{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:08:02Z","timestamp":1790820482911,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,8,21]],"date-time":"2017-08-21T00:00:00Z","timestamp":1503273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008801","name":"Atlanta Clinical and Translational Science Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008801","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R21 HD086357"],"award-info":[{"award-number":["R21 HD086357"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["13SDG17390009"],"award-info":[{"award-number":["13SDG17390009"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2017,12]]},"abstract":"ABSTRACT<\/jats:title>\n \n Accurate analysis of placental and fetal oxygenation is critical during pregnancy. Photoacoustic imaging (PAI) combines laser technology with ultrasound in real time. We tested the sensitivity and accuracy of PAI for analysis of placental and fetal oxygen saturation (sO\n 2<\/jats:sub>\n ) in mice. The placental labyrinth (L) had a higher sO\n 2<\/jats:sub>\n than the junctional zone plus decidua region (JZ+D) in C57Bl\/6 mice. Changing maternal O\n 2<\/jats:sub>\n from 100 to 20% in C57Bl\/6 mice lowered sO\n 2<\/jats:sub>\n in these regions. C57Bl\/6 mice were treated with the NO synthase inhibitor L\u2010N\n G<\/jats:sup>\n \u2010nitroarginine methyl ester (L\u2010NAME) from gestational day (GD) 11 to GD18 to induce hypertension. L\u2010NAME decreased sO\n 2<\/jats:sub>\n in L and JZ+D at GD14 and GD18 in association with fetal growth restriction and higher blood pressure. Hypoxia\u2010inducible factor 1a immunostaining was higher in L\u2010NAME\n vs.<\/jats:italic>\n control mice at GD14. Fetal sO\n 2<\/jats:sub>\n levels were similar between\n l<\/jats:sc>\n \u2010NAME and control mice at GD14 and GD18. In contrast to untreated C57Bl\/6, L\u2010NAME decreased placental sO\n 2<\/jats:sub>\n at GD14 and GD18\n vs.<\/jats:italic>\n GD10 or GD12. Placental sO\n 2<\/jats:sub>\n was lower in fetal growth restriction in an angiotensin\u2010converting enzyme 2 knockout mouse model characterized by placental hypoxia. On phantom studies, patterns of sO\n 2<\/jats:sub>\n measured directly correlated with those measured by PAI. In summary, PAI enables the detection of placental and fetal oxygenation during normal and pathologic pregnancies in mice.\u2014Yamaleyeva, L. M., Sun, Y., Bledsoe, T., Hoke, A., Gurley, S. B., Brosnihan, K. B. Photoacoustic imaging for\n in vivo<\/jats:italic>\n quantification of placental oxygenation in mice. FASEB J. 31, 5520\u20135529 (2017).\n www.fasebj.org<\/jats:ext-link>\n <\/jats:p>","DOI":"10.1096\/fj.201700047rr","type":"journal-article","created":{"date-parts":[[2017,8,21]],"date-time":"2017-08-21T20:40:21Z","timestamp":1503348021000},"page":"5520-5529","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Photoacoustic imaging for\n in vivo<\/i>\n quantification of placental oxygenation in mice"],"prefix":"10.1096","volume":"31","author":[{"given":"Liliya M.","family":"Yamaleyeva","sequence":"first","affiliation":[{"name":"Department of Surgery\/Hypertension and Vascular Research Wake Forest School of Medicine Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Radiology Wake Forest School of Medicine Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffaney","family":"Bledsoe","sequence":"additional","affiliation":[{"name":"Department of Surgery\/Hypertension and Vascular Research Wake Forest School of Medicine Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asia","family":"Hoke","sequence":"additional","affiliation":[{"name":"Department of Surgery\/Hypertension and Vascular Research Wake Forest School of Medicine Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan B.","family":"Gurley","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine Durham Veterans Affairs Duke University Medical Centers Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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