Neurosci"},{"key":"e_1_2_10_37_1","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1042\/BJ20100024","article-title":"Regulation of the miR\u2010212\/132 locus by MSK1 and CREB in response to neurotrophins","volume":"428","author":"Remenyi J.","year":"2010","journal-title":"Biochem. J"},{"key":"e_1_2_10_38_1","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/j.neuroscience.2009.11.057","article-title":"Glucocorticoid attenuates brain\u2010derived neurotrophic factor\u2010dependent upregulation of glutamate receptors via the suppression of microRNA\u2010132 expression","volume":"165","author":"Kawashima H.","year":"2010","journal-title":"Neuroscience"},{"key":"e_1_2_10_39_1","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1111\/j.1471-4159.2005.03135.x","article-title":"Precursor form of brain\u2010derived neurotrophic factor and mature brain\u2010derived neurotrophic factor are decreased in the pre\u2010clinical stages of Alzheimer's disease","volume":"93","author":"Peng S.","year":"2005","journal-title":"J. Neurochem"},{"key":"e_1_2_10_40_1","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/S0006-8993(99)01220-2","article-title":"Impaired phosphorylation of cyclic AMP response element binding protein in the hippocampus of dementia of the Alzheimer type","volume":"824","author":"Yamamoto\u2010Sasaki M.","year":"1999","journal-title":"Brain Res"},{"key":"e_1_2_10_41_1","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1016\/j.neurobiolaging.2015.04.014","article-title":"CREB expression mediates amyloid \u03b2\u2010induced basal BDNF downregulation","volume":"36","author":"Rosa E.","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"e_1_2_10_42_1","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1093\/hmg\/ddv482","article-title":"Early\u2010onset sleep defects in Drosophila models of Huntington's disease reflect alterations of PKA\/CREB signaling","volume":"25","author":"Gonzales E. D.","year":"2016","journal-title":"Hum. Mol. Genet"},{"key":"e_1_2_10_43_1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1093\/hmg\/ddr492","article-title":"CRE\u03b2\u2010activity and nmnat2 transcription are down\u2010regulated prior to neurodegeneration, while NMNAT2 over\u2010expression is neuroprotective, in a mouse model of human tauopathy","volume":"21","author":"Ljungberg M. C.","year":"2012","journal-title":"Hum. Mol. Genet"},{"key":"e_1_2_10_44_1","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.conb.2005.08.015","article-title":"The many faces of REST oversee epigenetic programming of neuronal genes","volume":"15","author":"Ballas N.","year":"2005","journal-title":"Curr. Opin. Neurobiol"},{"key":"e_1_2_10_45_1","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/nature13163","article-title":"REST and stress resistance in ageing and Alzheimer's disease","volume":"507","author":"Lu T.","year":"2014","journal-title":"Nature"},{"key":"e_1_2_10_46_1","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.devcel.2014.07.006","article-title":"A self\u2010organizing miR\u2010132\/Ctbp2 circuit regulates bimodal Notch signals and glial progenitor fate choice during spinal cord maturation","volume":"30","author":"Salta E.","year":"2014","journal-title":"Dev. Cell"},{"key":"e_1_2_10_47_1","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1073\/pnas.0511041103","article-title":"Reciprocal actions of REST and a microRNA promote neuronal identity","volume":"103","author":"Conaco C.","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_2_10_48_1","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S0092-8674(04)00248-X","article-title":"A small modulatory dsRNA speci~es the fate of adult neural stem cells","volume":"116","author":"Kuwabara T.","year":"2004","journal-title":"Cell"},{"key":"e_1_2_10_49_1","doi-asserted-by":"crossref","first-page":"3454","DOI":"10.1016\/j.jmb.2014.07.032","article-title":"The gene silencing transcription factor REST represses miR132 expression in hippocampal neurons destined to die","volume":"426","author":"Hwang J.\u2010Y.","year":"2014","journal-title":"J. Mol. Biol"},{"key":"e_1_2_10_50_1","doi-asserted-by":"crossref","first-page":"e62509","DOI":"10.1371\/journal.pone.0062509","article-title":"miR\u2010132\/212 knockout mice reveal roles for these miRNAs in regulating cortical synaptic transmission and plasticity","volume":"8","author":"Remenyi J.","year":"2013","journal-title":"PLoS One"},{"key":"e_1_2_10_51_1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.brainresbull.2013.12.004","article-title":"The dendritic hypothesis for Alzheimer's disease pathophysiology","volume":"103","author":"Cochran J. N.","year":"2014","journal-title":"Brain Res. Bull"},{"key":"e_1_2_10_52_1","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.neuron.2009.05.012","article-title":"Soluble