{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T15:29:43Z","timestamp":1793460583614,"version":"4.5.0"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,3,7]],"date-time":"2017-03-07T00:00:00Z","timestamp":1488844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The physiologic properties of glucagon\u2010like peptide 1 (GLP\u20101) make it a potent candidate drug target in the treatment of type 2 diabetes mellitus (T2DM). GLP\u20101 is capable of regulating the blood glucose level by insulin secretion after administration of oral glucose. The advantages of GLP\u20101 for the avoidance of hypoglycemia and the control of body weight are attractive despite its poor stability. The clinical efficacies of long\u2010acting GLP\u20101 derivatives strongly support discovery pursuits aimed at identifying and developing orally active, small\u2010molecule GLP\u20101 receptor (GLP\u20101R) agonists. The purpose of this study was to identify and characterize a novel oral agonist of GLP\u20101R (\n                    <jats:italic>i.e.<\/jats:italic>\n                    , myricetin). The insulinotropic characterization of myricetin was performed in isolated islets and in Wistar rats. Long\u2010term oral administration of myricetin demonstrated glucoregulatory activity. The data in this study suggest that myricetin might be a potential drug candidate for the treatment of T2DM as a GLP\u20101R agonist. Further structural modifications on myricetin might improve its pharmacology and pharmacokinetics.\u2014Li, Y., Zheng, X., Yi, X., Liu, C., Kong, D., Zhang, J., Gong, M. Myricetin: a potent approach for the treatment of type 2 diabetes as a natural class B GPCR agonist. FASEB J. 31, 2603\u20132611 (2017).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201601339r","type":"journal-article","created":{"date-parts":[[2017,3,7]],"date-time":"2017-03-07T21:10:40Z","timestamp":1488921040000},"page":"2603-2611","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["Myricetin: a potent approach for the treatment of type 2 diabetes as a natural class B GPCR agonist"],"prefix":"10.1096","volume":"31","author":[{"given":"Ying","family":"Li","sequence":"first","affiliation":[{"name":"Tianjin Neurological Institute Tianjin Medical University General Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemin","family":"Zheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Drug Delivery Technology and Pharmacokinetics Tianjin Institute of Pharmaceutical Research  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiulin","family":"Yi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Drug Delivery Technology and Pharmacokinetics Tianjin Institute of Pharmaceutical Research  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changxiao","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Drug Delivery Technology and Pharmacokinetics Tianjin Institute of Pharmaceutical Research  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dexin","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianning","family":"Zhang","sequence":"additional","affiliation":[{"name":"Tianjin Neurological Institute Tianjin Medical University General Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Tianjin Medical University  Tianjin China"},{"name":"Department of Oncology University of Oxford  Oxford United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2013.11.004"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2012.11.006"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2013.02.006"},{"key":"e_1_2_8_5_1","doi-asserted-by":"crossref","DOI":"10.5888\/pcd11.130300","article-title":"Diabetes interactive atlas","volume":"11","author":"Kirtland K. 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