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To determine whether M\u2010SOB effects in such chronic diseases as MS can be experimentally modeled, we examined the effect of M\u2010SOB on susceptibility of C57BL\/6J mice to experimental autoimmune encephalomyelitis (EAE). As in MS, mice that were born during the M\u2010SOB with the lowest birth rate were less susceptible to EAE than mice born during the M\u2010SOB with the highest birth rate. We also show that the M\u2010SOB effect on EAE susceptibility is associated with differential production of multiple cytokines\/chemokines by neuroantigen\u2010specific T cells that are known to play a role in EAE pathogenesis. Taken together, these results support the existence of an M\u2010SOB effect that may reflect seasonally dependent developmental differences in adaptive immune responses to self\u2010antigens independent of external stimuli, including exposure to sunlight and vitamin D. Moreover, our documentation of an M\u2010SOB effect on EAE susceptibility in mice allows for modeling and detailed analysis of mechanisms that underlie the M\u2010SOB effect in not only MS but in numerous other diseases in which M\u2010SOB impacts susceptibility.\u2014Reynolds, J. D., Case, L. K., Krementsov, D. N., Raza, A., Bartiss, R., Teuscher, C. Modeling month\u2010season of birth as a risk factor in mouse models of chronic disease: from multiple sclerosis to autoimmune encephalomyelitis. FASEB J. 31, 2709\u20132719 (2017).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.201700062","type":"journal-article","created":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T20:20:15Z","timestamp":1489522815000},"page":"2709-2719","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Modeling month\u2010season of birth as a risk factor in mouse models of chronic disease: from multiple sclerosis to autoimmune encephalomyelitis"],"prefix":"10.1096","volume":"31","author":[{"given":"Jacob D.","family":"Reynolds","sequence":"first","affiliation":[{"name":"Department of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laure K.","family":"Case","sequence":"additional","affiliation":[{"name":"Department of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitry N.","family":"Krementsov","sequence":"additional","affiliation":[{"name":"Department of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abbas","family":"Raza","sequence":"additional","affiliation":[{"name":"Department of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rose","family":"Bartiss","sequence":"additional","affiliation":[{"name":"Trudeau Institute  Saranac Lake New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cory","family":"Teuscher","sequence":"additional","affiliation":[{"name":"Department of Medicine"},{"name":"Department of Pathology University of Vermont  Burlington Vermont USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1983.tb02634.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.041431898"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh247"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajhb.20799"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-0891"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2010.110"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/S002193200999054X"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajhb.21184"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-10-69"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpp.12229"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23339"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.110.085944"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.105.009118"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.nmd.0000243762.63694.e6"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20864"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2010.38"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20898"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2010.01.019"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874325001105010134"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70191-0"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12954"},{"key":"e_1_2_8_23_1","first-page":"e186","article-title":"Birth month and cardiovascular disease risk association: is meaningfulness in the eye of the beholder? 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