{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:26:29Z","timestamp":1792009589011,"version":"4.4.0"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,9,19]],"date-time":"2017-09-19T00:00:00Z","timestamp":1505779200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In renal failure, hyperphosphatemia occurs despite a marked elevation in serum fibroblast growth factor (FGF)\u201023. Abnormal regulation of the FGFR1\u2010Klotho receptor complex may cause a resistance to the phosphaturic action of FGF23. The purpose of the present study was to investigate the regulation of renal Klotho and FGF receptor (FEFR)\u20101 in healthy and uremic rats induced by 5\/6 nephrectomy. In normal rats, the infusion of rat recombinant FGF23 enhanced phosphaturia and increased renal FGFR1 expression; however, Klotho expression was reduced. Uremic rats on a highphosphate (HP) diet presented hyperphosphatemia with marked elevation of FGF23 and an increased fractional excretion of phosphate (P) that was associated with a marked reduction of Klotho expression and an increase in FGFR1. After neutralization of FGF23 by anti\u2010FGF23 administration, phosphaturia was still abundant, Klotho expression remained low, and the FGFR1 level was reduced. These results suggest that the expression of renal Klotho is modulated by phosphaturia, whereas the FGFR1 expression is regulated by FGF23. Calcitriol (CTR) administration prevented a decrease in renal Klotho expression. In HEK293 cells HP produced nuclear translocation of \u03b2\u2010cateniv together with a reduction in Klotho. Wnt\/\u03b2\u2010catenin inhibition with Dkk\u20101 prevented the P\u2010induced down\u2010regulation of Klotho. The addition of CTR to HP medium was able to recover Klotho expression. In summary, high FGF23 levels increase FGFR1, whereas phosphaturia decreases Klotho expression through the activation of Wnt\/\u03b2\u2010catenin pathway.\u2014Mu\u00f1oz\u2010Casta\u00f1eda, J. R., Herencia, C., Pend\u00f3n\u2010Ruiz de Mier M. V., Rodriguez\u2010Ortiz, M. E., Diaz\u2010Tocados, J. M., Vergara, N., Mart\u00ednez\u2010Moreno, J. M., Salmer\u00f3n M. D., Richards, W. G., Felsenfeld, A., Kuro\u2010O, M., Almad\u00e9n Y., Rodr\u00edguez, M. Differential regulation of renal Klotho and FGFR1 in normal and uremic rats. FASEB J. 31, 3858\u20133867 (2017).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                    \u2014Mu\u00f1oz\u2010Casta\u00f1eda, Juan R., Herencia, Carmen, Pend\u00f3n\u2010Ruiz de Mier, Maria Victoria, Rodriguez\u2010Ortiz, Maria Encarnaci\u00f3n, Diaz\u2010Tocados, Juan M., Vergara, Noemi, Mart\u00ednez\u2010Moreno, Julio M., Salmer\u00f3n, Maria Dolores, Richards, William G., Felsenfeld, Arnold, Kuro\u2010O, Makoto, Almad\u00e9n, Yolanda, Rodr\u00edguez, Mariano Differential regulation of renal Klotho and FGFR1 in normal and uremic rats. FASEB J. 31, 3858\u20133867 (2017)\n                  <\/jats:p>","DOI":"10.1096\/fj.201700006r","type":"journal-article","created":{"date-parts":[[2017,5,17]],"date-time":"2017-05-17T21:05:19Z","timestamp":1495055119000},"page":"3858-3867","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Differential regulation of renal Klotho and FGFR1 in normal and uremic rats"],"prefix":"10.1096","volume":"31","author":[{"given":"Juan R.","family":"Mu\u00f1oz\u2010Casta\u00f1eda","sequence":"first","affiliation":[{"name":"Instituto Maim\u00f3nides para la Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba (IMIBIC)  C\u00f3rdoba Spain"},{"name":"Unidad de Gesti\u00f3n Cl\u00ednica (UGC) Nefrolog\u00eda Hospital Universitario Reina Sof\u00eda  C\u00f3rdoba Spain"},{"name":"Departamento de Medicina Universidad de C\u00f3rdoba  C\u00f3rdoba Spain"},{"name":"Red Nacional de Investigaci\u00f3n en Nefrolog\u00eda (REDinREN) Instituto 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