oligomers of amyloid beta protein facilitate hippocampal long\u2010term depression by disrupting neuronal glutamate uptake","volume":"62","author":"Li S.","year":"2009","journal-title":"Neuron"},{"key":"e_1_2_10_53_1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s00401-013-1215-5","article-title":"Soluble pathological tau in the entorhinal cortex leads to presynaptic deficits in an early Alzheimer's disease model","volume":"127","author":"Polydoro M.","year":"2014","journal-title":"Acta Neuropathol"},{"key":"e_1_2_10_54_1","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1016\/j.neurobiolaging.2013.11.031","article-title":"Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain","volume":"35","author":"Coppieters N.","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"e_1_2_10_55_1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/onc.2012.14","article-title":"DNA methylation silences miR\u2010132 in prostate cancer","volume":"32","author":"Formosa A.","year":"2013","journal-title":"Oncogene"},{"key":"e_1_2_10_56_1","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1093\/carcin\/bgr105","article-title":"Downregulation of miR\u2010132 by promoter methylation contributes to pancreatic cancer development","volume":"32","author":"Zhang S.","year":"2011","journal-title":"Carcinogenesis"},{"key":"e_1_2_10_57_1","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.15252\/emmm.201606520","article-title":"miR\u2010132 loss de\u2010represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain","volume":"8","author":"Salta E.","year":"2016","journal-title":"EMBO Mol. Med"},{"key":"e_1_2_10_58_1","doi-asserted-by":"crossref","DOI":"10.1038\/srep30953","article-title":"microRNA\u2010132\/212 deficiency enhances Ab production and senile plaque deposition in Alzheimer's disease triple transgenic mice","volume":"6","author":"Hernandez\u2010Rapp J.","year":"2016","journal-title":"Sci. Rep"},{"key":"e_1_2_10_59_1","first-page":"355","article-title":"Tau domains, phosphorylation, and interactions with microtubules","author":"Mandelkow E. M.","year":"1995","journal-title":"Neurobiol"},{"key":"e_1_2_10_60_1","doi-asserted-by":"crossref","first-page":"4016","DOI":"10.1093\/hmg\/ddr330","article-title":"microRNA\u2010132lossisassociated with tau exon 10 inclusion in progressive supranuclear palsy","volume":"20","author":"Smith P. Y.","year":"2011","journal-title":"Hum. Mol. Genet"},{"key":"e_1_2_10_61_1","doi-asserted-by":"crossref","first-page":"e19077","DOI":"10.1371\/journal.pone.0019077","article-title":"miR\u2010132 mediates the integration of newborn neurons into the adult dentate gyrus","volume":"6","author":"Luikart B. W.","year":"2011","journal-title":"PLoS One"},{"key":"e_1_2_10_62_1","first-page":"1673","article-title":"miR\u2010132 regulates the differentiation of dopamine neurons by directly targeting Nurr1 expression","volume":"125","author":"Yang D.","year":"2012","journal-title":"J. Cell Sci"},{"key":"e_1_2_10_63_1","doi-asserted-by":"crossref","first-page":"3332","DOI":"10.1242\/dev.078063","article-title":"Convergent repression of Foxp2 3\u2019UTR by miR\u20109 and miR\u2010132 in embryonic mouse neocortex: implications for radial migration of neurons","volume":"139","author":"Clovis Y. M.","year":"2012","journal-title":"Development"},{"key":"e_1_2_10_64_1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/1750-1326-6-85","article-title":"Adult hippocampal neurogenesis and its role in Alzheimer's disease","volume":"6","author":"Mu Y.","year":"2011","journal-title":"Mol. Neurodegener"},{"key":"e_1_2_10_65_1","doi-asserted-by":"crossref","first-page":"e38174","DOI":"10.1371\/journal.pone.0038174","article-title":"miR\u2010132 enhances dendritic morphogenesis, spine density, synaptic integration, and survival of newborn olfactory bulb neurons","volume":"7","author":"Pathania M.","year":"2012","journal-title":"PLoS One"},{"key":"e_1_2_10_66_1","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1523\/JNEUROSCI.3371-13.2014","article-title":"microRNA\u2010132 is enriched in developing axons, locally regulates Rasa1 mRNA, and promotes axon extension","volume":"34","author":"Hancock M. L.","year":"2014","journal-title":"J. Neurosci"},{"key":"e_1_2_10_67_1","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.neuron.2010.01.005","article-title":"Regulation of synaptic structure and function by FMRP\u2010associated microRNAs miR\u2010125b and miR\u2010132","volume":"65","author":"Edbauer D.","year":"2010","journal-title":"Neuron"},{"key":"e_1_2_10_68_1","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.mcn.2009.10.005","article-title":"An activity\u2010induced microRNA controls dendritic spine formation by regulating Rac1\u2010PAK signaling","volume":"43","author":"Impey S.","year":"2010","journal-title":"Mol. Cell. Neurosci"},{"key":"e_1_2_10_69_1","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.neuron.2014.05.004","article-title":"The intersection of amyloid beta and tau at synapses in Alzheimer's disease","volume":"82","author":"Spires\u2010Jones T. L.","year":"2014","journal-title":"Neuron"},{"key":"e_1_2_10_70_1","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1002\/hipo.22123","article-title":"vivo knockdown of hippocampal miR\u2010132 expression impairs memory acquisition of trace fear conditioning","volume":"23","author":"Wang R. Y.","year":"2013","journal-title":"Hippocampus"},{"key":"e_1_2_10_71_1","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1111\/j.1460-9568.2012.08220.x","article-title":"microRNA\u2010132 regulates recognition memory and synaptic plasticity in the perirhinal cortex","volume":"36","author":"Scott H. L.","year":"2012","journal-title":"Eur. J. Neurosci"},{"key":"e_1_2_10_72_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.bbr.2015.03.032","article-title":"Memory formation and retention are affected in adult miR\u2010132\/212 knockout mice","volume":"287","author":"Hernandez\u2010Rapp J.","year":"2015","journal-title":"Behav. Brain Res"},{"key":"e_1_2_10_73_1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3389\/fgene.2014.00088","article-title":"Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models","volume":"5","author":"Webster S. J.","year":"2014","journal-title":"Front. Genet"},{"key":"e_1_2_10_74_1","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S1474-4422(15)70016-5","article-title":"Neuroinflammation in Alzheimer's disease","volume":"14","author":"Heneka M. T.","year":"2015","journal-title":"Lancet Neurol"},{"key":"e_1_2_10_75_1","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.4067-11.2011","article-title":"Neuron\u2010specific effects of interleukin\u20101b are mediated by a novel isoform of the IL\u20101 receptor accessory protein","volume":"31","author":"Huang Y.","year":"2011","journal-title":"J. Neurosci"},{"key":"e_1_2_10_76_1","article-title":"Tumor necrosis factor alpha: a link between neuroinflammation and excitotoxicity","volume":"2014","author":"Olmos G.","year":"2014","journal-title":"Mediators In~amm"},{"key":"e_1_2_10_77_1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.tins.2011.02.005","article-title":"Toll\u2010like receptor signaling in neural plasticity and disease","volume":"34","author":"Okun E.","year":"2011","journal-title":"Trends Neurosci"},{"key":"e_1_2_10_78_1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M112.387670","article-title":"In~uenza A virus infection of human respiratory cells induces primary microRNA expression","volume":"287","author":"Buggele W. A.","year":"2012","journal-title":"J. Biol. Chem"},{"key":"e_1_2_10_79_1","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/ncb2054","article-title":"miR\u2010132 regulates antiviral innate immunity through suppression of the p300 transcriptional coactivator","volume":"12","author":"Lagos D.","year":"2010","journal-title":"Nat. Cell Biol"},{"key":"e_1_2_10_80_1","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.4049\/jimmunol.1103060","article-title":"Regulation of TLR2\u2010mediated tolerance and cross\u2010tolerance through IRAK4 modulation by miR\u2010132 and miR","volume":"190","author":"Nahid M. A.","year":"2013","journal-title":"J. Immunol"},{"key":"e_1_2_10_81_1","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.0605298103","article-title":"NF\u2010kappa\u03b2\u2010dependent induction of microRNA miR\u2010146, an inhibitor targeted to signaling proteins of innate immune responses","volume":"103","author":"Taganov K. D.","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_2_10_82_1","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.neuroscience.2014.03.015","article-title":"microRNA132 dysregulation in Toxoplasma gondii infection has implications for dopamine signaling pathway","volume":"268","author":"Xiao J.","year":"2014","journal-title":"Neuroscience"},{"key":"e_1_2_10_83_1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s00436-013-3630-x","article-title":"Dynamic expression of miR\u2010132, miR\u2010212, and miR\u2010146 in the brain of different hosts infected with Angiostrongylus cantonensis","volume":"113","author":"Yu L.","year":"2014","journal-title":"Parasitol. Res"},{"key":"e_1_2_10_84_1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s12031-015-0574-x","article-title":"The effect of miR\u2010132, miR\u2010146a, and miR\u2010155 on MRP8\/TLR4induced astrocyte\u2010related inflammation","volume":"57","author":"Kong H.","year":"2015","journal-title":"J. Mol. Neurosci"},{"key":"e_1_2_10_85_1","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.immuni.2009.09.019","article-title":"microRNA\u2010132 potentiates cholinergic anti\u2010inflammatory signaling by targeting acetylcholinesterase","volume":"31","author":"Shaked I.","year":"2009","journal-title":"Immunity"},{"key":"e_1_2_10_86_1","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/35013070","article-title":"Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin","volume":"405","author":"Borovikova L. V.","year":"2000","journal-title":"Nature"},{"key":"e_1_2_10_87_1","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/nrn3880","article-title":"Immune attack: the role of inflammation in Alzheimer disease","volume":"16","author":"Heppner F. L.","year":"2015","journal-title":"Nat. Rev. Neurosci"},{"key":"e_1_2_10_88_1","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1038\/nm.2186","article-title":"microRNA132\u2010mediated loss of p120RasGAP activates the endothelium to facilitate pathological angiogenesis","volume":"16","author":"Anand S.","year":"2010","journal-title":"Nat. Med"},{"key":"e_1_2_10_89_1","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1111\/j.1460-9568.2012.08126.x","article-title":"The early contribution of cerebrovascular factors to the pathogenesis of Alzheimer's disease","volume":"35","author":"Pimentel\u2010Coelho P. M.","year":"2012","journal-title":"Eur. J. Neurosci"},{"key":"e_1_2_10_90_1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.2174\/1567205010666131120100743","article-title":"Dysregulation of neurotrophic and haematopoietic growth factors in Alzheimer's disease: from pathophysiology to novel treatment strategies","volume":"11","author":"Sopova K.","year":"2014","journal-title":"Curr. Alzheimer Res"},{"key":"e_1_2_10_91_1","doi-asserted-by":"crossref","first-page":"6233","DOI":"10.1111\/febs.12546","article-title":"miRNA expression is modulated over time after focal ischaemia: up\u2010regulation of miR\u2010347 promotes neuronal apoptosis","volume":"280","author":"Gubern C.","year":"2013","journal-title":"FEBS J"},{"key":"e_1_2_10_92_1","doi-asserted-by":"crossref","first-page":"367","DOI":"10.3727\/096368915X686869","article-title":"Time\u2010dependent profiles of microRNA expression induced by ischemic preconditioning in the gerbil hippocampus","volume":"24","author":"Sun M.","year":"2015","journal-title":"Cell Transplant"},{"key":"e_1_2_10_93_1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3389\/fnins.2016.00059","article-title":"Anti\u2010microRNAs as novel therapeutic agents in the clinical management of Alzheimer's disease","volume":"10","author":"Zhao Y.","year":"2016","journal-title":"Front. Neurosci"},{"key":"e_1_2_10_94_1","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1161\/CIRCRESAHA.111.247916","article-title":"Developing microRNA therapeutics","volume":"110","author":"Van Rooij E.","year":"2012","journal-title":"Circ. Res"},{"key":"e_1_2_10_95_1","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1517\/17425247.2015.1065812","article-title":"Intranasal delivery: circumventing the iron curtain to treat neurological disorders","volume":"12","author":"Jiang Y.","year":"2015","journal-title":"Expert Opin. DrugDeliv"},{"key":"e_1_2_10_96_1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/ana.23588","article-title":"miR\u2010206 regulates brain\u2010derived neurotrophic factor in Alzheimer disease model","volume":"72","author":"Lee S\u2010T.","year":"2012","journal-title":"Ann. Neurol"},{"issue":"2","key":"e_1_2_10_97_1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/jnc.13632","article-title":"The amyloid cascade hypothesis: are we poised for success or failure","volume":"139","author":"Karran E.","year":"2016","journal-title":"J. Neurochem"},{"key":"e_1_2_10_98_1","doi-asserted-by":"crossref","first-page":"e331","DOI":"10.1038\/mtna.2016.47","article-title":"Altered Levels of microRNA\u20109, \u2212206, and \u2212132 in spinal muscular atrophy and their response to antisense oligonucleotide therapy","volume":"5","author":"Catapano F.","year":"2016","journal-title":"Mol. Ther. Nucleic Acids"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.201601308","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1096\/fj.201601308","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.201601308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T21:09:55Z","timestamp":1761685795000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.201601308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,13]]},"references-count":97,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1096\/fj.201601308"],"URL":"https:\/\/doi.org\/10.1096\/fj.201601308","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,13]]},"assertion":[{"value":"2016-12-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-12-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-01-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}